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DOI	10.4103/jrptps.JRPTPS_88_19
	Cytotoxic, antimicrobial activities, and phytochemical investigation of three peach cultivars and acerola leaves
	El-Hawary, Seham S.; Mousa, Ola Mohamed; El-Fitiany, Rana Ahmed; El Gedaily, Rania A.
通讯作者	El-Fitiany, RA (corresponding author), Cairo Univ, Dept Pharmacognosy, Fac Pharm, Gizah, Egypt.
来源期刊	JOURNAL OF REPORTS IN PHARMACEUTICAL SCIENCES
ISSN	2322-1232
EISSN	2322-5106
出版年	2020
卷号	9 期号:2 页码:221-234
英文摘要	Background: Phytoconstituents of Prunus persica Linn. (Peach) and Malpighia glabra Linn. (Acerola) leaves were not thoroughly studied, although they are commonly incorporated in the food industry. Aim: Our aim is to explore metabolites and vitamins in three peach cultivars leaves; Desert red, Florida prince, Swelling and acerola. Material and Methods: Analysis was done using GC/MS (gas chromatography-mass spectrometry), HPLC (high-performance liquid chromatography), and spectrophotometry. Cytotoxicity was performed using MTT assay. Results: Total phenolic and flavonoid content varied from 79.54 to 121.51 mu g gallic acid equivalent/mg dry weight and 31.05 to 39.77 mu g quercetin equivalent/mg dry weight, respectively. Twenty-four flavonoids were identified; hesperidin was the major flavonoid in peach cultivars (3863.4 mg/100 g in Desert red, 2971 mg/100 g in Swelling, and 2624 mg/100g in Florida prince). Glucuronic acid (33.04%) and vitamin C (34 mg/100 g) were major in acerola. Thirty-four metabolites including supraene and sitosterol as well as 24 fatty-acid esters including linoleic and oleic acids were detected in the unsaponifiable and saponifiable matter, respectively. Antimicrobial activity against bacterial and fungal strains was screened in comparison with ampicillin and amphotericin B. All tested extracts significantly decreased cell viability against breast (MCF-7) and colon cell lines (HCT-116). M. glabra showed no significant difference from standard doxorubicin (0.1 mu g/mL) which may suggest a strong anticancer activity against colon cell line. Conclusion: This study may highlight the magnitude of the leaves of these plants as rich sources of important metabolites and vitamin C.
英文关键词	Acerola antimicrobial cytotoxicity GC MS HPLC peach
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000656789400008
WOS关键词	PHENOLIC-COMPOUNDS ; VITAMIN-C ; ANTIOXIDANT CAPACITY ; HPLC-DAD ; FRUITS ; NECTARINE ; GROWTH ; PEEL ; CAROTENOIDS ; POLYPHENOLS
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352639
作者单位	[El-Hawary, Seham S.; Mousa, Ola Mohamed; El-Fitiany, Rana Ahmed; El Gedaily, Rania A.] Cairo Univ, Dept Pharmacognosy, Fac Pharm, Gizah, Egypt; [Mousa, Ola Mohamed] Ahram Canadian Univ, Dept Pharmacognosy, Fac Pharm, 6th Of October City, Egypt
推荐引用方式 GB/T 7714	El-Hawary, Seham S.,Mousa, Ola Mohamed,El-Fitiany, Rana Ahmed,et al. Cytotoxic, antimicrobial activities, and phytochemical investigation of three peach cultivars and acerola leaves[J],2020,9(2):221-234.
APA	El-Hawary, Seham S.,Mousa, Ola Mohamed,El-Fitiany, Rana Ahmed,&El Gedaily, Rania A..(2020).Cytotoxic, antimicrobial activities, and phytochemical investigation of three peach cultivars and acerola leaves.JOURNAL OF REPORTS IN PHARMACEUTICAL SCIENCES,9(2),221-234.
MLA	El-Hawary, Seham S.,et al."Cytotoxic, antimicrobial activities, and phytochemical investigation of three peach cultivars and acerola leaves".JOURNAL OF REPORTS IN PHARMACEUTICAL SCIENCES 9.2(2020):221-234.