干旱区生态环境知识资源中心(Arid): Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies

Arid

DOI	10.1038/s41380-021-01161-7
	Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies
	Solmi, Marco; Radua, Joaquim; Olivola, Miriam; Croce, Enrico; Soardo, Livia; Salazar de Pablo, Gonzalo; Il Shin, Jae; Kirkbride, James B.; Jones, Peter; Kim, Jae Han; Kim, Jong Yeob; Carvalho, Andre F.; Seeman, Mary V.; Correll, Christoph U.; Fusar-Poli, Paolo
通讯作者	Fusar-Poli, P (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England. ; Fusar-Poli, P (corresponding author), Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy. ; Fusar-Poli, P (corresponding author), South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England. ; Fusar-Poli, P (corresponding author), Natl Inst Hlth Res, Maudsley Biomed Res Ctr, London, England.
来源期刊	MOLECULAR PSYCHIATRY
ISSN	1359-4184
EISSN	1476-5578
出版年	2021-06
英文摘要	Promotion of good mental health, prevention, and early intervention before/at the onset of mental disorders improve outcomes. However, the range and peak ages at onset for mental disorders are not fully established. To provide robust, global epidemiological estimates of age at onset for mental disorders, we conducted a PRISMA/MOOSE-compliant systematic review with meta-analysis of birth cohort/cross-sectional/cohort studies, representative of the general population, reporting age at onset for any ICD/DSM-mental disorders, identified in PubMed/Web of Science (up to 16/05/2020) (PROSPERO:CRD42019143015). Co-primary outcomes were the proportion of individuals with onset of mental disorders before age 14, 18, 25, and peak age at onset, for any mental disorder and across International Classification of Diseases 11 diagnostic blocks. Median age at onset of specific disorders was additionally investigated. Across 192 studies (n = 708,561) included, the proportion of individuals with onset of any mental disorders before the ages of 14, 18, 25 were 34.6%, 48.4%, 62.5%, and peak age was 14.5 years (k = 14, median = 18, interquartile range (IQR) = 11-34). For diagnostic blocks, the proportion of individuals with onset of disorder before the age of 14, 18, 25 and peak age were as follows: neurodevelopmental disorders: 61.5%, 83.2%, 95.8%, 5.5 years (k = 21, median=12, IQR = 7-16), anxiety/fear-related disorders: 38.1%, 51.8%, 73.3%, 5.5 years (k = 73, median = 17, IQR = 9-25), obsessive-compulsive/related disorders: 24.6%, 45.1%, 64.0%, 14.5 years (k = 20, median = 19, IQR = 14-29), feeding/eating disorders/problems: 15.8%, 48.1%, 82.4%, 15.5 years (k = 11, median = 18, IQR = 15-23), conditions specifically associated with stress disorders: 16.9%, 27.6%, 43.1%, 15.5 years (k = 16, median = 30, IQR = 17-48), substance use disorders/addictive behaviours: 2.9%, 15.2%, 48.8%, 19.5 years (k = 58, median = 25, IQR = 20-41), schizophrenia-spectrum disorders/primary psychotic states: 3%, 12.3%, 47.8%, 20.5 years (k = 36, median = 25, IQR = 20-34), personality disorders/related traits: 1.9%, 9.6%, 47.7%, 20.5 years (k = 6, median = 25, IQR = 20-33), and mood disorders: 2.5%, 11.5%, 34.5%, 20.5 years (k = 79, median = 31, IQR = 21-46). No significant difference emerged by sex, or definition of age of onset. Median age at onset for specific mental disorders mapped on a time continuum, from phobias/separation anxiety/autism spectrum disorder/attention deficit hyperactivity disorder/social anxiety (8-13 years) to anorexia nervosa/bulimia nervosa/obsessive-compulsive/binge eating/cannabis use disorders (17-22 years), followed by schizophrenia, personality, panic and alcohol use disorders (25-27 years), and finally post-traumatic/depressive/generalized anxiety/bipolar/acute and transient psychotic disorders (30-35 years), with overlap among groups and no significant clustering. These results inform the timing of good mental health promotion/preventive/early intervention, updating the current mental health system structured around a child/adult service schism at age 18.
类型	Review ; Early Access
语种	英语
开放获取类型	Green Published, hybrid
收录类别	SCI-E
WOS记录号	WOS:000657201100001
WOS关键词	SOUTH-LONDON OASIS ; YOUNG-PEOPLE ; RISK-FACTORS ; PSYCHOSIS ; SCHIZOPHRENIA ; HEALTH ; PSYCHIATRY ; DEPRESSION ; MORTALITY ; OUTREACH
WOS类目	Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352401
作者单位	[Solmi, Marco] Univ Padua, Neurosci Dept, Padua, Italy; [Solmi, Marco] Univ Padua, Neurosci Ctr, Padua, Italy; [Solmi, Marco; Radua, Joaquim; Olivola, Miriam; Salazar de Pablo, Gonzalo; Fusar-Poli, Paolo] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England; [Radua, Joaquim] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Mental Hlth Res Networking Ctr CIBERSAM, Imaging Mood & Anxiety Related Disorders IMARD G, Barcelona, Spain; [Radua, Joaquim] Karolinska Inst, Ctr Psychiat Res & Educ, Dept Clin Neurosci, Solna, Sweden; [Croce, Enrico] Univ Ferrara, Inst Psychiat, Dept Biomed & Specialty Surg Sci, Ferrara, Italy; [Soardo, Livia; Fusar-Poli, Paolo] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy; [Salazar de Pablo, Gonzalo] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, London, England; [Salazar de Pablo, Gonzalo] Univ Complutense, Inst Invest Sanitaria Gregorio Maranon IiSGM, ...
推荐引用方式 GB/T 7714	Solmi, Marco,Radua, Joaquim,Olivola, Miriam,et al. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies[J]. University of London,2021.
APA	Solmi, Marco.,Radua, Joaquim.,Olivola, Miriam.,Croce, Enrico.,Soardo, Livia.,...&Fusar-Poli, Paolo.(2021).Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies.MOLECULAR PSYCHIATRY.
MLA	Solmi, Marco,et al."Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies".MOLECULAR PSYCHIATRY (2021).