干旱区生态环境知识资源中心(Arid): Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment

Arid

DOI	10.1111/imr.12982
	Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment
	Desbois, Melanie; Wang, Yulei
通讯作者	Wang, YL (corresponding author), Genentech Inc, Dept Oncol Biomarker Dev, San Francisco, CA 94080 USA.
来源期刊	IMMUNOLOGICAL REVIEWS
ISSN	0105-2896
EISSN	1600-065X
出版年	2021
英文摘要	Cancer immunotherapies have rapidly changed the therapeutic landscape for cancer. Nevertheless, most of the patients show innate or acquired resistance to these therapies. Studies conducted in recent years have highlighted an emerging role of cancer-associated fibroblasts (CAFs) in immune regulation that shapes the tumor immune microenvironment (TIME) and influences response to cancer immunotherapies. In this review, we outline recent advances in the understanding of phenotypic and functional heterogeneity of CAFs. We will focus on emerging roles of CAFs in shaping the TIME, especially under a framework of tumor immunity continuum, and discuss current and future CAF-targeting therapeutic strategies in particular in the context of optimizing the success of immunotherapies.
英文关键词	cancer-associated fibroblast immune-excluded immune-desert immune-infiltrated TGF beta tumor-immune phenotype
类型	Review ; Early Access
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000656709000001
WOS关键词	MATRIX-METALLOPROTEINASE INHIBITORS ; CARCINOMA-ASSOCIATED FIBROBLASTS ; MHC CLASS-I ; T-CELLS ; ACTIVATION PROTEIN ; ANTITUMOR IMMUNITY ; STROMAL CELLS ; BREAST-CANCER ; PHASE-II ; EXTRACELLULAR-MATRIX
WOS类目	Immunology
WOS研究方向	Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352233
作者单位	[Desbois, Melanie; Wang, Yulei] Genentech Inc, Dept Oncol Biomarker Dev, San Francisco, CA 94080 USA
推荐引用方式 GB/T 7714	Desbois, Melanie,Wang, Yulei. Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment[J],2021.
APA	Desbois, Melanie,&Wang, Yulei.(2021).Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment.IMMUNOLOGICAL REVIEWS.
MLA	Desbois, Melanie,et al."Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment".IMMUNOLOGICAL REVIEWS (2021).