干旱区生态环境知识资源中心(Arid): Enhanced Negative Regulation of the DHH Signaling Pathway as a Potential Mechanism of Ascrotal Testes in Laurasiatherians

Arid

DOI	10.1007/s11692-021-09542-0
	Enhanced Negative Regulation of the DHH Signaling Pathway as a Potential Mechanism of Ascrotal Testes in Laurasiatherians
	Chai, Simin; Tian, Ran; Yang, Ying; Yang, Guang; Xu, Shixia; Ren, Wenhua
通讯作者	Ren, WH (corresponding author), Nanjing Normal Univ, Sch Life Sci, Jiangsu Key Lab Biodivers & Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
来源期刊	EVOLUTIONARY BIOLOGY
ISSN	0071-3260
EISSN	1934-2845
出版年	2021
英文摘要	Unsuccessful descent of testes in humans and other scrotal mammals can result in cryptorchidism, consequent abnormalities and a high risk of malignancy. However, many male adult mammals possessing natural ascrotal testes are as viable and healthy as other scrotal mammals. This study performed an evolutionary analysis on the desert hedgehog (DHH) signaling pathway, an important regulator for testicular development, mainly in laurasiatherians. Significant positive selection, accelerated evolutionary rates, and specific amino acid substitutions were identified in ascrotal species, some of which caused radical changes in physicochemical and biological properties. Considering that most signs of positive selection were identified in genes responsible for or related to negative regulation, we suggest that the enhanced negative regulation of the DHH signaling pathway drives, at least in part, the evolution of ascrotal testes in laurasiatherians and other mammals. This study could provide some novel insights into the evolution of natural healthy 'cryptorchidism' in mammals and into the convergent molecular evolution of the complex trait.
英文关键词	DHH (desert hedgehog) signaling pathway Cryptorchidism Testicular descent Leydig cells Laurasiatherians
类型	Article ; Early Access
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000655807500001
WOS关键词	DESERT-HEDGEHOG DHH ; FETAL LEYDIG-CELLS ; CONVERGENT EVOLUTION ; GONADAL-DYSGENESIS ; ECHOLOCATING BATS ; GENE ; MUTATIONS ; PREDICTION ; MAMMALS ; PATIENT
WOS类目	Evolutionary Biology
WOS研究方向	Evolutionary Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352187
作者单位	[Chai, Simin; Tian, Ran; Yang, Ying; Yang, Guang; Xu, Shixia; Ren, Wenhua] Nanjing Normal Univ, Sch Life Sci, Jiangsu Key Lab Biodivers & Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Chai, Simin,Tian, Ran,Yang, Ying,et al. Enhanced Negative Regulation of the DHH Signaling Pathway as a Potential Mechanism of Ascrotal Testes in Laurasiatherians[J],2021.
APA	Chai, Simin,Tian, Ran,Yang, Ying,Yang, Guang,Xu, Shixia,&Ren, Wenhua.(2021).Enhanced Negative Regulation of the DHH Signaling Pathway as a Potential Mechanism of Ascrotal Testes in Laurasiatherians.EVOLUTIONARY BIOLOGY.
MLA	Chai, Simin,et al."Enhanced Negative Regulation of the DHH Signaling Pathway as a Potential Mechanism of Ascrotal Testes in Laurasiatherians".EVOLUTIONARY BIOLOGY (2021).