干旱区生态环境知识资源中心(Arid): Synthesis and characterization of molecularly imprinted polymers for the selective extraction of oxazepam from complex environmental and biological samples

Arid

DOI	10.1007/s00216-021-03268-w
	Synthesis and characterization of molecularly imprinted polymers for the selective extraction of oxazepam from complex environmental and biological samples
	Varenne, Fanny; Kadhirvel, Porkodi; Bosman, Pauline; Renault, Loic; Combes, Audrey; Pichon, Valerie
通讯作者	Pichon, V (corresponding author), PSL Univ, Lab Analyt Bioanalyt Sci & Miniaturizat, Chem Biol & Innovat CBI, ESPCI Paris PSL,CNRS,UMR 8231, F-75005 Paris, France. ; Pichon, V (corresponding author), Sorbonne Univ, 4 Pl Jussieu, F-75005 Paris, France.
来源期刊	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN	1618-2642
EISSN	1618-2650
出版年	2021-03
英文摘要	Oxazepam, one of the most frequently prescribed anxiolytic drugs, is not completely removed from wastewater with conventional treatment processes. It can thus be found at trace levels in environmental water, with human urine constituting the major source of contamination. This study focused on the development and characterization of molecularly imprinted polymers (MIPs) for the selective solid-phase extraction of oxazepam at trace levels from environmental water and human urine samples. Two MIPs were synthesized, and their selectivity in pure organic and aqueous media were assayed. After optimizing the extraction procedure adapted to a large sample volume to reach a high enrichment factor, the most promising MIP was applied to the selective extraction of oxazepam from environmental water. Extraction recoveries of 83 +/- 12, 92 +/- 4 and 89 +/- 10% were obtained using the MIP for tap, mineral and river water, respectively, while a recovery close to 40% was obtained on the corresponding non-imprinted polymer (NIP). Thanks to the high enrichment factors, a limit of quantification (LOQ) of 4.5 ng L-1 was obtained for river water. A selective extraction procedure was also developed for urine samples and gave rise to extraction recoveries close to 95% for the MIP and only 23% for the NIP. Using the MIP, a LOQ of 357 ng L-1 was obtained for oxazepam in urine. The use of the MIP also helped to limit the matrix effects encountered for the quantification of oxazepam in environmental samples and in human urine samples after extraction on an Oasis HLB sorbent.
英文关键词	Benzodiazepines Molecularly imprinted polymers Solid-phase extraction LC-MS/MS Environmental water samples Human urine samples
类型	Article ; Early Access
语种	英语
开放获取类型	Green Submitted
收录类别	SCI-E
WOS记录号	WOS:000631309900003
WOS关键词	METABOLITES
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352039
作者单位	[Varenne, Fanny; Kadhirvel, Porkodi; Bosman, Pauline; Renault, Loic; Combes, Audrey; Pichon, Valerie] PSL Univ, Lab Analyt Bioanalyt Sci & Miniaturizat, Chem Biol & Innovat CBI, ESPCI Paris PSL,CNRS,UMR 8231, F-75005 Paris, France; [Pichon, Valerie] Sorbonne Univ, 4 Pl Jussieu, F-75005 Paris, France
推荐引用方式 GB/T 7714	Varenne, Fanny,Kadhirvel, Porkodi,Bosman, Pauline,et al. Synthesis and characterization of molecularly imprinted polymers for the selective extraction of oxazepam from complex environmental and biological samples[J],2021.
APA	Varenne, Fanny,Kadhirvel, Porkodi,Bosman, Pauline,Renault, Loic,Combes, Audrey,&Pichon, Valerie.(2021).Synthesis and characterization of molecularly imprinted polymers for the selective extraction of oxazepam from complex environmental and biological samples.ANALYTICAL AND BIOANALYTICAL CHEMISTRY.
MLA	Varenne, Fanny,et al."Synthesis and characterization of molecularly imprinted polymers for the selective extraction of oxazepam from complex environmental and biological samples".ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021).