干旱区生态环境知识资源中心(Arid): Calcium-Collagen Coupling is Vital for Biomineralization Schedule

Arid

DOI	10.1002/advs.202100363
	Calcium-Collagen Coupling is Vital for Biomineralization Schedule
	Zhang, Jinglun; Ji, Yaoting; Jiang, Shuting; Shi, Miusi; Cai, Wenjin; Miron, Richard J.; Zhang, Yufeng
通讯作者	Zhang, YF (corresponding author), Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan 430079, Peoples R China. ; Zhang, YF (corresponding author), Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Peoples R China.
来源期刊	ADVANCED SCIENCE
EISSN	2198-3844
出版年	2021
英文摘要	Biomineralization is a chemical reaction that occurs in organisms in which collagen initiates and guides the growth and crystallization of matched apatite minerals. However, there is little known about the demand pattern for calcium salts and collagen needed by biomineralization. In this study, natural bone biomineralization is analyzed, and a novel interplay between calcium concentration and collagen production is observed. Any quantitative change in one of the entities causes a corresponding change in the other. Translocation-associated membrane protein 2 (TRAM2) is identified as an intermediate factor whose silencing disrupts this relationship and causes poor mineralization. TRAM2 directly interacts with the sarcoplasmic/endoplasmic reticulum calcium ATPase 2b (SERCA2b) and modulates SERCA2b activity to couple calcium enrichment with collagen biosynthesis. Collectively, these findings indicate that osteoblasts can independently and directly regulate the process of biomineralization via this coupling. This knowledge has significant implications for the developmentally inspired design of biomaterials for bone regenerative applications.
英文关键词	biomineralization bones bone biomaterials calcium– collagen coupling collagen
类型	Article ; Early Access
语种	英语
开放获取类型	DOAJ Gold
收录类别	SCI-E
WOS记录号	WOS:000655406200001
WOS关键词	UNFOLDED PROTEIN RESPONSE ; BONE ; HOMEOSTASIS ; NUCLEATION ; PHOSPHATE ; PACKAGE ; STRESS ; GROWTH ; CELLS ; OASIS
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352025
作者单位	[Zhang, Jinglun; Ji, Yaoting; Jiang, Shuting; Shi, Miusi; Cai, Wenjin; Zhang, Yufeng] Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan 430079, Peoples R China; [Zhang, Jinglun; Ji, Yaoting; Jiang, Shuting; Shi, Miusi; Cai, Wenjin; Zhang, Yufeng] Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Peoples R China; [Miron, Richard J.] Nova Southeastern Univ, Cell Therapy Inst, Ctr Collaborat Res, Ft Lauderdale, FL 33314 USA; [Miron, Richard J.] Nova Southeastern Univ, Coll Dent Med, Dept Periodontol, Ft Lauderdale, FL 33314 USA; [Miron, Richard J.] Univ Ann Arbor, Dept Periodont & Oral Surg, Ann Arbor, MI 48109 USA
推荐引用方式 GB/T 7714	Zhang, Jinglun,Ji, Yaoting,Jiang, Shuting,et al. Calcium-Collagen Coupling is Vital for Biomineralization Schedule[J],2021.
APA	Zhang, Jinglun.,Ji, Yaoting.,Jiang, Shuting.,Shi, Miusi.,Cai, Wenjin.,...&Zhang, Yufeng.(2021).Calcium-Collagen Coupling is Vital for Biomineralization Schedule.ADVANCED SCIENCE.
MLA	Zhang, Jinglun,et al."Calcium-Collagen Coupling is Vital for Biomineralization Schedule".ADVANCED SCIENCE (2021).