干旱区生态环境知识资源中心(Arid): Effectiveness of ocriplasmin in real-world settings: A systematic literature review, meta-analysis, and comparison with randomized trials

Arid

DOI	10.1111/aos.14686
	Effectiveness of ocriplasmin in real-world settings: A systematic literature review, meta-analysis, and comparison with randomized trials
	Khanani, Arshad M.; Constantine, Ryan N.; Blot, Koenraad H.; Lescrauwaet, Benedicte; Szurman, Peter
通讯作者	Khanani, AM (corresponding author), Sierra Eye Associates, 950 Ryland St, Reno, NV 89502 USA.
来源期刊	ACTA OPHTHALMOLOGICA
ISSN	1755-375X
EISSN	1755-3768
出版年	2021
英文摘要	Purpose Effectiveness of ocriplasmin for vitreomacular traction (VMT) varies depending on the presence of common ocular conditions and patient selection criteria. We carried out a systematic literature review and meta-analysis of ocriplasmin studies conducted in real-world settings (RWS) and compared outcomes with those from randomized controlled trials (RCTs). Methods We included prospective and retrospective studies from RWS documenting effectiveness of ocriplasmin in patients with VMT with or without MH, and RCTs of ocriplasmin versus control. Key end-points were vitreomacular adhesion resolution (VMAR), nonsurgical MH closure, need for vitrectomy and safety. We conducted meta-regression on pooled results to evaluate effects of baseline covariates and study design on outcomes. Results Thirty RWS (2402 patients) and 5 RCTs (737 patients) were included epiretinal membrane (ERM) and broad VMA were more prevalent in RCTs. Primary VMAR, vitrectomy and MH closure rates were comparable between RWS and RCTs. Rates of nsVMAR were significantly higher in RWS than RCTs (odds ratio 1.66; 95% confidence interval [CI]: 1.18-2.34). nsVMAR rates were inversely associated with ERM prevalence (odds ratio 0.20; 95% CI: 0.08-0.51). Compared with the recent OASIS trial, RWS reported a higher incidence of new/worsening subretinal fluid cases and less photophobia, photopsia, vitreous floaters, electroretinogram abnormalities and MH progression. Conclusions Ocriplasmin was significantly more effective in achieving nsVMAR in RWS than in RCTs. Lower ERM prevalence in RWS was the single significant explanatory variable for this difference. Conclusions on ocriplasmin safety in RWS are limited due to inconsistent reporting.
英文关键词	Ocriplasmin vitreomacular traction effectiveness real world
类型	Review ; Early Access
语种	英语
开放获取类型	Other Gold
收录类别	SCI-E
WOS记录号	WOS:000601916600001
WOS关键词	VITREOMACULAR TRACTION ; INTRAVITREAL OCRIPLASMIN ; MACULAR HOLE ; LIFE EXPERIENCE ; VISUAL OUTCOMES ; INJECTION ; ADHESION ; EFFICACY ; COMPLICATIONS ; PREDICTORS
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352024
作者单位	[Khanani, Arshad M.; Constantine, Ryan N.] Sierra Eye Associates, 950 Ryland St, Reno, NV 89502 USA; [Blot, Koenraad H.; Lescrauwaet, Benedicte] Xintera BV, Ghent, Belgium; [Szurman, Peter] Knappschaft Hosp Saar, Eye Clin Sulzbach, Sulzbach, Germany; [Szurman, Peter] Klaus Heimann Eye Res Inst KHERI, Sulzbach, Germany
推荐引用方式 GB/T 7714	Khanani, Arshad M.,Constantine, Ryan N.,Blot, Koenraad H.,et al. Effectiveness of ocriplasmin in real-world settings: A systematic literature review, meta-analysis, and comparison with randomized trials[J],2021.
APA	Khanani, Arshad M.,Constantine, Ryan N.,Blot, Koenraad H.,Lescrauwaet, Benedicte,&Szurman, Peter.(2021).Effectiveness of ocriplasmin in real-world settings: A systematic literature review, meta-analysis, and comparison with randomized trials.ACTA OPHTHALMOLOGICA.
MLA	Khanani, Arshad M.,et al."Effectiveness of ocriplasmin in real-world settings: A systematic literature review, meta-analysis, and comparison with randomized trials".ACTA OPHTHALMOLOGICA (2021).