干旱区生态环境知识资源中心(Arid): Venom-Induced Consumption Coagulopathy Unresponsive to Antivenom After Echis carinatus sochureki Envenoming

Arid

	Venom-Induced Consumption Coagulopathy Unresponsive to Antivenom After Echis carinatus sochureki Envenoming
	Gopalakrishnan, Maya; Yadav, Prakrati; Mathur, Rohit; Midha, Naresh; Garg, Mahendra Kumar
通讯作者	Gopalakrishnan, M (corresponding author), All India Inst Med Sci AIIMS, Dept Med, Jodhpur 342005, Rajasthan, India.
来源期刊	WILDERNESS & ENVIRONMENTAL MEDICINE
ISSN	1080-6032
EISSN	1545-1534
出版年	2021
卷号	32 期号:2 页码:221-225
英文摘要	Snakebite envenoming is a serious and life-threatening but neglected problem in the tropics. The focus in the Indian subcontinent is usually on the Indian cobra (Naja naja), common krait (Bungarus caeruleus), Russell's viper (Daboia russelii), and Indian saw-scaled viper (Echis carinatus). The Indian polyvalent antivenom contains hyperimmunized horse antibodies against only these 4 species. However, regional intraspecific variations are important in viper envenomings, leading to marked differences in clinical presentation and response to the available polyvalent antivenom. Echis carinatus sochureki, a subspecies of Echis carinatus, has been linked to serious morbidity in the Thar Desert regions of Rajasthan, although consistent reports are lacking. We report a patient with prolonged venom-induced consumption coagulopathy owing to Echis carinatus sochureki envenoming who did not respond to Indian polyvalent antivenom in Jodhpur, India. Features of local and hemotoxic envenoming resolved after a week with supportive care. Echis sochureki venom has been shown to be different from Echis carinatus in terms of composition and in vitro neutralization by antivenom. Clinicians in the tropical desert regions must suspect Echis sochureki envenoming in the setting of nonresponsiveness to Indian polyvalent antivenom. This will help optimize antivenom use in these patients, preventing potentially life-threatening antivenom associated reactions. Because the usefulness of Indian polyvalent antivenom appears to be limited in this setting, there is an urgent need to advocate for region-specific antivenom or monovalent antivenom for this area.
英文关键词	snakebite saw-scaled viper arid desert
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000661408000014
WOS关键词	RAJASTHAN ; DESERT ; INDIA
WOS类目	Public, Environmental & Occupational Health ; Sport Sciences
WOS研究方向	Public, Environmental & Occupational Health ; Sport Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352002
作者单位	[Gopalakrishnan, Maya; Yadav, Prakrati; Mathur, Rohit; Midha, Naresh; Garg, Mahendra Kumar] All India Inst Med Sci AIIMS, Dept Internal Med, Jodhpur, Rajasthan, India
推荐引用方式 GB/T 7714	Gopalakrishnan, Maya,Yadav, Prakrati,Mathur, Rohit,et al. Venom-Induced Consumption Coagulopathy Unresponsive to Antivenom After Echis carinatus sochureki Envenoming[J],2021,32(2):221-225.
APA	Gopalakrishnan, Maya,Yadav, Prakrati,Mathur, Rohit,Midha, Naresh,&Garg, Mahendra Kumar.(2021).Venom-Induced Consumption Coagulopathy Unresponsive to Antivenom After Echis carinatus sochureki Envenoming.WILDERNESS & ENVIRONMENTAL MEDICINE,32(2),221-225.
MLA	Gopalakrishnan, Maya,et al."Venom-Induced Consumption Coagulopathy Unresponsive to Antivenom After Echis carinatus sochureki Envenoming".WILDERNESS & ENVIRONMENTAL MEDICINE 32.2(2021):221-225.