干旱区生态环境知识资源中心(Arid): Dropouts in randomized clinical trials of Korean medicine interventions: a systematic review and meta-analysis

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DOI	10.1186/s13063-021-05114-x
	Dropouts in randomized clinical trials of Korean medicine interventions: a systematic review and meta-analysis
	Jeon, Sae-rom; Nam, Dongwoo; Kim, Tae-Hun
通讯作者	Kim, TH (corresponding author), Kyung Hee Univ, Grad Sch, Dept Clin Korean Med, 26 Kyung Heedae Ro, Seoul 02447, South Korea. ; Kim, TH (corresponding author), Kyung Hee Univ, Dept Korea8n Med Clin Trial Ctr, Coll Korean Med, 23 Kyung Heedae Ro, Seoul 02447, South Korea.
来源期刊	TRIALS
EISSN	1745-6215
出版年	2021
卷号	22 期号:1
英文摘要	Background: The dropout rate is an important determinant of outcomes in randomized controlled trials (RCTs) and should be carefully controlled. This study explored the current dropout rate in studies of Korean medicine (KM) interventions by systematic evaluation of RCTs conducted in the past 10years. Methods: Three clinical trial registries (Clinical Research Information Service, ClinicalTrials.gov, and World Health Organization International Clinical Trials Registry Platform) were searched to identify RCT protocols for KM interventions, such as acupuncture, herbal medicine, moxibustion, or cupping, and studies of mixed interventions, registered in Korea from 2009 to 2019. The PubMed, Embase, and OASIS databases were searched for the full reports of these RCTs, including published journal articles and theses. Dropout rates and the reasons for dropping out were analyzed in each report. The risk of bias in each of the included studies was assessed using the Cochrane risk of bias tool. The risk difference for dropping out between the treatment and control groups was calculated with the 95% confidence interval in a random effects model. Results: Forty-nine published studies were included in the review. The median dropout rate was 10% in the treatment group (interquartile range 6.7%, 17.0%) and 14% in the control group (interquartile range 5.4%, 16.3%) and was highest in acupuncture studies (12%), followed by herbal medicine (10%), moxibustion (8%), and cupping (7%). Loss to follow-up was the most common reason for dropping out. The risk difference for dropping out between the intervention and control groups was estimated to be 0.01 (95% confidence interval -0.02, 0.03) in KM intervention studies. Conclusions: This review found no significant difference in the dropout rate between studies according to the type of KM intervention. We recommend allowance for a minimum dropout rate of 15% in future RCTs of KM interventions. Review protocol registration: PROSPERO CRD42020141011
英文关键词	Randomized clinical trials Dropouts Korean medicine Acupuncture Herbal medicine Systematic review Meta-analysis Risk difference
类型	Review
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000625387800006
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351910
作者单位	[Jeon, Sae-rom; Nam, Dongwoo; Kim, Tae-Hun] Kyung Hee Univ, Grad Sch, Dept Clin Korean Med, 26 Kyung Heedae Ro, Seoul 02447, South Korea; [Kim, Tae-Hun] Kyung Hee Univ, Dept Korea8n Med Clin Trial Ctr, Coll Korean Med, 23 Kyung Heedae Ro, Seoul 02447, South Korea
推荐引用方式 GB/T 7714	Jeon, Sae-rom,Nam, Dongwoo,Kim, Tae-Hun. Dropouts in randomized clinical trials of Korean medicine interventions: a systematic review and meta-analysis[J],2021,22(1).
APA	Jeon, Sae-rom,Nam, Dongwoo,&Kim, Tae-Hun.(2021).Dropouts in randomized clinical trials of Korean medicine interventions: a systematic review and meta-analysis.TRIALS,22(1).
MLA	Jeon, Sae-rom,et al."Dropouts in randomized clinical trials of Korean medicine interventions: a systematic review and meta-analysis".TRIALS 22.1(2021).