干旱区生态环境知识资源中心(Arid): Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture

Arid

DOI	10.3390/toxins13020112
	Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture
	Op den Brouw, Bianca; Coimbra, Francisco C. P.; Bourke, Lachlan A.; Huynh, Tam Minh; Vlecken, Danielle H. W.; Ghezellou, Parviz; Visser, Jeroen C.; Dobson, James S.; Fernandez-Rojo, Manuel A.; Ikonomopoulou, Maria P.; Casewell, Nicholas R.; Ali, Syed A.; Fathinia, Behzad; Hodgson, Wayne C.; Fry, Bryan G.
通讯作者	Op den Brouw, B ; Fry, BG (corresponding author), Univ Queensland, Sch Biol Sci, Venom Evolut Lab, St Lucia, Qld 4072, Australia.
来源期刊	TOXINS
EISSN	2072-6651
出版年	2021
卷号	13 期号:2
英文摘要	Snakes of the genera Pseudocerastes and Eristicophis (Viperidae: Viperinae) are known as the desert vipers due to their association with the arid environments of the Middle East. These species have received limited research attention and little is known about their venom or ecology. In this study, a comprehensive analysis of desert viper venoms was conducted by visualising the venom proteomes via gel electrophoresis and assessing the crude venoms for their cytotoxic, haemotoxic, and neurotoxic properties. Plasmas sourced from human, toad, and chicken were used as models to assess possible prey-linked venom activity. The venoms demonstrated substantial divergence in composition and bioactivity across all experiments. Pseudocerastes urarachnoides venom activated human coagulation factors X and prothrombin and demonstrated potent procoagulant activity in human, toad, and chicken plasmas, in stark contrast to the potent neurotoxic venom of P. fieldi. The venom of E. macmahonii also induced coagulation, though this did not appear to be via the activation of factor X or prothrombin. The coagulant properties of P. fieldi and P. persicus venoms varied among plasmas, demonstrating strong anticoagulant activity in the amphibian and human plasmas but no significant effect in that of bird. This is conjectured to reflect prey-specific toxin activity, though further ecological studies are required to confirm any dietary associations. This study reinforces the notion that phylogenetic relatedness of snakes cannot readily predict venom protein composition or function. The significant venom variation between these species raises serious concerns regarding antivenom paraspecificity. Future assessment of antivenom is crucial.
英文关键词	Pseudocerastes Eristicophis venom haemotoxic neurotoxic cytotoxic venom variation
类型	Article
语种	英语
开放获取类型	Green Published, Green Accepted, gold
收录类别	SCI-E
WOS记录号	WOS:000623289000001
WOS类目	Food Science & Technology ; Toxicology
WOS研究方向	Food Science & Technology ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351896
作者单位	[Op den Brouw, Bianca; Coimbra, Francisco C. P.; Bourke, Lachlan A.; Visser, Jeroen C.; Dobson, James S.; Fry, Bryan G.] Univ Queensland, Sch Biol Sci, Venom Evolut Lab, St Lucia, Qld 4072, Australia; [Huynh, Tam Minh; Hodgson, Wayne C.] Monash Univ, Fac Med Nursing & Hlth Sci, Monash Venom Grp, Clayton, Vic 3800, Australia; [Vlecken, Danielle H. W.] Inst Biol Leiden, Dept Anim Sci & Hlth, NL-2333 BE Leiden, Netherlands; [Ghezellou, Parviz] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Tehran 1983969411, Iran; [Ghezellou, Parviz] Justus Liebig Univ Giessen, Inst Inorgan & Analyt Chem, D-35392 Giessen, Germany; [Fernandez-Rojo, Manuel A.; Ikonomopoulou, Maria P.] Madrid Inst Adv Studies Food, E-28049 Madrid, Spain; [Fernandez-Rojo, Manuel A.; Ikonomopoulou, Maria P.] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia; [Casewell, Nicholas R.] Univ Liverpool Liverpool Sch Trop Med, Ctr Snakebite Res & Intervent, Liverpool L3 5QA, Merseyside, England; [Ali, Syed A.] Univ Karachi, Int Ctr Che...
推荐引用方式 GB/T 7714	Op den Brouw, Bianca,Coimbra, Francisco C. P.,Bourke, Lachlan A.,et al. Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture[J],2021,13(2).
APA	Op den Brouw, Bianca.,Coimbra, Francisco C. P..,Bourke, Lachlan A..,Huynh, Tam Minh.,Vlecken, Danielle H. W..,...&Fry, Bryan G..(2021).Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture.TOXINS,13(2).
MLA	Op den Brouw, Bianca,et al."Extensive Variation in the Activities of Pseudocerastes and Eristicophis Viper Venoms Suggests Divergent Envenoming Strategies Are Used for Prey Capture".TOXINS 13.2(2021).