干旱区生态环境知识资源中心(Arid): Tissue-specific regulatory mechanism of LncRNAs and methylation in sheep adipose and muscle induced by Allium mongolicum Regel extracts

Arid

DOI	10.1038/s41598-021-88444-9
	Tissue-specific regulatory mechanism of LncRNAs and methylation in sheep adipose and muscle induced by Allium mongolicum Regel extracts
	Xue, Jiangdong; Lv, Qi; Khas, Erdene; Bai, Chen; Ma, Bingjie; Li, Wangjiao; Cao, Qina; Fan, Zejun; Ao, Changjin
通讯作者	Ao, CJ (corresponding author), Inner Mongolia Agr Univ, Inner Mongolia Key Lab Anim Nutr & Feed Sci, Coll Anim Sci, Hohhot 010018, Peoples R China.
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2021
卷号	11 期号:1
英文摘要	Allium mongolicum Regel (A. mongolicum) is a perennial and xerophytic Liliaceous allium plant in high altitude desert steppe and desert areas. Feeding A. mongolicum greatly reduced unpleasant mutton flavor and improves meat quality of sheep. We analyzed epigenetic regulatory mechanisms of water extracts of A. mongolicum (WEA) on sheep muscle and adipose using RNA-Seq and whole-genome Bisulfite sequencing. Feeding WEA reduced differentially expressed genes and long non-coding RNAs (lncRNAs) between two tissues but increased differentially methylation regions (DMRs). LncRNA and DMR targets were both involved in ATP binding, ubiquitin, protein kinase binding, regulation of cell proliferation, and related signaling pathways, but not unsaturated fatty acids metabolism. Besides, tissue specific targets were involved in distinct functional annotations, e.g., Golgi membrane and endoplasmic reticulum for muscle lncRNA, oxidative phosphorylation metabolism for adipose lncRNA, dsRNA binding for muscle DMRs. Epigenetic regulatory networks were also discovered to discovered essential co-regulated modules, e.g., co-regulated insulin secretion module (PDPK1, ATP1A2, CACNA1S and CAMK2D) in adipose. The results indicated that WEA induced distinct epigenetic regulation on muscle and adipose to diminish transcriptome differences between tissues, which highlights biological functions of A. mongolicum, tissue similarity and specificity, as well as regulatory mechanism of mutton odor.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000656067200008
WOS关键词	RNA-SEQ EXPERIMENTS ; EPIGENETIC REGULATION ; EXPRESSION ANALYSIS ; GENE-EXPRESSION ; DNA METHYLATION ; REVEALS ; HISTORY ; HEALTH ; BRAIN
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351724
作者单位	[Xue, Jiangdong; Lv, Qi; Khas, Erdene; Bai, Chen; Cao, Qina; Fan, Zejun; Ao, Changjin] Inner Mongolia Agr Univ, Inner Mongolia Key Lab Anim Nutr & Feed Sci, Coll Anim Sci, Hohhot 010018, Peoples R China; [Xue, Jiangdong] Inner Mongolia Univ Nationalities, Coll Anim Sci & Technol, Tongliao 028000, Peoples R China; [Lv, Qi; Ma, Bingjie; Li, Wangjiao] Inner Mongolia Agr Univ, Coll Anim Sci, Key Lab Anim Genet Breeding & Reprod Inner Mongol, Hohhot 010018, Peoples R China
推荐引用方式 GB/T 7714	Xue, Jiangdong,Lv, Qi,Khas, Erdene,et al. Tissue-specific regulatory mechanism of LncRNAs and methylation in sheep adipose and muscle induced by Allium mongolicum Regel extracts[J],2021,11(1).
APA	Xue, Jiangdong.,Lv, Qi.,Khas, Erdene.,Bai, Chen.,Ma, Bingjie.,...&Ao, Changjin.(2021).Tissue-specific regulatory mechanism of LncRNAs and methylation in sheep adipose and muscle induced by Allium mongolicum Regel extracts.SCIENTIFIC REPORTS,11(1).
MLA	Xue, Jiangdong,et al."Tissue-specific regulatory mechanism of LncRNAs and methylation in sheep adipose and muscle induced by Allium mongolicum Regel extracts".SCIENTIFIC REPORTS 11.1(2021).