干旱区生态环境知识资源中心(Arid): Genomic prediction for growth using a low-density SNP panel in dromedary camels

Arid

DOI	10.1038/s41598-021-87296-7
	Genomic prediction for growth using a low-density SNP panel in dromedary camels
	Sani, Morteza Bitaraf; Harofte, Javad Zare; Banabazi, Mohammad Hossein; Esmaeilkhanian, Saeid; Naderi, Ali Shafei; Salim, Nader; Teimoori, Abbas; Bitaraf, Ahmad; Zadehrahmani, Mohammad; Burger, Pamela Anna; Landi, Vincenzo; Silawi, Mohammad; Sheshdeh, Afsaneh Taghipour; Faghihi, Mohammad Ali
通讯作者	Sani, MB (corresponding author), Agr Res Educ & Extens Org AREEO, Yazd Agr & Nat Resources Res & Educ Ctr, Anim Sci Res Dept, Yazd 8915813155, Iran.
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2021
卷号	11 期号:1
英文摘要	For thousands of years, camels have produced meat, milk, and fiber in harsh desert conditions. For a sustainable development to provide protein resources from desert areas, it is necessary to pay attention to genetic improvement in camel breeding. By using genotyping-by-sequencing (GBS) method we produced over 14,500 genome wide markers to conduct a genome- wide association study (GWAS) for investigating the birth weight, daily gain, and body weight of 96 dromedaries in the Iranian central desert. A total of 99 SNPs were associated with birth weight, daily gain, and body weight (p-value<0.002). Genomic breeding values (GEBVs) were estimated with the BGLR package using (i) all 14,522 SNPs and (ii) the 99 SNPs by GWAS. Twenty-eight SNPs were associated with birth weight, daily gain, and body weight (p-value<0.001). Annotation of the genomic region (s) within +/- 100 kb of the associated SNPs facilitated prediction of 36 candidate genes. The accuracy of GEBVs was more than 0.65 based on all 14,522 SNPs, but the regression coefficients for birth weight, daily gain, and body weight were 0.39, 0.20, and 0.23, respectively. Because of low sample size, the GEBVs were predicted using the associated SNPs from GWAS. The accuracy of GEBVs based on the 99 associated SNPs was 0.62, 0.82, and 0.57 for birth weight, daily gain, and body weight. This report is the first GWAS using GBS on dromedary camels and identifies markers associated with growth traits that could help to plan breeding program to genetic improvement. Further researches using larger sample size and collaboration of the camel farmers and more profound understanding will permit verification of the associated SNPs identified in this project. The preliminary results of study show that genomic selection could be the appropriate way to genetic improvement of body weight in dromedary camels, which is challenging due to a long generation interval, seasonal reproduction, and lack of records and pedigrees.
类型	Article
语种	英语
开放获取类型	gold, Green Published, Green Submitted
收录类别	SCI-E
WOS记录号	WOS:000640395800039
WOS关键词	MARKER-ASSISTED SELECTION ; WIDE ASSOCIATION ; BEEF-CATTLE ; BREEDING VALUES ; COMPLEX TRAITS ; CARCASS ; WEIGHT ; INFORMATION ; PERFORMANCE ; REGRESSION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351720
作者单位	[Sani, Morteza Bitaraf; Harofte, Javad Zare; Naderi, Ali Shafei; Bitaraf, Ahmad] Agr Res Educ & Extens Org AREEO, Yazd Agr & Nat Resources Res & Educ Ctr, Anim Sci Res Dept, Yazd 8915813155, Iran; [Banabazi, Mohammad Hossein; Esmaeilkhanian, Saeid] Agr Res Educ & Extens Org AREEO, Anim Sci Res Inst IRAN ASRI, Dept Biotechnol, Karaj 3146618361, Iran; [Salim, Nader; Teimoori, Abbas] Minist Agr Jahad, Org Agr Jahad Yazd, Yazd 8916713449, Iran; [Zadehrahmani, Mohammad] Yazd Dar Al Elm Higher Educ Inst, Yazd, Iran; [Burger, Pamela Anna] Vetmeduni Vienna, Res Inst Wildlife Ecol, A-1160 Vienna, Austria; [Landi, Vincenzo] Univ Bari Aldo Moro, Dept Vet Med, Bari, Italy; [Silawi, Mohammad; Sheshdeh, Afsaneh Taghipour; Faghihi, Mohammad Ali] Persian BayanGene Res & Training Cent, Shiraz 7134767617, Iran; [Faghihi, Mohammad Ali] Univ Miami, Ctr Therapeut Innovat, Miami, FL 33136 USA; [Faghihi, Mohammad Ali] Univ Miami, Dept Psychiat & Behav Sci, Miami, FL 33136 USA
推荐引用方式 GB/T 7714	Sani, Morteza Bitaraf,Harofte, Javad Zare,Banabazi, Mohammad Hossein,et al. Genomic prediction for growth using a low-density SNP panel in dromedary camels[J],2021,11(1).
APA	Sani, Morteza Bitaraf.,Harofte, Javad Zare.,Banabazi, Mohammad Hossein.,Esmaeilkhanian, Saeid.,Naderi, Ali Shafei.,...&Faghihi, Mohammad Ali.(2021).Genomic prediction for growth using a low-density SNP panel in dromedary camels.SCIENTIFIC REPORTS,11(1).
MLA	Sani, Morteza Bitaraf,et al."Genomic prediction for growth using a low-density SNP panel in dromedary camels".SCIENTIFIC REPORTS 11.1(2021).