Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.1016/j.rmr.2020.11.007 |
| Adaption to chronic hypoxaemia by populations living at high altitude | |
| Richalet, J-P | |
| 通讯作者 | Richalet, JP (corresponding author), Univ Sorbonne Paris Nord 13, Lab Hypoxie & Poumon, UMR Inserm U1272, 74 Rue Marcel Cachin, F-93017 Bobigny, France. |
| 来源期刊 | REVUE DES MALADIES RESPIRATOIRES
 |
| ISSN | 0761-8425 |
| EISSN | 1776-2588 |
| 出版年 | 2021 |
| 卷号 | 38期号:4页码:395-403 |
| 英文摘要 | Permanent life at high altitude induces important physiological stresses linked to the exposure to chronic hypoxia. Various strategies have been adopted by diverse populations living in the Andes, Tibet or East Africa. The main mechanism is an increase in red blood cell production, more marked in Andeans than in Tibetans or Ethiopians. Other changes are observed in the cardiovascular or respiratory systems, as well as in the utero-placental circulation. Sometimes, a de-adaptation process to hypoxia develops, when erythrocytosis becomes excessive and leads to haematological, vascular and cerebral complications (Monge's disease or chronic mountain sickness). Pulmonary hypertension may also appear. Therapeutic options are available but not sufficiently used. Genetic studies have recently been undertaken to try to better understand the evolution of the human genome in populations living in various high altitude regions of the world, as well as the genetic risk factors for chronic diseases. A new model has appeared, intermittent chronic hypoxia, due to the development of economic activities (mainly mining) in desert regions of the Altiplano. (C) 2020 SPLF. Published by Elsevier Masson SAS. All rights reserved. |
| 英文关键词 | Hypoxia Altitude Genetics Chronic mountain sickness |
| 类型 | Article |
| 语种 | 法语 |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000644695000007 |
| WOS关键词 | CHRONIC MOUNTAIN-SICKNESS ; CHRONIC INTERMITTENT EXPOSURE ; GENETIC-BASIS ; OXYGEN-TRANSPORT ; CLINICAL-ASPECTS ; CHRONIC HYPOXIA ; MONGES-DISEASE ; CHILEAN MINERS ; ADAPTATION ; EXERCISE |
| WOS类目 | Respiratory System |
| WOS研究方向 | Respiratory System |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/351598 |
| 作者单位 | [Richalet, J-P] Univ Sorbonne Paris Nord 13, Lab Hypoxie & Poumon, UMR Inserm U1272, 74 Rue Marcel Cachin, F-93017 Bobigny, France |
| 推荐引用方式 GB/T 7714 | Richalet, J-P. Adaption to chronic hypoxaemia by populations living at high altitude[J],2021,38(4):395-403. |
| APA | Richalet, J-P.(2021).Adaption to chronic hypoxaemia by populations living at high altitude.REVUE DES MALADIES RESPIRATOIRES,38(4),395-403. |
| MLA | Richalet, J-P."Adaption to chronic hypoxaemia by populations living at high altitude".REVUE DES MALADIES RESPIRATOIRES 38.4(2021):395-403. |
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