干旱区生态环境知识资源中心(Arid): Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya

Arid

DOI	10.1371/journal.pntd.0009275
	Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya
	Muturi, Mathew; Akoko, James; Nthiwa, Daniel; Chege, Bernard; Nyamota, Richard; Mutiiria, Mathew; Maina, Josphat; Thumbi, S. M.; Nyamai, Mutono; Kahariri, Samuel; Sitawa, Rinah; Kimutai, Joshua; Kuria, Wilson; Mwatondo, Athman; Bett, Bernard
通讯作者	Muturi, M (corresponding author), Zoonot Dis Unit Nairobi, Nairobi, Kenya. ; Muturi, M (corresponding author), Int Livestock Res Inst, Nairobi, Kenya.
来源期刊	PLOS NEGLECTED TROPICAL DISEASES
ISSN	1935-2735
出版年	2021
卷号	15 期号:3
英文摘要	Author summary Dromedary camels are well adapted to the arid and semi-arid environment that makes up about 80% of Kenya's landmass. As such, camels play an important role in the socio-economic wellbeing and food security of pastoralists in the country. However, the species remains relatively neglected in scientific research, one of the main reasons being camels are mostly found in remote, low-income, arid regions of Africa and Asia. We carried out a study to determine the levels of exposure of camels in northern Kenya to Brucella spp., Coxiella burnetii and Rift Valley fever virus, three priority zoonotic pathogens in the country. We found high levels of exposure to the three pathogens, indicating the important role camels might play in the epidemiology of the zoonotic diseases in humans and other livestock. Based on the study findings, we argue for the immediate need for investments in disease surveillance and control strategies for priority zoonotic disease in camels in Kenya. Camels are increasingly becoming the livestock of choice for pastoralists reeling from effects of climate change in semi-arid and arid parts of Kenya. As the population of camels rises, better understanding of their role in the epidemiology of zoonotic diseases in Kenya is a public health priority. Rift Valley fever (RVF), brucellosis and Q fever are three of the top priority diseases in the country but the involvement of camels in the transmission dynamics of these diseases is poorly understood. We analyzed 120 camel serum samples from northern Kenya to establish seropositivity rates of the three pathogens and to characterize the infecting Brucella species using molecular assays. We found seropositivity of 24.2% (95% confidence interval [CI]: 16.5-31.8%) for Brucella, 20.8% (95% CI: 13.6-28.1%) and 14.2% (95% CI: 7.9-20.4%) for Coxiella burnetii and Rift valley fever virus respectively. We found 27.5% (95% CI: 19.5-35.5%) of the animals were seropositive for at least one pathogen and 13.3% (95% CI: 7.2-19.4%) were seropositive for at least two pathogens. B. melitensis was the only Brucella spp. detected. The high sero-positivity rates are indicative of the endemicity of these pathogens among camel populations and the possible role the species has in the epidemiology of zoonotic diseases. Considering the strong association between human infection and contact with livestock for most zoonotic infections in Kenya, there is immediate need to conduct further research to determine the role of camels in transmission of these zoonoses to other livestock species and humans. This information will be useful for designing more effective surveillance systems and intervention measures.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000634795100002
WOS关键词	LAIKIPIA COUNTY ; DISEASE ; EPIDEMIOLOGY ; PATHOGENESIS ; ASSOCIATION ; IMPACT ; CATTLE ; RISK
WOS类目	Infectious Diseases ; Parasitology ; Tropical Medicine
WOS研究方向	Infectious Diseases ; Parasitology ; Tropical Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351373
作者单位	[Muturi, Mathew; Chege, Bernard; Mutiiria, Mathew; Maina, Josphat; Mwatondo, Athman] Zoonot Dis Unit Nairobi, Nairobi, Kenya; [Muturi, Mathew; Akoko, James; Nyamota, Richard; Maina, Josphat; Mwatondo, Athman; Bett, Bernard] Int Livestock Res Inst, Nairobi, Kenya; [Nthiwa, Daniel] Univ Embu, Dept Biol Sci, Embu, Kenya; [Thumbi, S. M.; Nyamai, Mutono] Univ Nairobi, Ctr Epidemiol & Modelling Anal, Inst Trop & Infect Dis, Nairobi, Kenya; [Thumbi, S. M.] Univ Edinburgh, Inst Immunol & Infect Res, Edinburgh, Midlothian, Scotland; [Thumbi, S. M.; Nyamai, Mutono] Washington State Univ, Paul G Allen Sch Global Hlth, Pullman, WA 99164 USA; [Kahariri, Samuel; Kuria, Wilson] Minist Agr Livestock & Fisheries, Kenya Directorate Vet Serv, Nairobi, Kenya; [Sitawa, Rinah; Kimutai, Joshua] Food & Agr Org United Nat, Nairobi, Kenya
推荐引用方式 GB/T 7714	Muturi, Mathew,Akoko, James,Nthiwa, Daniel,et al. Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya[J],2021,15(3).
APA	Muturi, Mathew.,Akoko, James.,Nthiwa, Daniel.,Chege, Bernard.,Nyamota, Richard.,...&Bett, Bernard.(2021).Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya.PLOS NEGLECTED TROPICAL DISEASES,15(3).
MLA	Muturi, Mathew,et al."Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya".PLOS NEGLECTED TROPICAL DISEASES 15.3(2021).