干旱区生态环境知识资源中心(Arid): Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae)

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DOI	10.1016/j.phytochem.2021.112701
	Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae)
	Zhang, Xiao-Yan; Tan, Xiang-Mei; Yu, Meng; Yang, Jian; Sun, Bing-Da; Qin, Jian-Chun; Guo, Lan-Ping; Ding, Gang
通讯作者	Ding, G (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China. ; Guo, LP (corresponding author), China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, Beijing 100700, Peoples R China. ; Qin, JC (corresponding author), Jilin Univ, Coll Plant Sci, Changchun 130062, Jilin, Peoples R China.
来源期刊	PHYTOCHEMISTRY
ISSN	0031-9422
EISSN	1873-3700
出版年	2021
卷号	185
英文摘要	Globosumin, an undescribed chromene-4,7(4aH)-dione-tetramic acid PKS-PKS-NRPS hybrid, and globosumone, an undescribed azaphilone, together with ten known metabolites, were isolated from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae). The planar structures and relative configurations of globosumin and globosumone were determined by high-resolution ESI-MS and NMR data, and the absolute configurations of these two metabolites were determined by electronic circular dichroism (ECD) and circular dichroism (CD) combined with time-dependent density functional theory (TDDFT)-based quantum-chemical calculations. Chaetoglobosin A displayed biological effects against the seedling growth of Arabidopsis thaliana (Brassicaceae) in a dose-dependent manner, and this compound also exhibited biological activity against two cancer cell lines, A549 and HepG2, with IC50 values of 6.82 +/- 2.34 and 38.62 +/- 7.44 mu M, respectively.
英文关键词	Desert plant Artemisia desterorum Asteraceae Endophytic fungus Chaetomium globosum Chaetomiaceae Globosumin Globosumone Bioactivities
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000639166000002
WOS类目	Biochemistry & Molecular Biology ; Plant Sciences
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351321
作者单位	[Zhang, Xiao-Yan; Tan, Xiang-Mei; Yu, Meng; Ding, Gang] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100193, Peoples R China; [Yang, Jian; Guo, Lan-Ping] China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, Beijing 100700, Peoples R China; [Sun, Bing-Da] Chinese Acad Sci, Inst Microbiol, Beijing 100090, Peoples R China; [Qin, Jian-Chun] Jilin Univ, Coll Plant Sci, Changchun 130062, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiao-Yan,Tan, Xiang-Mei,Yu, Meng,et al. Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae)[J],2021,185.
APA	Zhang, Xiao-Yan.,Tan, Xiang-Mei.,Yu, Meng.,Yang, Jian.,Sun, Bing-Da.,...&Ding, Gang.(2021).Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae).PHYTOCHEMISTRY,185.
MLA	Zhang, Xiao-Yan,et al."Bioactive metabolites from the desert plant-associated endophytic fungus Chaetomium globosum (Chaetomiaceae)".PHYTOCHEMISTRY 185(2021).