干旱区生态环境知识资源中心(Arid): Inhalable Jojoba Oil Dry Nanoemulsion Powders for the Treatment of Lipopolysaccharide- or H2O2-Induced Acute Lung Injury

Arid

DOI	10.3390/pharmaceutics13040486
	Inhalable Jojoba Oil Dry Nanoemulsion Powders for the Treatment of Lipopolysaccharide- or H2O2-Induced Acute Lung Injury
	Zhang, Guoli; Xie, Fei; Sun, Yunbo; Yu, Xiang; Xiao, Zhimei; Fang, Rongzhen; Li, Jingfei; Li, Qian; Du, Lina; Jin, Yiguang
通讯作者	Du, LA ; Jin, YG (corresponding author), Anhui Med Univ, Graduates Dept, Hefei 230032, Peoples R China. ; Du, LA ; Jin, YG (corresponding author), Beijing Inst Radiat Med, Dept Pharmaceut Sci, 27 Taiping Rd, Beijing 100850, Peoples R China. ; Du, LA ; Jin, YG (corresponding author), Henan Univ, Pharmaceut Coll, Kaifeng 475004, Peoples R China.
来源期刊	PHARMACEUTICS
EISSN	1999-4923
出版年	2021
卷号	13 期号:4
英文摘要	Jojoba (Simmondsia chinensis (Link) C.K. Schneid) is a dioecious plant in desert and semi-desert areas, e.g., the Ismailia Desert in Egypt. Jojoba oil (JJBO) is a natural slight yellow oil with the functions of skin barrier repairing and wound healing, which is dermally applied as a traditional medication or cosmetic in the Middle East. The objective of this study was to prepare JJBO dry nanoemulsion powders (JNDs) and investigate their anti-acute lung injury effects. JJBO nanoemulsions (JNEs) were prepared and then lyophilized to JNDs and the properties and simulated lung deposition were measured. Rat acute lung injury (ALI) models were established after intratracheal (i.t.) administration of lipopolysaccharide (LPS) or hydrogen peroxide (H2O2). JNDs and dexamethasone (DXM) solutions were also i.t. administered to the rats. The pathological states of lung tissues were checked. Inflammatory and oxidative factors in the lung tissues were determined using ELISA methods. NF-kappa B p65 and caspase-3 were measured with a Western blotting method and an immunohistochemical method, respectively. JNDs had an appropriate mass median aerodynamic diameter (MMAD) of 4.17 mu m and a fine particle fraction (FPF) of 39.11%. JNDs showed higher anti-inflammatory effect on LPS-induced ALI than DXM with a decrease in total protein content and down-regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and NF-kappa B p65. JNDs also showed higher anti-inflammatory and anti-oxidation effect on H2O2-induced ALI than DXM with elimination of reactive oxygen species (ROS), increasing of superoxide dismutase (SOD), decrease in of lipid peroxide malondialdehyde (MDA) and glutathione (GSH), and inhibition of caspase-3 expression. Moreover, i.t. JNDs attenuated bleeding and infiltrations of the inflammatory cells in the two ALI models. JNDs are a promising natural oil-contained inhalable medication for the treatment of LPS- or H2O2-induced ALI.
英文关键词	jojoba oil acute lung injury nanoemulsion dry powder inhaler hydrogen peroxide lipopolysaccharide (LPS)
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000643505000001
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351305
作者单位	[Zhang, Guoli; Du, Lina; Jin, Yiguang] Anhui Med Univ, Graduates Dept, Hefei 230032, Peoples R China; [Zhang, Guoli; Sun, Yunbo; Yu, Xiang; Xiao, Zhimei; Fang, Rongzhen; Li, Jingfei; Li, Qian; Du, Lina; Jin, Yiguang] Beijing Inst Radiat Med, Dept Pharmaceut Sci, 27 Taiping Rd, Beijing 100850, Peoples R China; [Xie, Fei] Chinese Peoples Liberat Army Gen Hosp, Dept Pulm & Crit Care Med, Beijing 100853, Peoples R China; [Xiao, Zhimei; Fang, Rongzhen; Du, Lina; Jin, Yiguang] Henan Univ, Pharmaceut Coll, Kaifeng 475004, Peoples R China; [Li, Qian] Shandong Univ Tradit Chinese Med, Sch Med, Jinan 250355, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Guoli,Xie, Fei,Sun, Yunbo,et al. Inhalable Jojoba Oil Dry Nanoemulsion Powders for the Treatment of Lipopolysaccharide- or H2O2-Induced Acute Lung Injury[J],2021,13(4).
APA	Zhang, Guoli.,Xie, Fei.,Sun, Yunbo.,Yu, Xiang.,Xiao, Zhimei.,...&Jin, Yiguang.(2021).Inhalable Jojoba Oil Dry Nanoemulsion Powders for the Treatment of Lipopolysaccharide- or H2O2-Induced Acute Lung Injury.PHARMACEUTICS,13(4).
MLA	Zhang, Guoli,et al."Inhalable Jojoba Oil Dry Nanoemulsion Powders for the Treatment of Lipopolysaccharide- or H2O2-Induced Acute Lung Injury".PHARMACEUTICS 13.4(2021).