干旱区生态环境知识资源中心(Arid): Leptospira Seropositivity in Humans, Livestock and Wild Animals in a Semi-Arid Area of Tanzania

Arid

DOI	10.3390/pathogens10060696
	Leptospira Seropositivity in Humans, Livestock and Wild Animals in a Semi-Arid Area of Tanzania
	Mgode, Georgies F.; Mhamphi, Ginethon G.; Massawe, Apia W.; Machang'u, Robert S.
通讯作者	Mgode, GF (corresponding author), Sokoine Univ Agr, Pest Management Ctr, Africa Ctr Excellence Innovat Rodent Pest Managem, POB 3110, Morogoro, Tanzania.
来源期刊	PATHOGENS
EISSN	2076-0817
出版年	2021
卷号	10 期号:6
英文摘要	Background: Leptospirosis is among the major neglected zoonoses in developing countries. The prevalence of leptospirosis remains underestimated in many African countries because of limited diagnostic facilities. We studied Leptospira seropositivity prevalence in humans, sheep, goats and rodents in a semi-arid region of central Tanzania and compared findings with reports from humid tropical areas. The aims were to establish the disease burden in different settings; understand circulating Leptospira serovars and potential major reservoirs for establishing appropriate control measures. Methods: Humans, sheep, goats, rodents and shrews (insectivores) were sampled from Bahi district, a semi-arid area in central Tanzania. Samples were tested for leptospiral antibodies using microscopic agglutination test (MAT) consisting of Leptospira serovars mainly reported in Tanzania and reference strains. Findings were compared with previous data to determine the disease epidemiological patterns. Results and conclusion: Semi-arid area showed high Leptospira seropositivity prevalence in humans and domestic animals due to intensive human-animal interactions at scarce water points and by flash flooding which occur in the area. Rodent population in the semi-arid areas was relatively low due to flooding. Leptospira seropositivity in rodents was also slightly lower, and the rodents appeared to be prolific breeders, probably as a means to compensate for the lost population during extreme drought as well as during short spells of floods. Intensive human-animal interaction in the semi-arid areas especially, in water sources in valleys where human and animals often meet, likely increased the risk of leptospirosis transmission to rice farmers in the area. Goats and sheep which are kept around homesteads had higher leptospiral antibodies prevalence (62%), nearly double of the 38% reported in same species in humid tropical regions of Tanzania. Livestock, especially goats and sheep, could be the major source of leptospirosis transmission to humans. Vaccination of livestock with vaccines against local Leptospira strains should be encouraged, and rodent control emphasized, as part of a management strategy against leptospirosis. Public awareness of leptospirosis must also be raised and supported by availability of rapid test kits in clinics for preliminary testing of leptospirosis in people with fevers of unknown origin.
英文关键词	leptospirosis in Africa animal leptospirosis goats sheep rodent and shrew reservoirs leptospirosis burden microscopic agglutination test (MAT) water-borne infection zoonotic disease transmission human-animal interaction
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000666536300001
WOS关键词	TABLES
WOS类目	Microbiology
WOS研究方向	Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351288
作者单位	[Mgode, Georgies F.; Mhamphi, Ginethon G.; Massawe, Apia W.; Machang'u, Robert S.] Sokoine Univ Agr, Pest Management Ctr, Africa Ctr Excellence Innovat Rodent Pest Managem, POB 3110, Morogoro, Tanzania
推荐引用方式 GB/T 7714	Mgode, Georgies F.,Mhamphi, Ginethon G.,Massawe, Apia W.,et al. Leptospira Seropositivity in Humans, Livestock and Wild Animals in a Semi-Arid Area of Tanzania[J],2021,10(6).
APA	Mgode, Georgies F.,Mhamphi, Ginethon G.,Massawe, Apia W.,&Machang'u, Robert S..(2021).Leptospira Seropositivity in Humans, Livestock and Wild Animals in a Semi-Arid Area of Tanzania.PATHOGENS,10(6).
MLA	Mgode, Georgies F.,et al."Leptospira Seropositivity in Humans, Livestock and Wild Animals in a Semi-Arid Area of Tanzania".PATHOGENS 10.6(2021).