Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.3390/molecules26092831 |
| Phytochemical Profile and In Vitro Antioxidant, Antimicrobial, Vital Physiological Enzymes Inhibitory and Cytotoxic Effects of Artemisia jordanica Leaves Essential Oil from Palestine | |
| Jaradat, Nidal | |
| 通讯作者 | Jaradat, N (corresponding author), An Najah Natl Univ, Dept Pharm, Fac Med & Hlth Sci, POB 7, Nablus 00970, Palestine. |
| 来源期刊 | MOLECULES
 |
| EISSN | 1420-3049 |
| 出版年 | 2021 |
| 卷号 | 26期号:9 |
| 英文摘要 | Artemisia jordanica (AJ) is one of the folkloric medicinal plants and grows in the arid condition used by Palestinian Bedouins in the Al-Naqab desert for the treatment of diabetes and gastrointestinal infections. The current investigation aimed, for the first time, to characterize the (AJ) essential oil (EO) components and evaluate EO's antioxidant, anti-obesity, antidiabetic, antimicrobial, anti-inflammatory, and cytotoxic activities. The gas chromatography-mass spectrometer (GC-MS) technique was utilized to characterize the chemical ingredients of (AJ) EO, while validated biochemical approaches were utilized to evaluate the antioxidant, anti-obesity and antidiabetic. The microbicidal efficacy of (AJ) EO was measured utilizing the broth microdilution assay. Besides, the cytotoxic activity was estimated utilizing the (MTS) procedure. Finally, the anti-inflammatory activity was measured utilizing a COX inhibitory screening test kit. The analytical investigation revealed the presence of 19 molecules in the (AJ) EO. Oxygenated terpenoids, including bornyl acetate (63.40%) and endo-borneol (17.75%) presented as major components of the (AJ) EO. The EO exhibited potent antioxidant activity compared with Trolox, while it showed a weak anti-lipase effect compared with orlistat. In addition, the tested EO displayed a potent alpha-amylase suppressing effect compared with the positive control acarbose. Notably, the (AJ) EO exhibited strong alpha-glucosidase inhibitory potential compared with the positive control acarbose. The EO had has a cytotoxic effect against all the screened tumor cells. In fact, (AJ) EO showed potent antimicrobial properties. Besides, the EO inhibited the enzymes COX-1 and COX-2, compared with the anti-inflammatory drug ketoprofen. The (AJ) EO has strong antioxidant, antibacterial, antifungal, anti-alpha-amylase, anti-alpha-glucosidase, and COX inhibitory effects which could be a favorite candidate for the treatment of various neurodegenerative diseases caused by harmful free radicals, microbial resistance, diabetes, and inflammations. Further in-depth investigations are urgently crucial to explore the importance of such medicinal plants in pharmaceutical production. |
| 英文关键词 | Artemisia jordanica essential oil antioxidant anti-obesity antidiabetic antimicrobial anti-inflammatory cytotoxicity |
| 类型 | Article |
| 语种 | 英语 |
| 开放获取类型 | gold, Green Published |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000650692200001 |
| WOS关键词 | CHEMICAL-COMPOSITION ; BIOLOGICAL EVALUATION ; ALPHA-AMYLASE ; ANTIBACTERIAL ; DERIVATIVES ; L. ; CYCLOOXYGENASE-2 ; DRACUNCULUS ; ABSINTHIUM ; PLANTS |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/351169 |
| 作者单位 | [Jaradat, Nidal] An Najah Natl Univ, Dept Pharm, Fac Med & Hlth Sci, POB 7, Nablus 00970, Palestine |
| 推荐引用方式 GB/T 7714 | Jaradat, Nidal. Phytochemical Profile and In Vitro Antioxidant, Antimicrobial, Vital Physiological Enzymes Inhibitory and Cytotoxic Effects of Artemisia jordanica Leaves Essential Oil from Palestine[J],2021,26(9). |
| APA | Jaradat, Nidal.(2021).Phytochemical Profile and In Vitro Antioxidant, Antimicrobial, Vital Physiological Enzymes Inhibitory and Cytotoxic Effects of Artemisia jordanica Leaves Essential Oil from Palestine.MOLECULES,26(9). |
| MLA | Jaradat, Nidal."Phytochemical Profile and In Vitro Antioxidant, Antimicrobial, Vital Physiological Enzymes Inhibitory and Cytotoxic Effects of Artemisia jordanica Leaves Essential Oil from Palestine".MOLECULES 26.9(2021). |
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