干旱区生态环境知识资源中心(Arid): UHPLC-DAD Characterization of Origanum vulgare L. from Atacama Desert Andean Region and Antioxidant, Antibacterial and Enzyme Inhibition Activities

Arid

DOI	10.3390/molecules26072100
	UHPLC-DAD Characterization of Origanum vulgare L. from Atacama Desert Andean Region and Antioxidant, Antibacterial and Enzyme Inhibition Activities
	Parra, Claudio; Munoz, Patricio; Bustos, Luis; Parra, Felipe; Simirgiotis, Mario J.; Escobar, Hugo
通讯作者	Parra, C ; Escobar, H (corresponding author), Univ Tarapaca, Fac Ciencias Agron, Lab Quim Organ & Prod Nat, Av Gen Velasquez 1775, Arica 1000000, Chile.
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2021
卷号	26 期号:7
英文摘要	The Lamiaceae family is an important source of species among medicinal plants highly valued for their biological properties and numerous uses in folk medicine. Origanum is one of the main genera that belong to this family. The purpose of the study was to determine the phenolic composition of the Origanum vulgare extract and evaluate the antimicrobial, antioxidant, and inhibitory activities of this species that grows in the Andean region of the Atacama Desert. High-performance liquid chromatography was performed to determine the main phenols. Rosmarinic acid was identified as the predominant phenolic compound in this species (76.01 mg/100 g DW), followed by protocatechuic acid, which to our knowledge, no previous study reported similar concentrations in O. vulgare. The oregano extract exhibited a content of total phenolic (3948 mg GAE/100 g DW) and total flavonoid (593 mg QE/100 g DW) with a higher DPPH antioxidant activity (IC50 = 40.58 mu g/mL), compared to the same species grown under other conditions. Furthermore, it was found to inhibit alpha-glucosidase activity with an IC50 value (7.11 mg/mL) lower than acarbose (129.32 mg/mL). Pseudomonas syringae and Pantoea agglomerans (both MIC 0.313 mg/mL and MBC 1.25 mg/mL) were the bacteria most susceptible to oregano extract with the lowest concentration necessary to inhibit bacterial growth. These results open the door for the potential use of this plant to manage chronic diseases, and they expand the knowledge of the species cultivated in arid environmental conditions.
英文关键词	α -amylase α -glucosidase arid region bioactive compounds UHPLC-DAD oregano
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000638725100001
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351167
作者单位	[Parra, Claudio; Munoz, Patricio; Bustos, Luis; Parra, Felipe; Escobar, Hugo] Univ Tarapaca, Fac Ciencias Agron, Lab Quim Organ & Prod Nat, Av Gen Velasquez 1775, Arica 1000000, Chile; [Munoz, Patricio] Univ California Davis Chile, Life Sci Innovat Ctr, Santiago 7511303, Chile; [Simirgiotis, Mario J.] Univ Austral Chile, Fac Ciencias, Inst Farm, Valdivia 5110566, Chile
推荐引用方式 GB/T 7714	Parra, Claudio,Munoz, Patricio,Bustos, Luis,et al. UHPLC-DAD Characterization of Origanum vulgare L. from Atacama Desert Andean Region and Antioxidant, Antibacterial and Enzyme Inhibition Activities[J],2021,26(7).
APA	Parra, Claudio,Munoz, Patricio,Bustos, Luis,Parra, Felipe,Simirgiotis, Mario J.,&Escobar, Hugo.(2021).UHPLC-DAD Characterization of Origanum vulgare L. from Atacama Desert Andean Region and Antioxidant, Antibacterial and Enzyme Inhibition Activities.MOLECULES,26(7).
MLA	Parra, Claudio,et al."UHPLC-DAD Characterization of Origanum vulgare L. from Atacama Desert Andean Region and Antioxidant, Antibacterial and Enzyme Inhibition Activities".MOLECULES 26.7(2021).