干旱区生态环境知识资源中心(Arid): Efficacy of Yukmijihwang-tang on symptoms of Alzheimer disease A protocol for systematic review and meta-analysis

Arid

DOI	10.1097/MD.0000000000026363
	Efficacy of Yukmijihwang-tang on symptoms of Alzheimer disease A protocol for systematic review and meta-analysis
	Lee, Seunghee; Kwon, Do Hyung; Kim, Ju Yeon; Kim, Yunna; Cho, Seung-Hun; Jung, In Chul
通讯作者	Jung, IC (corresponding author), Daejeon Univ, Coll Korean Med, Dept Oriental Neuropsychiat, 62 Daehak Ro, Daejeon, South Korea.
来源期刊	MEDICINE
ISSN	0025-7974
EISSN	1536-5964
出版年	2021
卷号	100 期号:25
英文摘要	Background: Alzheimer disease (AD) is the most common cause of dementia, which may lead to severe memory loss and other cognitive disorders. Yukmijihwang-tang (YMJ), a type of Korean traditional herbal medicine, has been shown to be effective against neurodegenerative diseases. Although a meta-analysis on the efficacy of YMJ on AD exists, the study had some limitations, and there have been several newly published studies assessing the effect of YMJ. Therefore, the purpose of this study is to evaluate the efficacy and safety of YMJ as a treatment for AD through a meta-analysis. Methods: A systematic search of the following electronic databases will be conducted to identify eligible studies: MEDLINE (PubMed), Elsevier (EMBASE), The Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Korean Medical Database (KMBASE), Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Traditional Knowledge Portal, Citation Information by NII (CiNii), China National Knowledge Infrastructure (CNKI). All randomized controlled trials assessing the efficacy and safety of YMJ on the symptoms of AD will be included. Two independent reviewers will perform article retrieval, deduplication, data screening, data extraction, quality evaluation, and data analyses using RevMan version 5.4. The Cochrane risk of bias tool will be used to assess the quality of the trials. Results: This study will provide synthesis of the cognitive function measured with neuropsychological tests, behavioral and psychological symptoms of dementia (BPSD), and activities of daily living (ADL) measured using validated scales. The clinical effective rate and adverse events will also be analyzed to assess the efficacy and safety of YMJ for treating AD. Conclusion: This systematic review will provide evidence for the efficacy and safety of YMJ in AD. Ethics and dissemination: Ethical approval is not required because individual patient data will not be included in this study. The study findings will be disseminated through conference presentations.
英文关键词	Alzheimer disease dementia protocol systematic review Yukmijihwang-tang
类型	Review
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000664672200031
WOS关键词	TRADITIONAL HERBAL FORMULA
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351129
作者单位	[Lee, Seunghee] Daejeon Univ, Coll Korean Med, Daejeon, South Korea; [Kwon, Do Hyung; Kim, Yunna; Cho, Seung-Hun] Kyung Hee Univ, Dept Neuropsychiat, Coll Oriental Med, Seoul, South Korea; [Kwon, Do Hyung; Kim, Yunna; Cho, Seung-Hun; Jung, In Chul] WHO Collaborating Ctr, Res Grp Neurosci, East West Med Res Inst, Seoul, South Korea; [Kwon, Do Hyung; Kim, Yunna; Cho, Seung-Hun] Kyung Hee Univ, Grad Sch, Dept Clin Korean Med, Seoul, South Korea; [Kim, Ju Yeon; Jung, In Chul] Daejeon Univ, Coll Korean Med, Dept Oriental Neuropsychiat, 62 Daehak Ro, Daejeon, South Korea
推荐引用方式 GB/T 7714	Lee, Seunghee,Kwon, Do Hyung,Kim, Ju Yeon,et al. Efficacy of Yukmijihwang-tang on symptoms of Alzheimer disease A protocol for systematic review and meta-analysis[J],2021,100(25).
APA	Lee, Seunghee,Kwon, Do Hyung,Kim, Ju Yeon,Kim, Yunna,Cho, Seung-Hun,&Jung, In Chul.(2021).Efficacy of Yukmijihwang-tang on symptoms of Alzheimer disease A protocol for systematic review and meta-analysis.MEDICINE,100(25).
MLA	Lee, Seunghee,et al."Efficacy of Yukmijihwang-tang on symptoms of Alzheimer disease A protocol for systematic review and meta-analysis".MEDICINE 100.25(2021).