干旱区生态环境知识资源中心(Arid): Antimicrobial and Antibiofilm Activities of the Fungal Metabolites Isolated from the Marine Endophytes Epicoccum nigrum M13 and Alternaria alternata 13A

Arid

DOI	10.3390/md19040232
	Antimicrobial and Antibiofilm Activities of the Fungal Metabolites Isolated from the Marine Endophytes Epicoccum nigrum M13 and Alternaria alternata 13A
	Qader, M. Mallique; Hamed, Ahmed A.; Soldatou, Sylvia; Abdelraof, Mohamed; Elawady, Mohamed E.; Hassane, Ahmed S., I; Belbahri, Lassaad; Ebel, Rainer; Rateb, Mostafa E.
通讯作者	Rateb, ME (corresponding author), Univ West Scotland, Sch Comp Engn & Phys Sci, Paisley PA1 2BE, Renfrew, Scotland. ; Ebel, R (corresponding author), Univ Aberdeen, Marine Biodiscovery Ctr, Dept Chem, Aberdeen AB24 3UE, Scotland.
来源期刊	MARINE DRUGS
EISSN	1660-3397
出版年	2021
卷号	19 期号:4
英文摘要	Epicotripeptin (1), a new cyclic tripeptide along with four known cyclic dipeptides (2-5) and one acetamide derivative (6) were isolated from seagrass-associated endophytic fungus Epicoccum nigrum M13 recovered from the Red Sea. Additionally, two new compounds, cyclodidepsipeptide phragamide A (7) and trioxobutanamide derivative phragamide B (8), together with eight known compounds (9-16), were isolated from plant-derived endophyte Alternaria alternata 13A collected from a saline lake of Wadi El Natrun depression in the Sahara Desert. The structures of the isolated compounds were determined based on the 1D and 2D NMR spectroscopic data, HRESIMS data, and a comparison with the reported literature. The absolute configurations of 1 and 7 were established by advanced Marfey's and Mosher's ester analyses. The antimicrobial screening indicated that seven of the tested compounds exhibited considerable (MIC range of 2.5-5 mu g/mL) to moderate (10-20 mu g/mL) antibacterial effect against the tested Gram-positive strains and moderate to weak (10-30 mu g/mL) antibacterial effect against Gram-negative strains. Most of the compounds exhibited weak or no activity against the tested Gram-negative strains. On the other hand, four of the tested compounds showed considerable antibiofilm effects against biofilm forming Gram-positive and Gram-negative strains.
英文关键词	epicotripeptin phragamide Epicoccum Alternaria antimicrobial antibiofilm
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000643221900001
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/351117
作者单位	[Qader, M. Mallique; Hassane, Ahmed S., I; Rateb, Mostafa E.] Univ West Scotland, Sch Comp Engn & Phys Sci, Paisley PA1 2BE, Renfrew, Scotland; [Qader, M. Mallique] Natl Inst Fundamental Studies, Hantana Rd, Kandy 20000, Sri Lanka; [Hamed, Ahmed A.; Abdelraof, Mohamed] Natl Res Ctr, Microbial Chem Dept, 33 El Buhouth St, Giza 12622, Egypt; [Soldatou, Sylvia; Ebel, Rainer] Univ Aberdeen, Marine Biodiscovery Ctr, Dept Chem, Aberdeen AB24 3UE, Scotland; [Elawady, Mohamed E.] Natl Res Ctr, Microbial Biotechnol Dept, 33 El Buhouth St, Giza 12622, Egypt; [Hassane, Ahmed S., I] Aberdeen Royal Infirm, Foresterhill Hlth Campus, Aberdeen AB25 2ZN, Scotland; [Belbahri, Lassaad] Univ Neuchatel, Lab Soil Biol, CH-2000 Neuchatel, Switzerland
推荐引用方式 GB/T 7714	Qader, M. Mallique,Hamed, Ahmed A.,Soldatou, Sylvia,et al. Antimicrobial and Antibiofilm Activities of the Fungal Metabolites Isolated from the Marine Endophytes Epicoccum nigrum M13 and Alternaria alternata 13A[J],2021,19(4).
APA	Qader, M. Mallique.,Hamed, Ahmed A..,Soldatou, Sylvia.,Abdelraof, Mohamed.,Elawady, Mohamed E..,...&Rateb, Mostafa E..(2021).Antimicrobial and Antibiofilm Activities of the Fungal Metabolites Isolated from the Marine Endophytes Epicoccum nigrum M13 and Alternaria alternata 13A.MARINE DRUGS,19(4).
MLA	Qader, M. Mallique,et al."Antimicrobial and Antibiofilm Activities of the Fungal Metabolites Isolated from the Marine Endophytes Epicoccum nigrum M13 and Alternaria alternata 13A".MARINE DRUGS 19.4(2021).