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| DOI | 10.3390/life11040342 |
| The Genomic Code: DNA Pervasively Moulds Chromatin Structures Leaving no Room for Junk | |
| Bernardi, Giorgio | |
| 通讯作者 | Bernardi, G (corresponding author), Roma Tre Univ, Sci Dept, Viale Marconi 446, I-00146 Rome, Italy. ; Bernardi, G (corresponding author), Stn Zool Anton Dohrn, I-80121 Naples, Italy. |
| 来源期刊 | LIFE-BASEL
 |
| EISSN | 2075-1729 |
| 出版年 | 2021 |
| 卷号 | 11期号:4 |
| 英文摘要 | The chromatin of the human genome was analyzed at three DNA size levels. At the first, compartment level, two gene spaces were found many years ago: A GC-rich, gene-rich genome core and a GC-poor, gene-poor genome desert, the former corresponding to open chromatin centrally located in the interphase nucleus, the latter to closed chromatin located peripherally. This bimodality was later confirmed and extended by the discoveries (1) of LADs, the Lamina-Associated Domains, and InterLADs; (2) of two spatial compartments, A and B, identified on the basis of chromatin interactions; and (3) of forests and prairies characterized by high and low CpG islands densities. Chromatin compartments were shown to be associated with the compositionally different, flat and single- or multi-peak DNA structures of the two, GC-poor and GC-rich, super-families of isochores. At the second, sub-compartment, level, chromatin corresponds to flat isochores and to isochore loops (due to compositional DNA gradients) that are susceptible to extrusion. Finally, at the short-sequence level, two sets of sequences, GC-poor and GC-rich, define two different nucleosome spacings, a short one and a long one. In conclusion, chromatin structures are moulded according to a genomic code by DNA sequences that pervade the genome and leave no room for junk. |
| 英文关键词 | Genomic code chromatin structure junk DNA |
| 类型 | Review |
| 语种 | 英语 |
| 开放获取类型 | Green Published, gold |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000643211300001 |
| WOS关键词 | ISOCHORE STRUCTURE ; CPG ISLANDS ; INTERSPERSED REPEATS ; EUKARYOTIC GENOMES ; CHROMOSOMAL BANDS ; INTERPHASE NUCLEI ; 3-D STRUCTURE ; GENE-RICHEST ; GC CONTENT ; ORGANIZATION |
| WOS类目 | Biology ; Microbiology |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Microbiology |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/351103 |
| 作者单位 | [Bernardi, Giorgio] Roma Tre Univ, Sci Dept, Viale Marconi 446, I-00146 Rome, Italy; [Bernardi, Giorgio] Stn Zool Anton Dohrn, I-80121 Naples, Italy |
| 推荐引用方式 GB/T 7714 | Bernardi, Giorgio. The Genomic Code: DNA Pervasively Moulds Chromatin Structures Leaving no Room for Junk[J],2021,11(4). |
| APA | Bernardi, Giorgio.(2021).The Genomic Code: DNA Pervasively Moulds Chromatin Structures Leaving no Room for Junk.LIFE-BASEL,11(4). |
| MLA | Bernardi, Giorgio."The Genomic Code: DNA Pervasively Moulds Chromatin Structures Leaving no Room for Junk".LIFE-BASEL 11.4(2021). |
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