干旱区生态环境知识资源中心(Arid): On-line solid phase extraction-ultra-high performance liquid chromatography coupled to tandem mass spectrometry for the determination of N-nitrosodiethanolamine in baby shampoo

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DOI	10.1016/j.jpba.2021.114132
	On-line solid phase extraction-ultra-high performance liquid chromatography coupled to tandem mass spectrometry for the determination of N-nitrosodiethanolamine in baby shampoo
	Tada, Alyne; Rodrigues-Silva, Caio; Rath, Susanne
通讯作者	Rath, S (corresponding author), Univ Estadual Campinas, Inst Chem, Dept Analyt Chem, POB 6154, BR-13084971 Campinas, SP, Brazil.
来源期刊	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN	0731-7085
EISSN	1873-264X
出版年	2021
卷号	202
英文摘要	N-nitrosodiethanolamine (NDELA) is a carcinogenic contaminant of concern in the cosmetics industry. Contaminated raw material, degradation, reactions of ingredients of the formulation, or migration of packaging material can be responsible for the presence of NDELA in the final product. Liquid chromatography coupled to tandem mass spectrometry is the most widely accepted technique for the quantitation of NDELA in cosmetic products. Still, there is no consensus regarding the sample preparation procedure. The aim of this work was to evaluate the performance of two-dimensional liquid chromatography coupled with tandem mass spectrometry for the determination of NDELA in shampoo. In the first dimension an Oasis HLB SPE-column was used and in the second dimension a CSH C18 column. NDELA-d(8) was used as an internal standard. The 2D-LC parameters were optimized by a central composite multivariate design. However, before quantitation, a sample preparation step using solid-phase extraction was necessary to eliminate compounds present in the formulation, especially surfactants that were not compatible with the chromatographic columns. Moreover, the complex matrices and singular compositions of shampoo from different manufacturers required adjustments of the sample preparation procedure for each sample. The limit of quantitation of the method for the determination of NDELA in shampoo was in the range of 5-10 ng g(-1). The accuracy of the method at the LOQ (10 ng g(-1)) was 114 % and the inter-day precision of 15.3 % (n = 9). One sample out of 12 presented an NDELA concentration of 54 ng g(-1). (C) 2021 Elsevier B.V. All rights reserved.
英文关键词	N-nitrosodiethanolamine Shampoo Two-dimensional liquid chromatography Carcinogenic impurity
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000659231300011
WOS关键词	PERSONAL CARE PRODUCTS ; COSMETIC PRODUCTS ; NITROSAMINES ; CONTAMINATION ; VOLATILE ; NDELA
WOS类目	Chemistry, Analytical ; Pharmacology & Pharmacy
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350964
作者单位	[Rodrigues-Silva, Caio; Rath, Susanne] Univ Estadual Campinas, Inst Chem, Dept Analyt Chem, POB 6154, BR-13084971 Campinas, SP, Brazil; [Tada, Alyne] Brazilian Fed Inst, Brasilia, DF, Brazil
推荐引用方式 GB/T 7714	Tada, Alyne,Rodrigues-Silva, Caio,Rath, Susanne. On-line solid phase extraction-ultra-high performance liquid chromatography coupled to tandem mass spectrometry for the determination of N-nitrosodiethanolamine in baby shampoo[J],2021,202.
APA	Tada, Alyne,Rodrigues-Silva, Caio,&Rath, Susanne.(2021).On-line solid phase extraction-ultra-high performance liquid chromatography coupled to tandem mass spectrometry for the determination of N-nitrosodiethanolamine in baby shampoo.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,202.
MLA	Tada, Alyne,et al."On-line solid phase extraction-ultra-high performance liquid chromatography coupled to tandem mass spectrometry for the determination of N-nitrosodiethanolamine in baby shampoo".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 202(2021).