干旱区生态环境知识资源中心(Arid): Structurally Diverse Diterpenoids from the Roots of Salvia deserta Based on Nine Different Skeletal Types

Arid

DOI	10.1021/acs.jnatprod.0c01180
	Structurally Diverse Diterpenoids from the Roots of Salvia deserta Based on Nine Different Skeletal Types
	Kadir, Abdukriem; Zheng, Guijuan; Zheng, Xiaofeng; Jin, Pengfei; Maiwulanjiang, Maitinuer; Gao, Biao; Aisa, Haji Akber; Yao, Guangmin
通讯作者	Yao, GM (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China. ; Aisa, HA (corresponding author), Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China.
来源期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
EISSN	1520-6025
出版年	2021
卷号	84 期号:5 页码:1442-1452
英文摘要	Twenty-four diterpenoids (1-24), classified into nine diverse carbon skeletal types, 8-nor-7(8 -> 14),9(8 -> 7)-di-abeo-abietane (1, 2, and 13), 7(8 -> 14),9(8 -> 7)-di-abeo-abietane (3 and 4), 6-nor-6,7-seco-abietane (5 and 6), 6,7-seco-abietane (7 and 11), 9,10-seco-abietane (8), abietane (9, 10, and 14-21), 11(9 -> 8),20(10 -> 11)-di-abeo-abietane (12), 15(13 -> 12)-abeo-abietane (22 and 23), and 4,5-seco-20(10 -> 5)-abeo-abietane (24), respectively, were isolated from the roots of Salvia deserta. The structures of 10 new diterpenoids, named salviadesertins A-J (1-10), were elucidated by spectroscopic data interpretation, quantum-chemical calculations including calculated C-13 NMR-DP4+ analysis and electronic circular dichroism as well as X-ray crystallography analysis. The absolute configurations of compounds 1-3, 7, 14, and 22 were defined by single-crystal X-ray diffraction analysis. All the isolated diterpenoids 1-24 were evaluated for their cytotoxicity against five cancer cell lines, and 6-hydroxysalvinolone (14) showed micromolar potencies against MCF-7, A-549, SMMC-7721, and HL-60 cells, whereas the other diterpenoids were inactive (half-maximal inhibitory concentration greater than 10.0 mu M).
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000657373100003
WOS关键词	ABIETANE DITERPENOIDS ; CONSTITUENTS ; ANTIBACTERIAL ; BUDS
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350953
作者单位	[Kadir, Abdukriem; Zheng, Guijuan; Zheng, Xiaofeng; Jin, Pengfei; Gao, Biao; Yao, Guangmin] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China; [Kadir, Abdukriem; Maiwulanjiang, Maitinuer; Aisa, Haji Akber] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
推荐引用方式 GB/T 7714	Kadir, Abdukriem,Zheng, Guijuan,Zheng, Xiaofeng,et al. Structurally Diverse Diterpenoids from the Roots of Salvia deserta Based on Nine Different Skeletal Types[J],2021,84(5):1442-1452.
APA	Kadir, Abdukriem.,Zheng, Guijuan.,Zheng, Xiaofeng.,Jin, Pengfei.,Maiwulanjiang, Maitinuer.,...&Yao, Guangmin.(2021).Structurally Diverse Diterpenoids from the Roots of Salvia deserta Based on Nine Different Skeletal Types.JOURNAL OF NATURAL PRODUCTS,84(5),1442-1452.
MLA	Kadir, Abdukriem,et al."Structurally Diverse Diterpenoids from the Roots of Salvia deserta Based on Nine Different Skeletal Types".JOURNAL OF NATURAL PRODUCTS 84.5(2021):1442-1452.