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DOI	10.1016/j.ijid.2020.12.015
	Prevalence, genotypes and phylogenetic analysis of human papillomaviruses (HPV) in northeast Iran
	Sabet, Faezeh; Mosavat, Arman; Ghezeldasht, Sanaz Ahmadi; Basharkhah, Samira; Shamsian, Seyed Ali Akbar; Abbasnia, Shadi; Shamsian, Khosrow; Rezaee, Seyed Abdolrahim
通讯作者	Rezaee, SA (corresponding author), Mashhad Univ Med Sci, Immunol Res Ctr, Inflammat & Inflammatory Dis Div, Fac Med, Azadi Sq,Med Campus, Mashhad 9177948564, Razavi Khorasan, Iran.
来源期刊	INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
ISSN	1201-9712
EISSN	1878-3511
出版年	2021
卷号	103 页码:480-488
英文摘要	Objectives: Human papillomaviruses (HPV) are the main etiology of invasive cervical cancer. Together HPV and viral hepatitis account for the cause of 25% of cancers in developing countries. To evaluate the association between population movements and the spread of HPV, this study looked at prevalence, genotypes, and phylogenetic assessment of HPV in Great Khorasan, a pilgrimage-tourism province in northeast Iran. Methods: From March 2013 to July 2018, 567 samples were collected from three groups in Khorasan: Razavi and North Khorasan provinces (highly mobile population); South Khorasan province (conservative and desert); and diverse group (tourists). Results: HPV prevalence was 48.4% in Razavi and North Khorasan (first group); 19.9% in South Khorasan (second group); and 33.6% in the diverse group. The four most common HPV genotypes were HPV-6, 11, 51 and 16, in the first group; HPV-6, 11, 16 and 58 in the second group; and HPV-6, 11, 16 and 53/89 in the diverse group. The most frequent genotypes that are known as high risk for cervical cancer were HPV-51 in the first group, HPV-16 in the second group and the diverse group. Among low-risk genotypes, HPV-6, and HPV-11 were more frequent in all groups. DNA sequencing and phylogenetic analysis of 20 HPV-positive samples showed that the distributions of the HPV genotypes were HPV-6 (50%), 11 (10%), 67 (5%), 16 (15%), 31 (10%), 54 (5%), and 89 (5%). Conclusions: The findings show that areas associated with population movement should be frequently monitored for infectious diseases, while conservative and less populated areas have less risk for virus spread and endemicity. Health authorities should focus more on the establishment of HPV diagnostic facilities, screening, vaccination, and enhancement of public knowledge in these regions. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
英文关键词	Human papillomavirus (HPV) HPV genotypes Phylogenetic tree Prevalence Northeast Iran
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000616697100024
WOS类目	Infectious Diseases
WOS研究方向	Infectious Diseases
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350599
作者单位	[Sabet, Faezeh; Basharkhah, Samira; Abbasnia, Shadi; Rezaee, Seyed Abdolrahim] Mashhad Univ Med Sci, Immunol Res Ctr, Inflammat & Inflammatory Dis Div, Mashhad, Razavi Khorasan, Iran; [Mosavat, Arman; Ghezeldasht, Sanaz Ahmadi; Shamsian, Seyed Ali Akbar; Shamsian, Khosrow] Acad Ctr Educ Culture & Res ACECR, Blood Borne Infect Res Ctr, Mashhad, Razavi Khorasan, Iran; [Shamsian, Seyed Ali Akbar] Mashhad Univ Med Sci, Fac Med, Dept Mycol & Parasitol, Mashhad, Razavi Khorasan, Iran
推荐引用方式 GB/T 7714	Sabet, Faezeh,Mosavat, Arman,Ghezeldasht, Sanaz Ahmadi,et al. Prevalence, genotypes and phylogenetic analysis of human papillomaviruses (HPV) in northeast Iran[J],2021,103:480-488.
APA	Sabet, Faezeh.,Mosavat, Arman.,Ghezeldasht, Sanaz Ahmadi.,Basharkhah, Samira.,Shamsian, Seyed Ali Akbar.,...&Rezaee, Seyed Abdolrahim.(2021).Prevalence, genotypes and phylogenetic analysis of human papillomaviruses (HPV) in northeast Iran.INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,103,480-488.
MLA	Sabet, Faezeh,et al."Prevalence, genotypes and phylogenetic analysis of human papillomaviruses (HPV) in northeast Iran".INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 103(2021):480-488.