干旱区生态环境知识资源中心(Arid): In vitro anticoagulant effect of methanolic extracts of Artemisia herba-alba,alba, Achillea fragrantissima and Citrullus colocynthis grown in Saudi Arabia

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	In vitro anticoagulant effect of methanolic extracts of Artemisia herba-alba,alba, Achillea fragrantissima and Citrullus colocynthis grown in Saudi Arabia
	Alabdallat, Nessrin G.; Bin Dukhyil, Abdul Aziz A.
通讯作者	Alabdallat, NG (corresponding author), Majmaah Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Majmaah 11952, Saudi Arabia.
来源期刊	INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE
ISSN	0972-5938
EISSN	0975-1068
出版年	2021
卷号	20 期号:2 页码:344-350
英文摘要	Several medicinal plants are known to possess anticoagulant activity. This study proposed to evaluate the in vitro anticoagulant effect of methanol extracts of Citrullus colocynthis (fruits), Achillea fragrantissima (aerial parts) and Artemisia herba-alba (aerial parts) on normal human plasma. A total of 100 blood samples used in this study were taken from healthy volunteers at the Hematology laboratory of King Khalid Hospital, Al-Majmaah, Kingdom of Saudi Arabia from November 2018 to March 2019, using 3.2% sodium citrate tubes with a collection ratio of 9:1 blood to anticoagulant. PT, INR and PTT were used to assess the anticoagulant activity of these plants. The highest PT results were observed for 1000 mu g/mL methanol extract of C. colocynthis (33.7 +/- 3.4 s) followed by 1000 mu g/mL methanol extract of A. fragrantissima (28.2 +/- 2.6 s) and 1000 mu g/mL methanol extract of A. herba-alba (26.4 +/- 0.2 s). Moreover, the highest PTT values were observed for 250, 500 and 1000 mu g/mL A. fragrantissima (87.9 +/- 1.0, 97.9 +/- 5.1 and 112.5 +/- 1.1 s, respectively), 500 mu g/mL and 1000 mu g/mL C. colocynthis (65.1 +/- 1.0 and 106.4 +/- 0.4 s, respectively) and 1000 mu g/mL A. herba-alba (157.0 +/- 3.0 s). The anticoagulant effect of methanol extracts of A. herba-alba, A. fragrantissima, and C. colocynthis were evaluated using coagulation assays, in which prolonged clotting time of their methanol extracts was observed. These findings potentially justify the use of these plants in managing arterial and venous thrombotic disorders.
英文关键词	Artemisia herba-alba Achillea fragrantissima Citrullus colocynthis International normalized ratio Prothrombin time Partial thromboplastin time
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000659141200004
WOS关键词	MEDICINAL-PLANTS ; ESSENTIAL OIL ; ETHNOBOTANICAL SURVEY ; ANTIOXIDANT ACTIVITY ; DESERT PLANTS ; NEGEV
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350543
作者单位	[Alabdallat, Nessrin G.; Bin Dukhyil, Abdul Aziz A.] Majmaah Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Majmaah 11952, Saudi Arabia
推荐引用方式 GB/T 7714	Alabdallat, Nessrin G.,Bin Dukhyil, Abdul Aziz A.. In vitro anticoagulant effect of methanolic extracts of Artemisia herba-alba,alba, Achillea fragrantissima and Citrullus colocynthis grown in Saudi Arabia[J],2021,20(2):344-350.
APA	Alabdallat, Nessrin G.,&Bin Dukhyil, Abdul Aziz A..(2021).In vitro anticoagulant effect of methanolic extracts of Artemisia herba-alba,alba, Achillea fragrantissima and Citrullus colocynthis grown in Saudi Arabia.INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE,20(2),344-350.
MLA	Alabdallat, Nessrin G.,et al."In vitro anticoagulant effect of methanolic extracts of Artemisia herba-alba,alba, Achillea fragrantissima and Citrullus colocynthis grown in Saudi Arabia".INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE 20.2(2021):344-350.