干旱区生态环境知识资源中心(Arid): Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications

Arid

DOI	10.3389/fonc.2021.622752
	Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications
	Yang, Miner; Chen, Gaowen; Gao, Kunjie; Wang, Yifeng
通讯作者	Wang, YF (corresponding author), Southern Med Univ, Dept Gynecol, Obstet & Gynecol Ctr, Zhujiang Hosp, Guangzhou, Peoples R China.
来源期刊	FRONTIERS IN ONCOLOGY
ISSN	2234-943X
出版年	2021
卷号	11
英文摘要	Metabolic dysregulation in the tumor microenvironment has significant impact on immune infiltration and immune responses. However, interaction between immunity and metabolism in the ovarian microenvironment requires further exploration. We constructed an immunometabolism gene set and ovarian cancer cohort from The Cancer Genome Atlas (TCGA) and classified these into three immunometabolism subtypes. We explored the relationships between immune infiltration and metabolic reprogramming. Additionally, we built risk score and nomogram as prognostic signatures. Three distinctive immunometabolism subtypes were identified with therapeutic and prognostic implications. Subtype 1, the immune suppressive-glycan metabolism subtype, featured high levels of immunosuppressive cell infiltration and glycan metabolism activation; Subtype 2, the immune inflamed-amino acid metabolism subtype, showed abundant adaptive immune cell infiltration and amino acid metabolism activation; Subtype 3, the immune desert-endocrine subtype, was characterized by low immune cell infiltration and upregulation of hormone biosynthesis. Furthermore, we found that epinephrine biosynthesis displayed a significantly negative correlation with MHC molecules, which may result in defective antigen presentation. We proposed immunometabolism subtypes with prognostic implications and provided new perspectives for the ovarian cancer microenvironment.
英文关键词	ovarian cancer metabolism reprogramming epinephrine biosynthesis major histocompatibility complex immune microenvironment
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000634735200001
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350321
作者单位	[Yang, Miner; Chen, Gaowen; Gao, Kunjie; Wang, Yifeng] Southern Med Univ, Dept Gynecol, Obstet & Gynecol Ctr, Zhujiang Hosp, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Yang, Miner,Chen, Gaowen,Gao, Kunjie,et al. Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications[J],2021,11.
APA	Yang, Miner,Chen, Gaowen,Gao, Kunjie,&Wang, Yifeng.(2021).Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications.FRONTIERS IN ONCOLOGY,11.
MLA	Yang, Miner,et al."Tumor Immunometabolism Characterization in Ovarian Cancer With Prognostic and Therapeutic Implications".FRONTIERS IN ONCOLOGY 11(2021).