干旱区生态环境知识资源中心(Arid): The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy

Arid

DOI	10.3389/fimmu.2021.654877
	The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy
	Asiry, Saeed; Kim, Gina; Filippou, Panagiota S.; Sanchez, Luis Rivera; Entenberg, David; Marks, Douglas K.; Oktay, Maja H.; Karagiannis, George S.
通讯作者	Karagiannis, GS (corresponding author), Albert Einstein Coll Med, Dept Anat & Struct Biol, New York, NY 10461 USA. ; Karagiannis, GS (corresponding author), Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, New York, NY 10461 USA. ; Karagiannis, GS (corresponding author), Albert Einstein Coll Med, Integrated Imaging Program, New York, NY 10461 USA.
来源期刊	FRONTIERS IN IMMUNOLOGY
ISSN	1664-3224
出版年	2021
卷号	12
英文摘要	Although cancer immunotherapy has resulted in unpreceded survival benefits to subsets of oncology patients, accumulating evidence from preclinical animal models suggests that the immunosuppressive tumor microenvironment remains a detrimental factor limiting benefit for many patient subgroups. Recent efforts on lymphocyte-mediated immunotherapies are primarily focused on eliminating cancer foci at primary and metastatic sites, but few studies have investigated the impact of these therapies on the highly complex process of cancer cell dissemination. The metastatic cascade involves the directional streaming of invasive/migratory tumor cells toward specialized blood vessel intravasation gateways, called TMEM doorways, to the peripheral circulation. Importantly, this process occurs under the auspices of a specialized tumor microenvironment, herewith referred to as Dissemination Trajectory, which is supported by an ample array of tumor-associated macrophages (TAMs), skewed towards an M2-like polarization spectrum, and which is also vital for providing microenvironmental cues for cancer cell invasion, migration and stemness. Based on pre-existing evidence from preclinical animal models, this article outlines the hypothesis that dissemination trajectories do not only support the metastatic cascade, but also embody immunosuppressive niches, capable of providing transient and localized immunosubversion cues to the migratory/invasive cancer cell subpopulation while in the act of departing from a primary tumor. So long as these dissemination trajectories function as immune deserts, the migratory tumor cell subpopulation remains efficient in evading immunological destruction and seeding metastatic sites, despite administration of cancer immunotherapy and/or other cytotoxic treatments. A deeper understanding of the molecular and cellular composition, as well as the signaling circuitries governing the function of these dissemination trajectories will further our overall understanding on TAM-mediated immunosuppression and will be paramount for the development of new therapeutic strategies for the advancement of optimal cancer chemotherapies, immunotherapies, and targeted therapies.
英文关键词	cancer immunotherapy tumor microenvironment endothelial anergy lymphocyte exclusion lymphocyte exhaustion metastasis macrophages T cells
类型	Review
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000644422600001
WOS类目	Immunology
WOS研究方向	Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350304
作者单位	[Asiry, Saeed; Oktay, Maja H.] Albert Einstein Coll Med, Dept Pathol, Montefiore Med Ctr, New York, NY USA; [Kim, Gina] Albert Einstein Coll Med, Dept Surg, Montefiore Med Ctr, New York, NY USA; [Filippou, Panagiota S.] Teesside Univ, Sch Hlth & Life Sci, Middlesbrough, Cleveland, England; [Filippou, Panagiota S.] Teesside Univ, Natl Horizons Ctr, Darlington, Durham, England; [Sanchez, Luis Rivera; Entenberg, David; Oktay, Maja H.; Karagiannis, George S.] Albert Einstein Coll Med, Dept Anat & Struct Biol, New York, NY 10461 USA; [Entenberg, David; Oktay, Maja H.; Karagiannis, George S.] Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, New York, NY 10461 USA; [Entenberg, David; Oktay, Maja H.; Karagiannis, George S.] Albert Einstein Coll Med, Integrated Imaging Program, New York, NY 10461 USA; [Marks, Douglas K.] NYU, Dept Med, Long Isl Sch Med, Mineola, NY USA
推荐引用方式 GB/T 7714	Asiry, Saeed,Kim, Gina,Filippou, Panagiota S.,et al. The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy[J],2021,12.
APA	Asiry, Saeed.,Kim, Gina.,Filippou, Panagiota S..,Sanchez, Luis Rivera.,Entenberg, David.,...&Karagiannis, George S..(2021).The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy.FRONTIERS IN IMMUNOLOGY,12.
MLA	Asiry, Saeed,et al."The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy".FRONTIERS IN IMMUNOLOGY 12(2021).