干旱区生态环境知识资源中心(Arid): Hydrazine-Containing Heterocycle Cytochalasan Derivatives From Hydrazinolysis of Extracts of a Desert Soil-Derived Fungus Chaetomium madrasense 375

Arid

DOI	10.3389/fchem.2021.620589
	Hydrazine-Containing Heterocycle Cytochalasan Derivatives From Hydrazinolysis of Extracts of a Desert Soil-Derived Fungus Chaetomium madrasense 375
	Guo, Qingfeng; Chen, Jinhua; Ren, Yuwei; Yin, Zhenhua; Zhang, Juanjuan; Yang, Baocheng; Wang, Xuewei; Yin, Wenbing; Zhang, Wancun; Ding, Gang; Chen, Lin
通讯作者	Chen, L (corresponding author), Huanghe Sci & Technol Coll, Comprehens Utilizat Edible & Med Plant Resources, Zhengzhou Key Lab Med Resources Res, Zhengzhou Key Lab Synthet Biol Nat Prod, Zhengzhou, Peoples R China. ; Zhang, WC (corresponding author), Zhengzhou Univ, Childrens Hosp, Henan Key Lab Childrens Genet & Metab Dis, Zhengzhou, Peoples R China. ; Ding, G (corresponding author), Chinese Acad Med Sci & Union Med Coll, Inst Med Plant Dev, Beijing, Peoples R China.
来源期刊	FRONTIERS IN CHEMISTRY
ISSN	2296-2646
出版年	2021
卷号	9
英文摘要	Diversity-enhanced extracts is an effective method of producing chemical libraries for the purpose of drug discovery. Three rare new cytochalasan derivative chaetoglobosins B-1-B-3 (1-3) were obtained from chemically engineered crude broth extracts of Chaetomium madrasense 375 prepared by reacting with hydrazine monohydrate and four known metabolite chaetoglobosins (4-7) were also identified from the fungus. The structures were identified by NMR and MS analysis and electronic circular dichroism simulation. In addition, the antiproliferative activities of these compounds were also evaluated, and the drug-resistant activities of cytochalasans were evaluated for the first time. Compound 6 possessed potent activity against four human cancer cells (A549, HCC827, SW620, and MDA-MB-231), and two drug-resistant HCC827 cells (Gefitinib-resistant, Osimertinib-resistant) compared with the positive controls.
英文关键词	diversity-enhanced cytochalasans antiproliferative activity chaetomium madrasense hydrazinolysis
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000647028000001
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350271
作者单位	[Guo, Qingfeng; Ren, Yuwei; Yin, Zhenhua; Zhang, Juanjuan; Yang, Baocheng; Chen, Lin] Huanghe Sci & Technol Coll, Comprehens Utilizat Edible & Med Plant Resources, Zhengzhou Key Lab Med Resources Res, Zhengzhou Key Lab Synthet Biol Nat Prod, Zhengzhou, Peoples R China; [Chen, Jinhua] Zhengzhou Univ, Henan Canc Hosp, Affiliated Canc Hosp, Dept Pharm, Zhengzhou, Peoples R China; [Wang, Xuewei; Yin, Wenbing] Chinese Acad Sci, State Key Lab Mycol, Inst Microbiol, Beijing, Peoples R China; [Zhang, Wancun] Zhengzhou Univ, Childrens Hosp, Henan Key Lab Childrens Genet & Metab Dis, Zhengzhou, Peoples R China; [Ding, Gang] Chinese Acad Med Sci & Union Med Coll, Inst Med Plant Dev, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Guo, Qingfeng,Chen, Jinhua,Ren, Yuwei,et al. Hydrazine-Containing Heterocycle Cytochalasan Derivatives From Hydrazinolysis of Extracts of a Desert Soil-Derived Fungus Chaetomium madrasense 375[J],2021,9.
APA	Guo, Qingfeng.,Chen, Jinhua.,Ren, Yuwei.,Yin, Zhenhua.,Zhang, Juanjuan.,...&Chen, Lin.(2021).Hydrazine-Containing Heterocycle Cytochalasan Derivatives From Hydrazinolysis of Extracts of a Desert Soil-Derived Fungus Chaetomium madrasense 375.FRONTIERS IN CHEMISTRY,9.
MLA	Guo, Qingfeng,et al."Hydrazine-Containing Heterocycle Cytochalasan Derivatives From Hydrazinolysis of Extracts of a Desert Soil-Derived Fungus Chaetomium madrasense 375".FRONTIERS IN CHEMISTRY 9(2021).