干旱区生态环境知识资源中心(Arid): Simultaneous enantioselective analysis of illicit drugs in wastewater and surface water by chiral LC-MS/MS: A pilot study on a wastewater treatment plant and its receiving river

Arid

DOI	10.1016/j.envpol.2021.116424
	Simultaneous enantioselective analysis of illicit drugs in wastewater and surface water by chiral LC-MS/MS: A pilot study on a wastewater treatment plant and its receiving river
	Wang, Weimin; Guo, Changsheng; Chen, Like; Qiu, Ziwen; Yin, Xingxing; Xu, Jian
通讯作者	Xu, J (corresponding author), Chinese Res Inst Environm Sci, State Environm Protect Key Lab Ecol Effect & Risk, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China.
来源期刊	ENVIRONMENTAL POLLUTION
ISSN	0269-7491
EISSN	1873-6424
出版年	2021
卷号	273
英文摘要	An enantioselective method for quantifying amphetamine-type chiral illicit drugs (CIDs) in wastewater and surface water was developed, validated, and applied to samples from a wastewater treatment plant (WWTP) and its effluent-receiving river in Beijing, China. Water samples were subjected to solid-phase extraction (SPE) and then quantified via liquid chromatography-tandem mass spectrometry. The enantioseparation of CIDs was performed with a CHIRALPAK CBH column. Chromatographic parameters, including mobile phase composition and flow rates, were tested to identify the satisfactory enantiomeric resolution. The SPE method was optimized by evaluating variables, including SPE cartridge types, extraction solvents, and solvent volumes. The Oasis HLB sorbent showed good performance with recoveries exceeding 60% and matrix effects ranging from -19.6% to 26.6% for most target enantiomers, except for norephedrine (NE), in three different aquatic matrixes. The established method was superior to previously reported methods and had a low limit of detection, low limit of quantification, and short runtime (<45 min). The repeatability and reproducibility of the method reached 19.1% and 17.8%, respectively. The method was successfully utilized to monitor the daily variations in CIDs in the influent, effluent, and effluent-receiving river of a WWTP in Beijing over 1 week. The common occurrence of 1 R,2 S-(-)-ephedrine (1 R,2 S-(-)-EPH), 1 S,2 S-(+)-pseudoephedrine (1 S,2 S-(+)-PEPH), R(-)-methamphetamine (METH), and S-(+)-METH in wastewater samples was observed. Ephedrines (1 R,2 S-(-)-EPH and 1 S,2 S-(+)-PEPH) were the most abundant CIDs in the influent, effluent, upstream, and downstream samples with concentrations of 725.8 +/- 181.2 ng/L, 22.9 +/- 4.9 ng/L, 12.96 +/- 0.79 ng/L, and 11.6 +/- 6.7 ng/L, respectively. METH was detectable in most water samples and was present in excess in S-enantiomer form in the influent and in R-enantiomer form in the effluent and surface water. R(-)-MDMA was detected at a concentration of up to 2.4 ng/L in the influent. The metabolites norketamine (NK), amphetamine(AMP), MDA, and NE were not detected in water samples given the low concentration of their parent drugs. (C) 2021 Elsevier Ltd. All rights reserved.
英文关键词	Chiral illicit drugs Wastewater Surface water Enantioseparation LC-MS/MS
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000625376600021
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
来源机构	北京师范大学
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/350139
作者单位	[Wang, Weimin; Guo, Changsheng; Chen, Like; Qiu, Ziwen; Yin, Xingxing; Xu, Jian] Chinese Res Inst Environm Sci, State Environm Protect Key Lab Ecol Effect & Risk, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China; [Wang, Weimin; Yin, Xingxing; Xu, Jian] Beijing Normal Univ, Coll Water Sci, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Wang, Weimin,Guo, Changsheng,Chen, Like,et al. Simultaneous enantioselective analysis of illicit drugs in wastewater and surface water by chiral LC-MS/MS: A pilot study on a wastewater treatment plant and its receiving river[J]. 北京师范大学,2021,273.
APA	Wang, Weimin,Guo, Changsheng,Chen, Like,Qiu, Ziwen,Yin, Xingxing,&Xu, Jian.(2021).Simultaneous enantioselective analysis of illicit drugs in wastewater and surface water by chiral LC-MS/MS: A pilot study on a wastewater treatment plant and its receiving river.ENVIRONMENTAL POLLUTION,273.
MLA	Wang, Weimin,et al."Simultaneous enantioselective analysis of illicit drugs in wastewater and surface water by chiral LC-MS/MS: A pilot study on a wastewater treatment plant and its receiving river".ENVIRONMENTAL POLLUTION 273(2021).