干旱区生态环境知识资源中心(Arid): Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation

Arid

DOI	10.1038/s42003-021-02327-3
	Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation
	Alvira-Iraizoz, Fernando; Gillard, Benjamin T.; Lin, Panjiao; Paterson, Alex; Pauza, Audrys G.; Ali, Mahmoud A.; Alabsi, Ammar H.; Burger, Pamela A.; Hamadi, Naserddine; Adem, Abdu; Murphy, David; Greenwood, Michael P.
通讯作者	Alvira-Iraizoz, F (corresponding author), Univ Bristol, Bristol Med Sch Translat Hlth Sci, Mol Neuroendocrinol Res Grp, Bristol, Avon, England. ; Adem, A (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Al Ain, U Arab Emirates. ; Adem, A (corresponding author), Khalifa Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Abu Dhabi, U Arab Emirates.
来源期刊	COMMUNICATIONS BIOLOGY
EISSN	2399-3642
出版年	2021
卷号	4 期号:1
英文摘要	The Arabian camel (Camelus dromedarius) is the most important livestock animal in arid and semi-arid regions and provides basic necessities to millions of people. In the current context of climate change, there is renewed interest in the mechanisms that enable camelids to survive in arid conditions. Recent investigations described genomic signatures revealing evolutionary adaptations to desert environments. We now present a comprehensive catalogue of the transcriptomes and proteomes of the dromedary kidney and describe how gene expression is modulated as a consequence of chronic dehydration and acute rehydration. Our analyses suggested an enrichment of the cholesterol biosynthetic process and an overrepresentation of categories related to ion transport. Thus, we further validated differentially expressed genes with known roles in water conservation which are affected by changes in cholesterol levels. Our datasets suggest that suppression of cholesterol biosynthesis may facilitate water retention in the kidney by indirectly facilitating the AQP2-mediated water reabsorption. Fernando Alvira-Iraizoz and Benjamin T. Gillard et al. comprehensively catalogue the kidney transcriptome and proteome of dromedary camels in response to chronic dehydration stress and subsequent acute rehydration. Their results suggest that the suppression of the cholesterol biosynthesis may facilitate water retention in the dromedary camel kidney, providing further insight into how these animals survive in arid conditions.
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000668713800005
WOS关键词	MEDULLARY THICKNESS ; COLLECTING DUCT ; GENE-EXPRESSION ; RENAL-FUNCTION ; INNER MEDULLA ; BLOOD-CELLS ; DNA-DAMAGE ; BODY-SIZE ; RNA-SEQ ; RAT
WOS类目	Biology ; Multidisciplinary Sciences
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/349871
作者单位	[Alvira-Iraizoz, Fernando; Gillard, Benjamin T.; Lin, Panjiao; Paterson, Alex; Pauza, Audrys G.; Murphy, David; Greenwood, Michael P.] Univ Bristol, Bristol Med Sch Translat Hlth Sci, Mol Neuroendocrinol Res Grp, Bristol, Avon, England; [Ali, Mahmoud A.; Adem, Abdu] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Al Ain, U Arab Emirates; [Alabsi, Ammar H.] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia; [Burger, Pamela A.] Vetmeduni Vienna, Res Inst Wildlife Ecol, Dept Interdisciplinary Life Sci, Vienna, Austria; [Hamadi, Naserddine] Zayed Univ, Coll Nat & Hlth Sci, Dept Life & Environm Sci, Abu Dhabi, U Arab Emirates; [Adem, Abdu] Khalifa Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Abu Dhabi, U Arab Emirates
推荐引用方式 GB/T 7714	Alvira-Iraizoz, Fernando,Gillard, Benjamin T.,Lin, Panjiao,et al. Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation[J],2021,4(1).
APA	Alvira-Iraizoz, Fernando.,Gillard, Benjamin T..,Lin, Panjiao.,Paterson, Alex.,Pauza, Audrys G..,...&Greenwood, Michael P..(2021).Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation.COMMUNICATIONS BIOLOGY,4(1).
MLA	Alvira-Iraizoz, Fernando,et al."Multiomic analysis of the Arabian camel (Camelus dromedarius) kidney reveals a role for cholesterol in water conservation".COMMUNICATIONS BIOLOGY 4.1(2021).