干旱区生态环境知识资源中心(Arid): Biodiversity, Bioactivity, and Metabolites of High Desert Derived Oregonian Soil Bacteria

Arid

DOI	10.1002/cbdv.202100046
	Biodiversity, Bioactivity, and Metabolites of High Desert Derived Oregonian Soil Bacteria
	Zhu, Chenxi; Lew, Cassandra, I; Neuhaus, George F.; Adpressa, Donovon A.; Zakharov, Lev N.; Kaweesa, Elizabeth N.; Plitzko, Birte; Loesgen, Sandra
通讯作者	Loesgen, S (corresponding author), Oregon State Univ, Dept Chem, Gilbert Hall 153, Corvallis, OR 97331 USA. ; Loesgen, S (corresponding author), Univ Florida, Dept Chem, Whitney Lab Marine Biosci, St Augustine, FL 32080 USA.
来源期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
EISSN	1612-1880
出版年	2021
卷号	18 期号:4
英文摘要	From arid, high desert soil samples collected near Bend, Oregon, 19 unique bacteria were isolated. Each strain was identified by 16S rRNA gene sequencing, and their organic extracts were tested for antibacterial and antiproliferative activities. Noteworthy, six extracts (30 %) exhibited strong inhibition resulting in less than 50 % cell proliferation in more than one cancer cell model, tested at 10 mu g/mL. Principal component analysis (PCA) of LC/MS data revealed drastic differences in the metabolic profiles found in the organic extracts of these soil bacteria. In total, fourteen potent antibacterial and/or cytotoxic metabolites were isolated via bioactivity-guided fractionation, including two new natural products: a pyrazinone containing tetrapeptide and 7-methoxy-2,3-dimethyl-4H-chromen-4-one, as well as twelve known compounds: furanonaphthoquinone I, bafilomycin C1 and D, FD-594, oligomycin A, chloramphenicol, MY12-62A, rac-sclerone, isosclerone, tunicamycin VII, tunicamycin VIII, and (6S,16S)-anthrabenzoxocinone 1.264-C.
英文关键词	natural products soil bacteria actinomyces antibiotics cytotoxicity
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000631874700001
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/349834
作者单位	[Zhu, Chenxi; Lew, Cassandra, I; Neuhaus, George F.; Adpressa, Donovon A.; Zakharov, Lev N.; Kaweesa, Elizabeth N.; Plitzko, Birte; Loesgen, Sandra] Oregon State Univ, Dept Chem, Gilbert Hall 153, Corvallis, OR 97331 USA; [Zhu, Chenxi; Kaweesa, Elizabeth N.; Loesgen, Sandra] Univ Florida, Dept Chem, Whitney Lab Marine Biosci, St Augustine, FL 32080 USA
推荐引用方式 GB/T 7714	Zhu, Chenxi,Lew, Cassandra, I,Neuhaus, George F.,et al. Biodiversity, Bioactivity, and Metabolites of High Desert Derived Oregonian Soil Bacteria[J],2021,18(4).
APA	Zhu, Chenxi.,Lew, Cassandra, I.,Neuhaus, George F..,Adpressa, Donovon A..,Zakharov, Lev N..,...&Loesgen, Sandra.(2021).Biodiversity, Bioactivity, and Metabolites of High Desert Derived Oregonian Soil Bacteria.CHEMISTRY & BIODIVERSITY,18(4).
MLA	Zhu, Chenxi,et al."Biodiversity, Bioactivity, and Metabolites of High Desert Derived Oregonian Soil Bacteria".CHEMISTRY & BIODIVERSITY 18.4(2021).