干旱区生态环境知识资源中心(Arid): Modeling genome-wide by environment interactions through omnigenic interactome networks

Arid

DOI	10.1016/j.celrep.2021.109114
	Modeling genome-wide by environment interactions through omnigenic interactome networks
	Wang, Haojie; Ye, Meixia; Fu, Yaru; Dong, Ang; Zhang, Miaomiao; Feng, Li; Zhu, Xuli; Bo, Wenhao; Jiang, Libo; Griffin, Christopher H.; Liang, Dan; Wu, Rongling
通讯作者	Wu, RL (corresponding author), Beijing Forestry Univ, Coll Biol Sci & Technol, Beijing Adv Innovat Ctr Tree Breeding Mol Design, Beijing 100083, Peoples R China. ; Wu, RL (corresponding author), Penn State Univ, Ctr Stat Genet, Dept Publ Hlth Sci, Hershey, PA 17033 USA. ; Wu, RL (corresponding author), Penn State Univ, Ctr Stat Genet, Dept Stat, Hershey, PA 17033 USA.
来源期刊	CELL REPORTS
ISSN	2211-1247
出版年	2021
卷号	35 期号:6
英文摘要	How genes interact with the environment to shape phenotypic variation and evolution is a fundamental question intriguing to biologists from various fields. Existing linear models built on single genes are inadequate to reveal the complexity of genotype-environment (G-E) interactions. Here, we develop a conceptual model for mechanistically dissecting G-E interplay by integrating previously disconnected theories and methods. Under this integration, evolutionary game theory, developmental modularity theory, and a variable selection method allow us to reconstruct environment-induced, maximally informative, sparse, and casual multilayer genetic networks. We design and conduct two mapping experiments by using a desert-adapted tree species to validate the biological application of the model proposed. The model identifies previously uncharacterized molecular mechanisms that mediate trees' response to saline stress. Our model provides a tool to comprehend the genetic architecture of trait variation and evolution and trace the information flow of each gene toward phenotypes within omnigenic networks.
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000649197800023
WOS关键词	GENETIC ARCHITECTURE ; ADAPTIVE LASSO ; EXPRESSION ; EVOLUTION ; PERSPECTIVE ; PLASTICITY ; FRAMEWORK ; TOOLBOX ; TRAITS ; SYSTEM
WOS类目	Cell Biology
WOS研究方向	Cell Biology
来源机构	北京林业大学
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/349821
作者单位	[Wang, Haojie; Ye, Meixia; Fu, Yaru; Dong, Ang; Zhang, Miaomiao; Feng, Li; Zhu, Xuli; Bo, Wenhao; Jiang, Libo; Liang, Dan; Wu, Rongling] Beijing Forestry Univ, Coll Biol Sci & Technol, Beijing Adv Innovat Ctr Tree Breeding Mol Design, Beijing 100083, Peoples R China; [Griffin, Christopher H.] Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA; [Wu, Rongling] Penn State Univ, Ctr Stat Genet, Dept Publ Hlth Sci, Hershey, PA 17033 USA; [Wu, Rongling] Penn State Univ, Ctr Stat Genet, Dept Stat, Hershey, PA 17033 USA
推荐引用方式 GB/T 7714	Wang, Haojie,Ye, Meixia,Fu, Yaru,et al. Modeling genome-wide by environment interactions through omnigenic interactome networks[J]. 北京林业大学,2021,35(6).
APA	Wang, Haojie.,Ye, Meixia.,Fu, Yaru.,Dong, Ang.,Zhang, Miaomiao.,...&Wu, Rongling.(2021).Modeling genome-wide by environment interactions through omnigenic interactome networks.CELL REPORTS,35(6).
MLA	Wang, Haojie,et al."Modeling genome-wide by environment interactions through omnigenic interactome networks".CELL REPORTS 35.6(2021).