Arid
DOI10.1007/s00449-020-02507-1
Isolation, identification and bioactivity analysis of an endophytic fungus isolated from Aloe vera collected from Asir desert, Saudi Arabia
Ameen, Fuad; Stephenson, Steven L.; AlNadhari, Saleh; Yassin, Mohamed A.
通讯作者Ameen, F (corresponding author), King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia.
来源期刊BIOPROCESS AND BIOSYSTEMS ENGINEERING
ISSN1615-7591
EISSN1615-7605
出版年2021
卷号44期号:6页码:1063-1070
英文摘要Endophytic fungi isolated from desert plants are among the less known organisms with potentially valuable applications. The bioactivities of an endophytic fungus isolated from Aloe vera, a plant found in central regions of Asir desert, Saudi Arabia. Based on primary phytochemical screening, an efficient isolate was selected and identified according to the sequence analysis of the internal spacer regions ITS1, ITS4 and the 5.8S region as Preussia africana belonging to the family Sporormiaceae. The crude extract of this fungus was evaluated for its bioactivities. Under static conditions, the crude extract at a concentration of 500 mu g/mL had a strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging rate of 87%, whereas a higher concentration (100 mu g/mL) had an astounding wound healing effect (42.6% at 48 h) when compared to positive control. Moreover, the crude extract with a concentration of 50 mu g/mL was active against almost all cancer cell lines such as HeLa (cervical cancer), Hep G2 (liver cancer), MCF-7 (breast cancer), A549 (lung cancer), LN-229 (glioblastoma), A-431 (skin cancer), and kidney cell line (HEK 293T). The results suggest that the endophytic fungus P. africana from A. vera has wide therapeutic applications against severe disease conditions.
英文关键词Endophytic fungi Preussia africana Aloe vera Bioactivity DPPH Anticancer activity
类型Article
语种英语
收录类别SCI-E
WOS记录号WOS:000611439100001
WOS类目Biotechnology & Applied Microbiology ; Engineering, Chemical
WOS研究方向Biotechnology & Applied Microbiology ; Engineering
来源机构King Saud University
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/349718
作者单位[Ameen, Fuad; Yassin, Mohamed A.] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia; [Stephenson, Steven L.] Univ Arkansas, Dept Biol Sci, Fayetteville, AR 72701 USA; [AlNadhari, Saleh] King Saud Univ, Coll Agr, Dept Plant Protect, Riyadh, Saudi Arabia; [Yassin, Mohamed A.] Plant Pathol Res Inst, Agr Res Ctr, Giza, Egypt
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GB/T 7714
Ameen, Fuad,Stephenson, Steven L.,AlNadhari, Saleh,et al. Isolation, identification and bioactivity analysis of an endophytic fungus isolated from Aloe vera collected from Asir desert, Saudi Arabia[J]. King Saud University,2021,44(6):1063-1070.
APA Ameen, Fuad,Stephenson, Steven L.,AlNadhari, Saleh,&Yassin, Mohamed A..(2021).Isolation, identification and bioactivity analysis of an endophytic fungus isolated from Aloe vera collected from Asir desert, Saudi Arabia.BIOPROCESS AND BIOSYSTEMS ENGINEERING,44(6),1063-1070.
MLA Ameen, Fuad,et al."Isolation, identification and bioactivity analysis of an endophytic fungus isolated from Aloe vera collected from Asir desert, Saudi Arabia".BIOPROCESS AND BIOSYSTEMS ENGINEERING 44.6(2021):1063-1070.
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