干旱区生态环境知识资源中心(Arid): Optimizing Chiral Selectivity in Practical Life-Detection Instruments

Arid

DOI	10.1089/ast.2020.2381
	Optimizing Chiral Selectivity in Practical Life-Detection Instruments
	Zhang, Ling; Zeng, Fanjiang; McKay, Christopher P.; Navarro-Gonzalez, Rafael; Sun, Henry J.
通讯作者	Sun, HJ (corresponding author), 755 E Flamingo Rd, Las Vegas, NV 89119 USA.
来源期刊	ASTROBIOLOGY
ISSN	1531-1074
EISSN	1557-8070
出版年	2021
卷号	21 期号:5 页码:505-510
英文摘要	Preferential uptake of either levorotatory (L) or dextrorotatory (D) enantiomer of a chiral molecule is a potential planetary life-detection method. On Earth, bacteria, as a rule, metabolize D-sugars and L-amino acids. Here, we use growth experiments to identify exceptions to the rule and their potential impact on the method's reliability. Our experiments involve six strains of Bacillus and collective uptake of the sugars glucose and arabinose, and the amino acids alanine, glutamic acid, leucine, cysteine, and serine-all of which are highly soluble. We find that selective uptake is not evident unless (1) each sugar is tested individually and (2) multiple amino acids are tested together in a mixture. Combining sugars should be avoided because, as we show in Bacillus bacteria, the same organisms may catabolize one sugar, glucose, in D-form and another sugar, arabinose, in L-form. Single amino acids should be avoided because bacteria can access certain proteinogenically incompatible enantiomers using specific racemases. Specifically, bacteria contain an alanine acid racemase and can catabolize D-alanine if no other D-amino acids are present. The proposed improvements would reliably separate nonselective chemical reactions from biological reactions and, if life is indicated, inform whether the selective patterns for amino acids and sugars are the same as on Earth.
英文关键词	Atacama Desert Life detection Chirality Bacillus Metabolism
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000642506100001
WOS类目	Astronomy & Astrophysics ; Biology ; Geosciences, Multidisciplinary
WOS研究方向	Astronomy & Astrophysics ; Life Sciences & Biomedicine - Other Topics ; Geology
来源机构	中国科学院新疆生态与地理研究所 ; Universidad Nacional Autónoma de México ; Desert Research Institute
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/349595
作者单位	[Zhang, Ling; Zeng, Fanjiang] Chinese Acad Sci, Xinjiang Inst Ecol & Geog, State Key Lab Desert & Oasis Ecol, Urumqi, Peoples R China; [Zhang, Ling; Zeng, Fanjiang] Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Xinjiang Desert Plant Roots Ecol & Vegetat Restor, Urumqi, Peoples R China; [Zhang, Ling; Zeng, Fanjiang] Cele Natl Stn Observat & Res Desert Grassland Eco, Xinjiang, Peoples R China; [Zhang, Ling; Zeng, Fanjiang] Univ Chinese Acad Sci, Beijing, Peoples R China; [McKay, Christopher P.] NASA, Ames Res Ctr, Div Space Sci, Moffett Field, CA 94035 USA; [Navarro-Gonzalez, Rafael] Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Lab Quim Plasmas & Estudios Planetarios, Mexico City, DF, Mexico; [Sun, Henry J.] Desert Res Inst, Div Earth & Ecosyst Sci, Las Vegas, NV USA
推荐引用方式 GB/T 7714	Zhang, Ling,Zeng, Fanjiang,McKay, Christopher P.,et al. Optimizing Chiral Selectivity in Practical Life-Detection Instruments[J]. 中国科学院新疆生态与地理研究所, Universidad Nacional Autónoma de México, Desert Research Institute,2021,21(5):505-510.
APA	Zhang, Ling,Zeng, Fanjiang,McKay, Christopher P.,Navarro-Gonzalez, Rafael,&Sun, Henry J..(2021).Optimizing Chiral Selectivity in Practical Life-Detection Instruments.ASTROBIOLOGY,21(5),505-510.
MLA	Zhang, Ling,et al."Optimizing Chiral Selectivity in Practical Life-Detection Instruments".ASTROBIOLOGY 21.5(2021):505-510.