干旱区生态环境知识资源中心(Arid): Comparative Study of Anti-Inflammatory Effect on DSS-Induced Ulcerative Colitis Between Novel Glycyrrhiza Variety and Official Compendia

Arid

DOI	10.3390/app11041545
	Comparative Study of Anti-Inflammatory Effect on DSS-Induced Ulcerative Colitis Between Novel Glycyrrhiza Variety and Official Compendia
	Kang, Sa-Haeng; Song, Young-Jae; Jeon, Yong-Deok; Kim, Dong-Keun; Park, Jeong-Hyang; Soh, Ju-Ryoun; Lee, Jong-Hyun; Kitalong, Christopher; Kim, Wonnam; An, Hyo-Jin; Chang, Jae-Ki; Lee, Jeonghoon; Jin, Jong-Sik
通讯作者	Jin, JS (corresponding author), Jeonbuk Natl Univ, Dept Oriental Med Resources, Iksan 54596, Jeollabuk Do, South Korea. ; Lee, J (corresponding author), NIHHS, RDA, Herbal Crop Res Div, Chungbuk 27709, South Korea.
来源期刊	APPLIED SCIENCES-BASEL
EISSN	2076-3417
出版年	2021
卷号	11 期号:4
英文摘要	Glycyrrhizae radix (GR), a plant commonly referred to as licorice, is used as a medicine and food worldwide. However, the utilization of GR from wild areas has caused desertification and a depletion of natural resources. Environmental restrictions and low productivity have limited plant cultivation. For this reason, an improved Glycyrrhiza variety, Wongam (WG), in cultivation and quality has been developed by Korea Rural Development Administration. To evaluate the equivalence of efficacy, several comparative studies between already-registered species and new cultivars have been conducted. This study evaluated the anti-inflammatory effect of WG extracts in a dextran sulfate sodium (DSS)-induced colitis model, in comparison to that of GR extracts. WG extract significantly improved the clinical signs of DSS-induced ulcerative colitis, including disease activity index, body weight loss, and colon length shortening, which was equivalent to the effect of GR. Furthermore, the fecal microbiota was analyzed by terminal restriction fragment length polymorphism. The composition of the fecal microbiota did not show a specific pattern based on experimental groups; however, a tendency toward an increase in the proportion of Lactobacillales was observed. These findings showed an equivalence of efficacy and the possible utilization of WG as a medicinal resource with already-registered species.
英文关键词	improved glycyrrhiza varieties wongam ulcerative colitis inflammation fecal microbiota
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000632119200001
WOS类目	Chemistry, Multidisciplinary ; Engineering, Multidisciplinary ; Materials Science, Multidisciplinary ; Physics, Applied
WOS研究方向	Chemistry ; Engineering ; Materials Science ; Physics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/349502
作者单位	[Kang, Sa-Haeng; Song, Young-Jae; Kim, Dong-Keun; Park, Jeong-Hyang; Soh, Ju-Ryoun; Jin, Jong-Sik] Jeonbuk Natl Univ, Dept Oriental Med Resources, Iksan 54596, Jeollabuk Do, South Korea; [Jeon, Yong-Deok] Woosuk Univ, Coll Pharm, Dept Korean Pharm, 443 Samrye Ro, Wonju 55338, Jeollabuk Do, South Korea; [Lee, Jong-Hyun] Dongduk Womens Univ, Coll Pharm, Dept Pharm, 60 Hwarang Ro 13-Gil, Seoul 02748, South Korea; [Kitalong, Christopher] Pacific Acad Inst Res, Palau Community Coll, Cooperative Res Extens,9 Main St, Koror 96940, Palau; [Kim, Wonnam] Semyung Univ, Coll Korean Med, Div Pharmacol, 65 Semyung Ro, Chungbuk 27136, South Korea; [An, Hyo-Jin] Sangji Univ, Coll Korean Med, Dept Pharmacol, Wonju 26339, Gangwon Do, South Korea; [Chang, Jae-Ki; Lee, Jeonghoon] NIHHS, RDA, Herbal Crop Res Div, Chungbuk 27709, South Korea
推荐引用方式 GB/T 7714	Kang, Sa-Haeng,Song, Young-Jae,Jeon, Yong-Deok,et al. Comparative Study of Anti-Inflammatory Effect on DSS-Induced Ulcerative Colitis Between Novel Glycyrrhiza Variety and Official Compendia[J],2021,11(4).
APA	Kang, Sa-Haeng.,Song, Young-Jae.,Jeon, Yong-Deok.,Kim, Dong-Keun.,Park, Jeong-Hyang.,...&Jin, Jong-Sik.(2021).Comparative Study of Anti-Inflammatory Effect on DSS-Induced Ulcerative Colitis Between Novel Glycyrrhiza Variety and Official Compendia.APPLIED SCIENCES-BASEL,11(4).
MLA	Kang, Sa-Haeng,et al."Comparative Study of Anti-Inflammatory Effect on DSS-Induced Ulcerative Colitis Between Novel Glycyrrhiza Variety and Official Compendia".APPLIED SCIENCES-BASEL 11.4(2021).