干旱区生态环境知识资源中心(Arid): Evaluating the Effect of Intensity Standardisation on Longitudinal Whole Brain Atrophy Quantification in Brain Magnetic Resonance Imaging

Arid

DOI	10.3390/app11041773
	Evaluating the Effect of Intensity Standardisation on Longitudinal Whole Brain Atrophy Quantification in Brain Magnetic Resonance Imaging
	Carvajal-Camelo, Emily E.; Bernal, Jose; Oliver, Arnau; Llado, Xavier; Trujillo, Maria
通讯作者	Carvajal-Camelo, EE (corresponding author), Univ Valle, Multimedia & Comp Vis Grp, Cali 760001, Colombia. ; Bernal, J (corresponding author), Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh EH16 4ST, Midlothian, Scotland.
来源期刊	APPLIED SCIENCES-BASEL
EISSN	2076-3417
出版年	2021
卷号	11 期号:4
英文摘要	Atrophy quantification is fundamental for understanding brain development and diagnosing and monitoring brain diseases. FSL-SIENA is a well-known fully automated method that has been widely used in brain magnetic resonance imaging studies. However, intensity variations arising during image acquisition may compromise evaluation, analysis and even diagnosis. In this work, we studied whether intensity standardisation could improve longitudinal atrophy quantification using FSL-SIENA. We evaluated the effect of six intensity standardisation methods-z-score, fuzzy c-means, Gaussian mixture model, kernel density estimation, histogram matching and WhiteStripe-on atrophy detected by FSL-SIENA. First, we evaluated scan-rescan repeatability using scans taken during the same session from OASIS (n = 122). Except for WhiteStripe, intensity standardisation did not compromise the scan-rescan repeatability of FSL-SIENA. Second, we compared the mean annual atrophy for Alzheimer's and control subjects from OASIS (n = 122) and ADNI (n = 147) yielded by FSL-SIENA with and without intensity standardisation, after adjusting for covariates. Our findings were threefold: First, the use of histogram matching was counterproductive, primarily as its assumption of equal tissue proportions does not necessarily hold in longitudinal studies. Second, standardising with z-score and WhiteStripe before registration affected the registration performance, thus leading to erroneous estimates. Third, z-score was the only method that consistently led to increased effect sizes compared to when omitted (no standardisation: 0.39 and 0.43 for OASIS and ADNI; z-score: 0.45 for both datasets). Overall, we found that incorporating z-score right after registration led to reduced inter-subject inter-scan intensity variability and benefited FSL-SIENA. Our work evinces the relevance of appropriate intensity standardisation in longitudinal cerebral atrophy assessments using FSL-SIENA.
英文关键词	intensity standardisation FSL-SIENA longitudinal atrophy quantification brain magnetic resonance imaging
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000632108100001
WOS类目	Chemistry, Multidisciplinary ; Engineering, Multidisciplinary ; Materials Science, Multidisciplinary ; Physics, Applied
WOS研究方向	Chemistry ; Engineering ; Materials Science ; Physics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/349500
作者单位	[Carvajal-Camelo, Emily E.; Trujillo, Maria] Univ Valle, Multimedia & Comp Vis Grp, Cali 760001, Colombia; [Bernal, Jose] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh EH16 4ST, Midlothian, Scotland; [Oliver, Arnau; Llado, Xavier] Univ Girona, Comp Vis & Robot Inst, Girona 17003, Spain; [Oliver, Arnau; Llado, Xavier] Red Espanola Esclerosis Multiple REEM, Madrid 28040, Spain
推荐引用方式 GB/T 7714	Carvajal-Camelo, Emily E.,Bernal, Jose,Oliver, Arnau,et al. Evaluating the Effect of Intensity Standardisation on Longitudinal Whole Brain Atrophy Quantification in Brain Magnetic Resonance Imaging[J],2021,11(4).
APA	Carvajal-Camelo, Emily E.,Bernal, Jose,Oliver, Arnau,Llado, Xavier,&Trujillo, Maria.(2021).Evaluating the Effect of Intensity Standardisation on Longitudinal Whole Brain Atrophy Quantification in Brain Magnetic Resonance Imaging.APPLIED SCIENCES-BASEL,11(4).
MLA	Carvajal-Camelo, Emily E.,et al."Evaluating the Effect of Intensity Standardisation on Longitudinal Whole Brain Atrophy Quantification in Brain Magnetic Resonance Imaging".APPLIED SCIENCES-BASEL 11.4(2021).