Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.3390/antibiotics10060682 |
| The Extremophilic Actinobacteria: From Microbes to Medicine | |
| Hui, Martha Lok-Yung; Tan, Loh Teng-Hern; Letchumanan, Vengadesh; He, Ya-Wen; Fang, Chee-Mun; Chan, Kok-Gan; Law, Jodi Woan-Fei; Lee, Learn-Han | |
| 通讯作者 | Law, JWF ; Lee, LH (corresponding author), Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Microbiome & Bioresource Res Strength MBRS, Novel Bacteria & Drug Discovery Res Grp NBDD, Bandar Sunway 47500, Malaysia. ; Chan, KG (corresponding author), Univ Malaya, Fac Sci, Inst Biol Sci, Div Genet & Mol Biol, Kuala Lumpur 50603, Malaysia. ; Chan, KG (corresponding author), Jiangsu Univ, Int Genome Ctr, Zhenjiang 212013, Jiangsu, Peoples R China. ; Chan, KG (corresponding author), UCSI Univ, Fac Sci Appl, Kuala Lumpur 50600, Malaysia. |
| 来源期刊 | ANTIBIOTICS-BASEL
 |
| ISSN | 2079-6382 |
| 出版年 | 2021 |
| 卷号 | 10期号:6 |
| 英文摘要 | Actinobacteria constitute prolific sources of novel and vital bioactive metabolites for pharmaceutical utilization. In recent years, research has focused on exploring actinobacteria that thrive in extreme conditions to unearth their beneficial bioactive compounds for natural product drug discovery. Natural products have a significant role in resolving public health issues such as antibiotic resistance and cancer. The breakthrough of new technologies has overcome the difficulties in sampling and culturing extremophiles, leading to the outpouring of more studies on actinobacteria from extreme environments. This review focuses on the diversity and bioactive potentials/medically relevant biomolecules of extremophilic actinobacteria found from various unique and extreme niches. Actinobacteria possess an excellent capability to produce various enzymes and secondary metabolites to combat harsh conditions. In particular, a few strains have displayed substantial antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), shedding light on the development of MRSA-sensitive antibiotics. Several strains exhibited other prominent bioactivities such as antifungal, anti-HIV, anticancer, and anti-inflammation. By providing an overview of the recently found extremophilic actinobacteria and their important metabolites, we hope to enhance the understanding of their potential for the medical world. |
| 英文关键词 | extremophile actinobacteria environment bioactivity metabolites |
| 类型 | Review |
| 语种 | 英语 |
| 开放获取类型 | Green Published, gold |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000667867400001 |
| WOS关键词 | SP NOV. ; GENOME SEQUENCE ; ATACAMA DESERT ; A-D ; STREPTOMYCES ; STRAIN ; BIOREMEDIATION ; IDENTIFICATION ; ANTIBACTERIAL ; MICROBIOLOGY |
| WOS类目 | Infectious Diseases ; Pharmacology & Pharmacy |
| WOS研究方向 | Infectious Diseases ; Pharmacology & Pharmacy |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/349476 |
| 作者单位 | [Hui, Martha Lok-Yung; Tan, Loh Teng-Hern; Letchumanan, Vengadesh; Law, Jodi Woan-Fei; Lee, Learn-Han] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Microbiome & Bioresource Res Strength MBRS, Novel Bacteria & Drug Discovery Res Grp NBDD, Bandar Sunway 47500, Malaysia; [Tan, Loh Teng-Hern] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Clin Sch Johor Bahru, Johor Baharu 80100, Malaysia; [He, Ya-Wen] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Joint Int Res Lab Metab & Dev Sci, Sch Life Sci & Biotechnol, Shanghai 200030, Peoples R China; [Fang, Chee-Mun] Univ Nottingham Malaysia, Sch Pharm, Div Biomed Sci, Semenyih 43500, Selangor, Malaysia; [Chan, Kok-Gan] Univ Malaya, Fac Sci, Inst Biol Sci, Div Genet & Mol Biol, Kuala Lumpur 50603, Malaysia; [Chan, Kok-Gan] Jiangsu Univ, Int Genome Ctr, Zhenjiang 212013, Jiangsu, Peoples R China; [Chan, Kok-Gan] UCSI Univ, Fac Sci Appl, Kuala Lumpur 50600, Malaysia |
| 推荐引用方式 GB/T 7714 | Hui, Martha Lok-Yung,Tan, Loh Teng-Hern,Letchumanan, Vengadesh,et al. The Extremophilic Actinobacteria: From Microbes to Medicine[J],2021,10(6). |
| APA | Hui, Martha Lok-Yung.,Tan, Loh Teng-Hern.,Letchumanan, Vengadesh.,He, Ya-Wen.,Fang, Chee-Mun.,...&Lee, Learn-Han.(2021).The Extremophilic Actinobacteria: From Microbes to Medicine.ANTIBIOTICS-BASEL,10(6). |
| MLA | Hui, Martha Lok-Yung,et al."The Extremophilic Actinobacteria: From Microbes to Medicine".ANTIBIOTICS-BASEL 10.6(2021). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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