干旱区生态环境知识资源中心(Arid): Comparing the predictive values of five scales for 4-year all-cause mortality in critically ill elderly patients with sepsis

Arid

DOI	10.21037/apm-20-1355
	Comparing the predictive values of five scales for 4-year all-cause mortality in critically ill elderly patients with sepsis
	Jia, Linpei; Hao, Lixiao; Li, Xiaoxia; Jia, Rufu; Zhang, Hong-Liang
通讯作者	Jia, LP (corresponding author), Capital Med Univ, Xuanwu Hosp, Dept Nephrol, Changchun St 45, Beijing 100053, Peoples R China. ; Jia, RF (corresponding author), Cent Hosp Cangzhou, Adm Off, Xinhua Middle St 201, Cangzhou 061001, Peoples R China. ; Zhang, HL (corresponding author), Natl Nat Sci Fdn China, Dept Life Sci, Shuangqing Rd 83, Beijing 100085, Peoples R China.
来源期刊	ANNALS OF PALLIATIVE MEDICINE
ISSN	2224-5820
EISSN	2224-5839
出版年	2021
卷号	10 期号:3 页码:2387-2397
英文摘要	Background: Several severity scales have been documented to predict the short-term mortality of septic patients. However, the predictive efficacies of different severity scales in the long-term mortality of the elderly have yet to be evaluated. Methods: In the retrospective study, a cohort of 4,370 elderly (>= 65 years) septic patients admitted to the intensive care unit (ICU) were divided into three different age groups, i.e., the younger-old group (65 years <= age <75 years), the older-old group (75 years >= age <85 years) and the oldest-old group (age >= 85 years). Five scales, including the Simplified Acute Physiology Score II (SAPS II), the Oxford Acute Severity of Illness Score (OASIS), the Modified Logistic Organ Dysfunction System (MLODS), the Systemic Inflammatory Response Syndrome (SIRS) and Sequential Organ Failure Assessment (SOFA), were used for disease severity evaluations. The Kaplan-Meier survival curve, and the area under the receiver operating characteristic curve (AUC) were used to assess prognostic values of the long-term mortality of each severity scale. Results: Compared with patients in the oldest-old group, those in the younger-old and the older-old groups had higher scores of SAPS II and OASIS, indicating more serious illness and worse prognosis. The survival time of patients was inversely related to age; the mean survival time was the longest in the youngerold group, followed by the older-old group and the oldest-old group. SAPS II had the best prognostic value (AUC: 0.648 for SAPS II, 0.579 for MLODS, 0.577 for SOFA, 0.612 for OASIS and 0.515 for SIRS, P<0.01) for the 4-year all-cause mortality. Elderly patients with an SAPS II score >43 had a lower survival rate regardless of age. Conclusions: The long-term mortality of elderly patients with sepsis is increased with age. SAPS II can better predict the long-term prognosis of elderly septic patients in ICU.
英文关键词	Sepsis elderly the Simplified Acute Physiology Score II (SAPS II) long-term prognosis intensive care unit (ICU)
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000636466300001
WOS关键词	HOSPITAL MORTALITY ; ACUTE PHYSIOLOGY ; RISK PREDICTION ; ORGAN FAILURE ; CARE ; SCORE ; MANAGEMENT ; DEFINITIONS ; GUIDELINES ; SYSTEM
WOS类目	Health Care Sciences & Services
WOS研究方向	Health Care Sciences & Services
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/349468
作者单位	[Jia, Linpei; Li, Xiaoxia] Capital Med Univ, Xuanwu Hosp, Dept Nephrol, Changchun St 45, Beijing 100053, Peoples R China; [Hao, Lixiao] Capital Med Univ, Xuanwu Hosp, Dept Gen Practice, Beijing, Peoples R China; [Jia, Rufu] Cent Hosp Cangzhou, Adm Off, Xinhua Middle St 201, Cangzhou 061001, Peoples R China; [Zhang, Hong-Liang] Natl Nat Sci Fdn China, Dept Life Sci, Shuangqing Rd 83, Beijing 100085, Peoples R China
推荐引用方式 GB/T 7714	Jia, Linpei,Hao, Lixiao,Li, Xiaoxia,et al. Comparing the predictive values of five scales for 4-year all-cause mortality in critically ill elderly patients with sepsis[J],2021,10(3):2387-2397.
APA	Jia, Linpei,Hao, Lixiao,Li, Xiaoxia,Jia, Rufu,&Zhang, Hong-Liang.(2021).Comparing the predictive values of five scales for 4-year all-cause mortality in critically ill elderly patients with sepsis.ANNALS OF PALLIATIVE MEDICINE,10(3),2387-2397.
MLA	Jia, Linpei,et al."Comparing the predictive values of five scales for 4-year all-cause mortality in critically ill elderly patients with sepsis".ANNALS OF PALLIATIVE MEDICINE 10.3(2021):2387-2397.