干旱区生态环境知识资源中心(Arid): Genomic Analyses Reveal Adaptation to Hot Arid and Harsh Environments in Native Chickens of China

Arid

DOI	10.3389/fgene.2020.582355
	Genomic Analyses Reveal Adaptation to Hot Arid and Harsh Environments in Native Chickens of China
	Gu, Jingjing; Liang, Qiqi; Liu, Can; Li, Sheng
通讯作者	Gu, JJ (corresponding author), Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China. ; Gu, JJ (corresponding author), Hunan Prov Key Lab Genet Improvement Domest Anim, Changsha, Peoples R China. ; Gu, JJ (corresponding author), Hunan Engn Res Ctr Poultry Prod Safety, Changsha, Peoples R China. ; Li, S (corresponding author), Maxun Biotechnol Inst, Changsha, Peoples R China.
来源期刊	FRONTIERS IN GENETICS
EISSN	1664-8021
出版年	2020
卷号	11
英文摘要	The acute thermal response has been extensively studied in commercial chickens because of the adverse effects of heat stress on poultry production worldwide. Here, we performed whole-genome resequencing of autochthonous Niya chicken breed native to the Taklimakan Desert region as well as of 11 native chicken breeds that are widely distributed and reared under native humid and temperate areas. We used combined statistical analysis to search for putative genes that might be related to the adaptation of hot arid and harsh environment in Niya chickens. We obtained a list of intersected candidate genes with log2 theta pi ratio, FST and XP-CLR (including 123 regions of 21 chromosomes with the average length of 54.4 kb) involved in different molecular processes and pathways implied complex genetic mechanisms of adaptation of native chickens to hot arid and harsh environments. We identified several selective regions containing genes that were associated with the circulatory system and blood vessel development (BVES, SMYD1, IL18, PDGFRA, NRP1, and CORIN), related to central nervous system development (SIM2 and NALCN), related to apoptosis (CLPTM1L, APP, CRADD, and PARK2) responded to stimuli (AHR, ESRRG FAS, and UBE4B) and involved in fatty acid metabolism (FABP1). Our findings provided the genomic evidence of the complex genetic mechanisms of adaptation to hot arid and harsh environments in chickens. These results may improve our understanding of thermal, drought, and harsh environment acclimation in chickens and may serve as a valuable resource for developing new biotechnological tools to breed stress-tolerant chicken lines and or breeds in the future.
英文关键词	positive selection native chicken environmental adaption whole genome resequencing candidate genes
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000604291300001
WOS关键词	HEAT-STRESS ; DIFFERENTIATION ; EXPRESSION ; PROTEINS ; SEQUENCE ; TARGET ; IL-18
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348864
作者单位	[Gu, Jingjing] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China; [Gu, Jingjing] Hunan Prov Key Lab Genet Improvement Domest Anim, Changsha, Peoples R China; [Gu, Jingjing] Hunan Engn Res Ctr Poultry Prod Safety, Changsha, Peoples R China; [Liang, Qiqi; Liu, Can] Novogene Bioinformat Inst, Beijing, Peoples R China; [Li, Sheng] Maxun Biotechnol Inst, Changsha, Peoples R China
推荐引用方式 GB/T 7714	Gu, Jingjing,Liang, Qiqi,Liu, Can,et al. Genomic Analyses Reveal Adaptation to Hot Arid and Harsh Environments in Native Chickens of China[J],2020,11.
APA	Gu, Jingjing,Liang, Qiqi,Liu, Can,&Li, Sheng.(2020).Genomic Analyses Reveal Adaptation to Hot Arid and Harsh Environments in Native Chickens of China.FRONTIERS IN GENETICS,11.
MLA	Gu, Jingjing,et al."Genomic Analyses Reveal Adaptation to Hot Arid and Harsh Environments in Native Chickens of China".FRONTIERS IN GENETICS 11(2020).