干旱区生态环境知识资源中心(Arid): Unmet needs for treatment in 102 individuals with brief and limited intermittent psychotic symptoms (BLIPS): implications for current clinical recommendations

Arid

DOI	10.1017/S2045796019000635
	Unmet needs for treatment in 102 individuals with brief and limited intermittent psychotic symptoms (BLIPS): implications for current clinical recommendations
	Fusar-Poli, Paolo; De Micheli, Andrea; Chalambrides, Monica; Singh, Aoife; Augusto, Castagnini; McGuire, Philip
通讯作者	Fusar-Poli, P (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England. ; Fusar-Poli, P (corresponding author), South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England. ; Fusar-Poli, P (corresponding author), Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy. ; Fusar-Poli, P (corresponding author), South London & Maudsley NHS Fdn Trust, Maudsley Biomed Res Ctr, Natl Inst Hlth Res, London, England.
来源期刊	EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
ISSN	2045-7960
EISSN	2045-7979
出版年	2020
卷号	29
英文摘要	Aims. To investigate clinical outcomes and unmet needs in individuals at Clinical High Risk for Psychosis presenting with Brief and Limited Intermittent Psychotic Symptoms (BLIPS). Methods. Prospective naturalistic long-term (up to 9 years) cohort study in individuals meeting BLIPS criteria at the Outreach And Support In South-London (OASIS) up to April 2016. Baseline sociodemographic and clinical characteristics, specific BLIPS features, preventive treatments received and clinical outcomes (psychotic and non-psychotic) were measured. Analyses included Kaplan Meier survival estimates and Cox regression methods. Results. One hundred and two BLIPS individuals were followed up to 9 years. Across BLIPS cases, 35% had an abrupt onset; 32% were associated with acute stress, 45% with lifetime trauma and 20% with concurrent illicit substance use. The vast majority (80%) of BLIPS individuals, despite being systematically offered cognitive behavioural therapy for psychosis, did not fully engage with it and did not receive the minimum effective dose. Only 3% of BLIPS individuals received the appropriate dose of cognitive behavioural therapy. At 4-year follow-up, 52% of the BLIPS individuals developed a psychotic disorder, 34% were admitted to hospital and 16% received a compulsory admission. At 3-year follow-up, 52% of them received an antipsychotic treatment; at 4-year follow-up, 26% of them received an antidepressant treatment. The presence of seriously disorganising and dangerous features was a strong poor prognostic factor. Conclusions. BLIPS individuals display severe clinical outcomes beyond their very high risk of developing psychosis and show poor compliance with preventive cognitive behavioural therapy. BLIPS individuals have severe needs for treatment that are not met by current preventive strategies.
英文关键词	BLIPS brief psychotic episode prognosis psychosis risk schizophrenia prevention
类型	Article
语种	英语
开放获取类型	Green Submitted, hybrid, Green Published
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000585066900042
WOS关键词	ULTRA-HIGH RISK ; PEOPLE ; DISORDERS ; OUTCOMES ; INTERVENTIONS ; PREDICTION ; VALIDITY ; METAANALYSIS ; PROGRESSION ; SERVICES
WOS类目	Psychiatry
WOS研究方向	Psychiatry
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348833
作者单位	[Fusar-Poli, Paolo; De Micheli, Andrea] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England; [Fusar-Poli, Paolo; Chalambrides, Monica; Singh, Aoife] South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England; [Fusar-Poli, Paolo] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy; [Fusar-Poli, Paolo; McGuire, Philip] South London & Maudsley NHS Fdn Trust, Maudsley Biomed Res Ctr, Natl Inst Hlth Res, London, England; [Augusto, Castagnini] Univ Modena & Reggio Emilia, Sch Child Neuropsychiat, Modena, Italy; [McGuire, Philip] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
推荐引用方式 GB/T 7714	Fusar-Poli, Paolo,De Micheli, Andrea,Chalambrides, Monica,et al. Unmet needs for treatment in 102 individuals with brief and limited intermittent psychotic symptoms (BLIPS): implications for current clinical recommendations[J]. University of London,2020,29.
APA	Fusar-Poli, Paolo,De Micheli, Andrea,Chalambrides, Monica,Singh, Aoife,Augusto, Castagnini,&McGuire, Philip.(2020).Unmet needs for treatment in 102 individuals with brief and limited intermittent psychotic symptoms (BLIPS): implications for current clinical recommendations.EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES,29.
MLA	Fusar-Poli, Paolo,et al."Unmet needs for treatment in 102 individuals with brief and limited intermittent psychotic symptoms (BLIPS): implications for current clinical recommendations".EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES 29(2020).