干旱区生态环境知识资源中心(Arid): Involuntary human exposure to carbamazepine: A cross-sectional study of correlates across the lifespan and dietary spectrum

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DOI	10.1016/j.envint.2020.105951
	Involuntary human exposure to carbamazepine: A cross-sectional study of correlates across the lifespan and dietary spectrum
	Schapira, Michael; Manor, Orly; Golan, Naama; Kalo, Dorit; Mordehay, Vered; Kirshenbaum, Noam; Goldsmith, Rebecca; Chefetz, Benny; Paltiel, Ora
通讯作者	Paltiel, O (corresponding author), Hebrew Univ Jerusalem Hadassah, Braun Sch Publ Hlth & Community Med, IL-9112001 Jerusalem, Israel. ; Chefetz, B (corresponding author), Hebrew Univ Jerusalem, Dept Soil & Water Sci, Fac Agr Food & Environm, IL-7610001 Rehovot, Israel.
来源期刊	ENVIRONMENT INTERNATIONAL
ISSN	0160-4120
EISSN	1873-6750
出版年	2020
卷号	143
英文摘要	Treated wastewater (TWW) is increasingly used for agricultural irrigation, especially in arid and semi-arid regions. Carbamazepine is among the most frequently detected pharmaceuticals in TWW. Moreover, its uptake and accumulation have been demonstrated in crops irrigated with TWW. A previous controlled trial found that urine concentrations of carbamazepine were higher in healthy volunteers consuming TWW-irrigated produce as compared to freshwater-irrigated produce. The aim of the current study was to assess whether carbamazepine is quantifiable in urine of Israelis consuming their usual diets and whether concentrations vary according to age, personal characteristics and diet. In this cross-sectional study, we recruited 245 volunteers, including a reference group of omnivorous healthy adults aged 18-66; pregnant women; children aged 3-6 years; adults aged > 75 years; and vegetarians/vegans. Participants provided spot urine samples and reported 24-hour and usual dietary consumption. Urinary carbamazepine levels were compared according to group, personal characteristics, health behaviors, and reported diet. Carbamazepine was detectable (>= 1.66 ng/L) in urine of 84%, 76%, 75.5%, 66%, and 19.6% of the reference group, vegetarians, older adults, pregnant women, and children, respectively. Quantifiable concentrations (>= 5.0 ng/L) of carbamazepine were found in 58%, 46%, 36.7%, 14%, and 0% of these groups, respectively (p = 0.001 for comparison of proportions across groups). In adults, higher carbamazepine concentrations were significantly associated (p < 0.05) with self-defined vegetarianism, usual consumption of dairy products and at least five vegetables/day, and no meat or fish consumption in the past 24 hours. This study demonstrates that people living in a water-scarce region with widespread TWW irrigation, are unknowingly exposed to carbamazepine. Individuals adhering to recommended guidelines for daily fresh produce consumption may be at higher risk of exposure to TWW-derived contaminants of emerging concern.
英文关键词	Treated wastewater Pharmaceuticals Xenobiotics Water scarcity Irrigation
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000602318000028
WOS关键词	PERSONAL CARE PRODUCTS ; TREATED WASTE-WATER ; ANTIEPILEPTIC DRUGS ; PHARMACEUTICALS ; METABOLITES ; PLANT ; POPULATION ; BIOSOLIDS ; PPCPS
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
来源机构	Hebrew University of Jerusalem
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348823
作者单位	[Schapira, Michael; Manor, Orly; Goldsmith, Rebecca; Paltiel, Ora] Hebrew Univ Jerusalem Hadassah, Braun Sch Publ Hlth & Community Med, IL-9112001 Jerusalem, Israel; [Golan, Naama; Mordehay, Vered; Kirshenbaum, Noam; Chefetz, Benny] Hebrew Univ Jerusalem, Dept Soil & Water Sci, Fac Agr Food & Environm, IL-7610001 Rehovot, Israel; [Kalo, Dorit] Hebrew Univ Jerusalem, Robert H Smith Fac Agr Food & Environm, Dept Anim Sci, IL-7610001 Rehovot, Israel; [Goldsmith, Rebecca] Publ Hlth Serv, Israel Minist Hlth, Jerusalem, Israel
推荐引用方式 GB/T 7714	Schapira, Michael,Manor, Orly,Golan, Naama,et al. Involuntary human exposure to carbamazepine: A cross-sectional study of correlates across the lifespan and dietary spectrum[J]. Hebrew University of Jerusalem,2020,143.
APA	Schapira, Michael.,Manor, Orly.,Golan, Naama.,Kalo, Dorit.,Mordehay, Vered.,...&Paltiel, Ora.(2020).Involuntary human exposure to carbamazepine: A cross-sectional study of correlates across the lifespan and dietary spectrum.ENVIRONMENT INTERNATIONAL,143.
MLA	Schapira, Michael,et al."Involuntary human exposure to carbamazepine: A cross-sectional study of correlates across the lifespan and dietary spectrum".ENVIRONMENT INTERNATIONAL 143(2020).