干旱区生态环境知识资源中心(Arid): Presumptive heterophil extracellular traps recognized cytologically in nine reptile patients with inflammatory conditions

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DOI	10.1080/01652176.2021.1873453
	Presumptive heterophil extracellular traps recognized cytologically in nine reptile patients with inflammatory conditions
	Flanders, A. J.; Ossiboff, R. J.; Wellehan, J. F. X., Jr.; Alexander, A. B.; Fredholm, D. V. E.; Desiderio, T. M.; Stacy, N. I.
通讯作者	Stacy, NI (corresponding author), Univ Florida, Coll Vet Med, Dept Comparat Diagnost & Populat Med, Gainesville, FL 32610 USA.
来源期刊	VETERINARY QUARTERLY
ISSN	0165-2176
EISSN	1875-5941
出版年	2021
卷号	41 期号:1 页码:89-96
英文摘要	Background: Neutrophil extracellular traps (NETs) represent a novel cellular mechanism of antimicrobial defense activity. Intravascular neutrophils produce extracellular web-like structures composed of chromatin, histones, and cytoplasmic granule proteins to attack and kill microbes. They may impact both pathogen and host; NETs correlate strongly with disseminated intravascular coagulation and mortality in critically ill humans. The mechanism was first discovered in human neutrophils in 2004. Presumptive heterophil extracellular traps (HETs) in a non-avian reptile species were first described in blood films of a gopher tortoise with systemic inflammation. Objective: While prior reports are limited to blood film review and in vitro studies, this descriptive case series highlights the cytological identification of presumptive HETs in nine reptile patients. Methods: Subjects included six gopher tortoises, one blood python (Python curtus), one Burmese python (P. bivittatus), and one desert king snake (Lampropeltis getula splendida). All six gopher tortoises (Gopherus polyphemus) had upper respiratory disease with bacterial etiology (including Helicobacter sp. and/or Mycoplasma sp.), and snakes had upper respiratory tract infection confirmed with serpentovirus (n = 2) or bacterial dermatitis (n = 1). Results: Cytology samples with identified HETs included tissue imprints (n = 4), nasal discharge (n = 3), an oral swab (n = 1), and a fine needle aspirate of a skin lesion (n = 1). The identification of specific bacterial (n = 6) and/or viral pathogens (n = 2) was notable.
英文关键词	Reptile cytology extracellular traps inflammation
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000608451200001
WOS类目	Veterinary Sciences
WOS研究方向	Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348256
作者单位	[Flanders, A. J.; Ossiboff, R. J.; Wellehan, J. F. X., Jr.; Alexander, A. B.; Desiderio, T. M.; Stacy, N. I.] Univ Florida, Coll Vet Med, Dept Comparat Diagnost & Populat Med, Gainesville, FL 32610 USA; [Fredholm, D. V. E.; Stacy, N. I.] Disneys Anim Kingdom, Disneys Anim Sci & Environm, Bay Lake, FL USA
推荐引用方式 GB/T 7714	Flanders, A. J.,Ossiboff, R. J.,Wellehan, J. F. X., Jr.,et al. Presumptive heterophil extracellular traps recognized cytologically in nine reptile patients with inflammatory conditions[J],2021,41(1):89-96.
APA	Flanders, A. J..,Ossiboff, R. J..,Wellehan, J. F. X., Jr..,Alexander, A. B..,Fredholm, D. V. E..,...&Stacy, N. I..(2021).Presumptive heterophil extracellular traps recognized cytologically in nine reptile patients with inflammatory conditions.VETERINARY QUARTERLY,41(1),89-96.
MLA	Flanders, A. J.,et al."Presumptive heterophil extracellular traps recognized cytologically in nine reptile patients with inflammatory conditions".VETERINARY QUARTERLY 41.1(2021):89-96.