干旱区生态环境知识资源中心(Arid): Establishing a clinical service to prevent psychosis: What, how and when? Systematic review

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DOI	10.1038/s41398-020-01165-x
	Establishing a clinical service to prevent psychosis: What, how and when? Systematic review
	de Pablo, Gonzalo Salazar; Estrade, Andres; Cutroni, Marcello; Andlauer, Olivier; Fusar-Poli, Paolo
通讯作者	Fusar-Poli, P (corresponding author), Kings Coll London, Early Psychosis Intervent & Clin Detect EPIC Lab, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England. ; Fusar-Poli, P (corresponding author), Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy. ; Fusar-Poli, P (corresponding author), South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res, Maudsley Biomed Res Ctr, London, England. ; Fusar-Poli, P (corresponding author), South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England.
来源期刊	TRANSLATIONAL PSYCHIATRY
ISSN	2158-3188
出版年	2021
卷号	11 期号:1
英文摘要	The first rate-limiting step to successfully translate prevention of psychosis in to clinical practice is to establish specialised Clinical High Risk for Psychosis (CHR-P) services. This study systematises the knowledge regarding CHR-P services and provides guidelines for translational implementation. We conducted a PRISMA/MOOSE-compliant (PROSPERO-CRD42020163640) systematic review of Web of Science to identify studies until 4/05/2020 reporting on CHR-P service configuration, outreach strategy and referrals, service user characteristics, interventions, and outcomes. Fifty-six studies (1998-2020) were included, encompassing 51 distinct CHR-P services across 15 countries and a catchment area of 17,252,666 people. Most services (80.4%) consisted of integrated multidisciplinary teams taking care of CHR-P and other patients. Outreach encompassed active (up to 97.6%) or passive (up to 63.4%) approaches: referrals came mostly (90%) from healthcare agencies. CHR-P individuals were more frequently males (57.2%). Most (70.6%) services accepted individuals aged 12-35 years, typically assessed with the CAARMS/SIPS (83.7%). Baseline comorbid mental conditions were reported in two-third (69.5%) of cases, and unemployment in one third (36.6%). Most services provided up to 2-years (72.4%), of clinical monitoring (100%), psychoeducation (81.1%), psychosocial support (73%), family interventions (73%), individual (67.6%) and group (18.9%) psychotherapy, physical health interventions (37.8%), antipsychotics (87.1%), antidepressants (74.2%), anxiolytics (51.6%), and mood stabilisers (38.7%). Outcomes were more frequently ascertained clinically (93.0%) and included: persistence of symptoms/comorbidities (67.4%), transition to psychosis (53.5%), and functional status (48.8%). We provide ten practical recommendations for implementation of CHR-P services. Health service knowledge summarised by the current study will facilitate translational efforts for implementation of CHR-P services worldwide.
类型	Review
语种	英语
开放获取类型	Green Submitted, gold, Green Published
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000609920200002
WOS关键词	ULTRA-HIGH-RISK ; SOUTH LONDON OASIS ; EARLY INTERVENTION SERVICES ; ACHIEVEMENT PROGRAM SWAP ; METHODS APPRAISAL TOOL ; MENTAL STATE ARMS ; AT-RISK ; YOUNG-PEOPLE ; 1ST-EPISODE PSYCHOSIS ; PREDICTING PSYCHOSIS
WOS类目	Psychiatry
WOS研究方向	Psychiatry
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348250
作者单位	[de Pablo, Gonzalo Salazar; Estrade, Andres; Fusar-Poli, Paolo] Kings Coll London, Early Psychosis Intervent & Clin Detect EPIC Lab, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England; [de Pablo, Gonzalo Salazar] Univ Complutense, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat,CIBERSAM, Hosp Gen Univ Gregorio Maranon,Sch Med,Inst Inves, Madrid, Spain; [Estrade, Andres] Catholic Univ, Dept Clin & Hlth Psychol, Montevideo, Uruguay; [Cutroni, Marcello; Fusar-Poli, Paolo] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy; [Andlauer, Olivier] East London NHS Fdn Trust, Heads UP Serv, London, England; [Andlauer, Olivier] Queen Mary Univ London, Ctr Psychiat, Wolfson Inst Prevent Med, Barts & London Sch Med & Dent, London, England; [Fusar-Poli, Paolo] South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res, Maudsley Biomed Res Ctr, London, England; [Fusar-Poli, Paolo] South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England
推荐引用方式 GB/T 7714	de Pablo, Gonzalo Salazar,Estrade, Andres,Cutroni, Marcello,et al. Establishing a clinical service to prevent psychosis: What, how and when? Systematic review[J]. University of London,2021,11(1).
APA	de Pablo, Gonzalo Salazar,Estrade, Andres,Cutroni, Marcello,Andlauer, Olivier,&Fusar-Poli, Paolo.(2021).Establishing a clinical service to prevent psychosis: What, how and when? Systematic review.TRANSLATIONAL PSYCHIATRY,11(1).
MLA	de Pablo, Gonzalo Salazar,et al."Establishing a clinical service to prevent psychosis: What, how and when? Systematic review".TRANSLATIONAL PSYCHIATRY 11.1(2021).