干旱区生态环境知识资源中心(Arid): Swine hemorrhagic shock model and pathophysiological changes in a desert dry-heat environment

Arid

DOI	10.1371/journal.pone.0244727
	Swine hemorrhagic shock model and pathophysiological changes in a desert dry-heat environment
	Shen, Caifu; Wei, Dunhong; Wang, Guangjun; Kang, Yan; Yang, Fan; Xu, Qin; Xia, Liang; Liu, Jiangwei
通讯作者	Liu, JW (corresponding author), Chinese Peoples Liberat Army, Xinjiang Mil Command, Gen Hosp, Key Lab Special Environm Med Xinjiang, Urumqi, Peoples R China.
来源期刊	PLOS ONE
ISSN	1932-6203
出版年	2021
卷号	16 期号:1
英文摘要	Background This study aimed to establish a traumatic hemorrhagic shock (THS) model in swine and examine pathophysiological characteristics in a dry-heat environment. Methods Forty domestic Landrace piglets were randomly assigned to four study groups: normal temperature non-shock (NS), normal temperature THS (NTHS), desert dry-heat non-shock (DS), and desert dry-hot THS (DTHS) groups. The groups were exposed to either normal temperature (25 degrees C) or dry heat (40.5 degrees C) for 3 h. To induce THS, anesthetized piglets in the NTHS and DTHS groups were subjected to liver trauma and hypovolemic shock until death, and piglets in the NS and DS groups were euthanized at 11 h and 4 h, respectively. Body temperature, blood gas, cytokine production, and organ function were assessed before and after environmental exposure at 0 h and at every 30 min after shock to death. Hemodynamics was measured post exposure and post-shock at 0 h and at every 30 min after shock to death. Results Survival, body temperature, oxygen delivery, oxygen consumption, and cardiac output were significantly different for traumatic hemorrhagic shock in the dry-heat groups compared to those in the normal temperature groups. Lactic acid and IL-6 had a marked increase at 0.5 h, followed by a progressive and rapid increase in the DTHS group. Conclusions Our findings suggest that the combined action of a dry-heat environment and THS leads to higher oxygen metabolism, poorer hemodynamic stability, and earlier and more severe inflammatory response with higher mortality.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000607070700016
WOS关键词	ORGAN DYSFUNCTION ; RESUSCITATION ; TEMPERATURE ; INHIBITION ; MECHANISMS ; EVENTS ; VOLUME
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348105
作者单位	[Shen, Caifu; Wei, Dunhong; Wang, Guangjun; Yang, Fan; Xu, Qin; Xia, Liang; Liu, Jiangwei] Chinese Peoples Liberat Army, Xinjiang Mil Command, Gen Hosp, Key Lab Special Environm Med Xinjiang, Urumqi, Peoples R China; [Kang, Yan] Chinese Peoples Liberat Army, Army Hosp 69240, Xinjiang, Urumqi, Peoples R China
推荐引用方式 GB/T 7714	Shen, Caifu,Wei, Dunhong,Wang, Guangjun,et al. Swine hemorrhagic shock model and pathophysiological changes in a desert dry-heat environment[J],2021,16(1).
APA	Shen, Caifu.,Wei, Dunhong.,Wang, Guangjun.,Kang, Yan.,Yang, Fan.,...&Liu, Jiangwei.(2021).Swine hemorrhagic shock model and pathophysiological changes in a desert dry-heat environment.PLOS ONE,16(1).
MLA	Shen, Caifu,et al."Swine hemorrhagic shock model and pathophysiological changes in a desert dry-heat environment".PLOS ONE 16.1(2021).