干旱区生态环境知识资源中心(Arid): Determination of Pharmaceuticals Discharged in Wastewater from a Public Hospital Using LC-MS/MS Technique

Arid

DOI	10.29356/jmcs.v65i1.1439
	Determination of Pharmaceuticals Discharged in Wastewater from a Public Hospital Using LC-MS/MS Technique
	Hernandez-Tenorio, Rafael; Guzman-Mar, Jorge Luis; Hinojosa-Reyes, Laura; Ramos-Delgado, Norma; Hernandez-Ramirez, Aracely
通讯作者	Hernandez-Ramirez, A (corresponding author), Univ Autonoma Nuevo Lean, UANL, Fac Ciencias Quim, Cd Univ,Av Univ S-N, San Nicolas De Los Garza 66455, Nuevo Leon, Mexico.
来源期刊	JOURNAL OF THE MEXICAN CHEMICAL SOCIETY
ISSN	1870-249X
EISSN	1665-9686
出版年	2021
卷号	65 期号:1 页码:94-108
英文摘要	The presence of pharmaceuticals classified as emerging contaminants (EC) in surface water, groundwater, and drinking water generates uncertainty concerning the interactions that could be occurred with aquatic organisms and living beings. Thus, the monitoring of hospital wastewater is of great importance to identify the main classes of pharmaceuticals that could be discharged to the municipal sewage system and wastewater treatment plants (WWTPs). This work described the implementation and validation of a highly selective and sensitive analytical method using solid-phase extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the detection and quantification of these emerging compounds. The solid-phase extraction (SPE) method was employed using Oasis HLB cartridges. For LC-MS/MS analysis, the chromatographic separation was conducted in a C-18 Kinetex column (Phenomenex), and detection was achieved in an AB SCIEX QTrap 3200 tandem mass spectrometer (MS/MS) in the multiple reaction monitoring (MRM) mode. The quantitative analysis was performed by using the internal standard (IS) method with isotopically labeled analogs. The implemented method presented good linearity within the concentration range of 0.1-400 mu g L-1 showing correlation coefficients (R-2) ranged from 0.991 to 0.999. The limits of detection (LODs) were from 0.02 to 0.59 mu g L-1, while the limits of quantification (LOQs) ranged from 0.07 to 1.80 mu g L-1. The analytical method was successfully applied to the analysis of wastewater samples discharged by a public hospital in San Nicolas de los Garza, Nuevo Leon, Mexico, in two sampling periods: May 2017 and March 2018.
英文关键词	Emerging contaminants pharmaceuticals hospital effluent solid phase extraction LC-MS/MS
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000604965000009
WOS关键词	PERSONAL CARE PRODUCTS ; TANDEM MASS-SPECTROMETRY ; TREATMENT PLANTS ; EMERGING POLLUTANTS ; CONTAMINANTS ; FATE ; METABOLITES ; EFFLUENTS ; IDENTIFICATION ; GROUNDWATER
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348048
作者单位	[Hernandez-Tenorio, Rafael; Guzman-Mar, Jorge Luis; Hinojosa-Reyes, Laura; Hernandez-Ramirez, Aracely] Univ Autonoma Nuevo Lean, UANL, Fac Ciencias Quim, Cd Univ,Av Univ S-N, San Nicolas De Los Garza 66455, Nuevo Leon, Mexico; [Ramos-Delgado, Norma] CONACYT Inst Tecnol Nuevo Lean, Ctr Invest & Innovac Tecnol, Av Alianza 507,Inside Pk PIIT, Apodaca 66629, Nuevo Leon, Mexico
推荐引用方式 GB/T 7714	Hernandez-Tenorio, Rafael,Guzman-Mar, Jorge Luis,Hinojosa-Reyes, Laura,et al. Determination of Pharmaceuticals Discharged in Wastewater from a Public Hospital Using LC-MS/MS Technique[J],2021,65(1):94-108.
APA	Hernandez-Tenorio, Rafael,Guzman-Mar, Jorge Luis,Hinojosa-Reyes, Laura,Ramos-Delgado, Norma,&Hernandez-Ramirez, Aracely.(2021).Determination of Pharmaceuticals Discharged in Wastewater from a Public Hospital Using LC-MS/MS Technique.JOURNAL OF THE MEXICAN CHEMICAL SOCIETY,65(1),94-108.
MLA	Hernandez-Tenorio, Rafael,et al."Determination of Pharmaceuticals Discharged in Wastewater from a Public Hospital Using LC-MS/MS Technique".JOURNAL OF THE MEXICAN CHEMICAL SOCIETY 65.1(2021):94-108.