干旱区生态环境知识资源中心(Arid): High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry

Arid

DOI	10.1016/j.jpba.2020.113764
	High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry
	Tanaka, Ryota; Kai, Makoto; Goto, Koji; Ohchi, Yoshifumi; Yasuda, Norihisa; Tatsuta, Ryosuke; Kitano, Takaaki; Itoh, Hiroki
通讯作者	Tanaka, R (corresponding author), Oita Univ Hosp, Dept Clin Pharm, Yufu, Oita, Japan.
来源期刊	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN	0731-7085
EISSN	1873-264X
出版年	2021
卷号	194
英文摘要	Several recent studies on pharmacokinetics of linezolid (LZD) and daptomycin (DAP) reported that plasma concentration was linked to efficacy and adverse effects, suggesting the usefulness of therapeutic drug monitoring (TDM). The usefulness of TDM for tedizolid (TZD) has not been reported, but a previous report showed individual differences in area under the curve depending on body weight. In intensive care unit (ICU) patients, pharmacokinetics was reported to fluctuate due to various factors. Here, we developed a high-throughput and wide-range simultaneous quantification method for LZD, DAP and TZD in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLCMS/MS). Plasma samples were pretreated by solid-phase extraction using Oasis (R) HLB mu Elution Plate. The assay fulfilled the requirements of US Food and Drug Administration and the European Medicines Agency for bioanalytical method validation. The assay for LZD, DAP and TZD showed good linearity over wide ranges of 100-100000, 150-150000 and 5-5000 ng/mL, respectively. Within-batch accuracy and precision as well as batch-to-batch accuracy and precision for all three drugs fulfilled the criteria of the above guidance. Extraction recovery rates were more than 92.2 % for LZD, 44.7 % for DAP, and 84.8 % for TZD. Matrix effect showed no remarkable differences among low, medium and high quality control samples for the three drugs. The maximum and trough concentrations of three patients each who received LZD, DAP or TZD in ICU were measured by the novel UPLC-MS/MS method. In all patients, the measured concentrations were within the ranges of the calibration curves, demonstrating the feasibility of clinical application of the novel method. In conclusion, we have succeeded to develop the first method for simultaneous quantification of plasma concentrations of LZD, DAP and TZD. (C) 2020 Elsevier B.V. All rights reserved.
英文关键词	Linezolid Daptomycin Tedizolid Ultra-performance liquid chromatography coupled to tandem mass spectrometry Intensive care unit Therapeutic drug monitoring
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000605512600015
WOS关键词	SIMULTANEOUS QUANTIFICATION ; CIPROFLOXACIN ; PIPERACILLIN ; INFECTIONS ; MEROPENEM ; CEFEPIME ; EXPOSURE ; DIALYSIS ; BLOOD
WOS类目	Chemistry, Analytical ; Pharmacology & Pharmacy
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348033
作者单位	[Tanaka, Ryota; Kai, Makoto; Tatsuta, Ryosuke; Itoh, Hiroki] Oita Univ Hosp, Dept Clin Pharm, Yufu, Oita, Japan; [Goto, Koji; Ohchi, Yoshifumi; Yasuda, Norihisa; Kitano, Takaaki] Oita Univ Hosp, Dept Anesthesiol & Intens Care, Fac Med, Yufu, Oita, Japan
推荐引用方式 GB/T 7714	Tanaka, Ryota,Kai, Makoto,Goto, Koji,et al. High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry[J],2021,194.
APA	Tanaka, Ryota.,Kai, Makoto.,Goto, Koji.,Ohchi, Yoshifumi.,Yasuda, Norihisa.,...&Itoh, Hiroki.(2021).High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,194.
MLA	Tanaka, Ryota,et al."High-throughput and wide-range simultaneous determination of linezolid, daptomycin and tedizolid in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 194(2021).