干旱区生态环境知识资源中心(Arid): Ethnopharmacological uses, phytochemistry and pharmacological activities of Guiera senegalensis JF Gmel. (Combretaceae)

Arid

DOI	10.1016/j.jep.2020.113433
	Ethnopharmacological uses, phytochemistry and pharmacological activities of Guiera senegalensis JF Gmel. (Combretaceae)
	Dirar, Amina Ibrahim; Devkota, Hari Prasad
通讯作者	Devkota, HP (corresponding author), Kumamoto Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 5-1 Oe honmachi, Kumamoto 8620973, Japan.
来源期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
EISSN	1872-7573
出版年	2021
卷号	267
英文摘要	Ethnopharmacological relevance: Guiera senegalensis J.F. Gmel. (Combretaceae), commonly known as Gubeish in Sudan, is a small shrub abundant in semi-desert areas of the Sudano-Sahelian zone. It is widely used in African traditional medicine as a tonic and for the treatment of many complications such as respiratory and gastrointestinal disorders, microbial and parasitic infections. Aim of the review: The aim of this review is to critically analyze the reports on the traditional uses, ethnopharmacological studies, chemical constituents and pharmacological activities of G. senegalensis. Methods: Scientific information on G. senegalensis was retrieved from the online bibliographic databases (e.g. like MEDLINE/PubMed, SciFinder, Web of Science, Google Scholar, Scopus, Elsevier, SpringerLink). Other scientific information was acquired from secondary resources including books and proceedings, library catalogs, and dissertations. Results: G. senegalensis is reported to be widely used traditionally for the treatment of various diseases in many African countries. Most of these studies are reported from Burkina Faso, Guinea, Mali, Nigeria, Senegal, and Sudan. Phytochemical studies have revealed the presence of a total of 46 compounds belonging to major phytochemical classes namely; phenolic compounds, alkaloids, and triterpenes. Among them, galloylquinic acid derivatives and flavonoids are the most frequently reported constituents. The extracts and compounds have shown diverse biological activities including antimicrobial, anti-inflammatory, antiprotozoal activities and activities against gastrointestinal and respiratory disorders. Conclusion: G. senegalensis is widely used in most African traditional medicine systems and used among African people for the treatment of many diseases. Although there are many reports on its biological activities, most of these studies are based on in vitro systems and only very few are based on in vivo systems. Also, some of these pharmacological data are insufficient and lack essential parameters such as proper positive and negative controls, and calculating the minimum inhibitory concentration (MIC) values. From these studies, it is difficult to assess the future clinical potential of this plant without detailed studies in animal models or in humans. Similarly, there are not many reports on the action mechanism of the extracts and compounds. Future studies should focus to explore the therapeutic potential of G. senegalensis with advance experimental protocols and cutting-edge technologies.
英文关键词	Guiera senegalensis Combretaceae Gubeish Ethnopharmacological Bioactive compounds
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000606373500006
WOS关键词	VITRO ANTIMALARIAL ACTIVITY ; J. F GMEL ; MEDICINAL-PLANTS ; IN-VITRO ; ETHNOBOTANICAL SURVEY ; TRADITIONAL MEDICINE ; CARBON STOCKS ; ANTIBACTERIAL ACTIVITY ; BIOLOGICAL-ACTIVITIES ; LEAVES EXTRACT
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348007
作者单位	[Dirar, Amina Ibrahim; Devkota, Hari Prasad] Kumamoto Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 5-1 Oe honmachi, Kumamoto 8620973, Japan; [Dirar, Amina Ibrahim] Natl Res Ctr, Med Aromat Plants & Tradit Med Res Inst MAPTRI, POB 2404,Mek Nimr St, Khartoum, Sudan; [Dirar, Amina Ibrahim] Natl Univ Sudan, Fac Clin & Ind Pharm, POB 3783, Khartoum, Sudan; [Devkota, Hari Prasad] Hlth life Sci Interdisciplinary & Glocal Oriented, Program Leading Grad Sch, Chuo Ku, 5-1 Oe honmachi, Kumamoto 8620973, Japan
推荐引用方式 GB/T 7714	Dirar, Amina Ibrahim,Devkota, Hari Prasad. Ethnopharmacological uses, phytochemistry and pharmacological activities of Guiera senegalensis JF Gmel. (Combretaceae)[J],2021,267.
APA	Dirar, Amina Ibrahim,&Devkota, Hari Prasad.(2021).Ethnopharmacological uses, phytochemistry and pharmacological activities of Guiera senegalensis JF Gmel. (Combretaceae).JOURNAL OF ETHNOPHARMACOLOGY,267.
MLA	Dirar, Amina Ibrahim,et al."Ethnopharmacological uses, phytochemistry and pharmacological activities of Guiera senegalensis JF Gmel. (Combretaceae)".JOURNAL OF ETHNOPHARMACOLOGY 267(2021).