干旱区生态环境知识资源中心(Arid): Antigenotoxic, antiproliferative and antimetastatic properties of a combination of native medicinal plants from Argentina

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DOI	10.1016/j.jep.2020.113479
	Antigenotoxic, antiproliferative and antimetastatic properties of a combination of native medicinal plants from Argentina
	Carabajal, Monica Patricia Antonella; Piloto-Ferrer, Janet; Nicollela, Heloiza Diniz; Squarisi, Iara Silva; Guissone, Ana Paula Prado; Esperandim, Tabata Rodrigues; Tavares, Denise Crispim; Isla, Maria Ines; Zampini, Iris Catiana
通讯作者	Isla, MI ; Zampini, IC (corresponding author), Univ Nacl Tucuman, Fac Ciencias Nat, CONICET, UNT,Inst Bioprospecc & Fisiol Vegetal INBIOFIV, San Lorenzo 1469, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
来源期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
EISSN	1872-7573
出版年	2021
卷号	267
英文摘要	Ethnopharmacological relevance: Jarilla is the common name of an appreciated group of native plants from the semi-arid region in Argentina (Larrea cuneifolia Cav., Larrea divaricata Cav. and Zuccagnia punctata Cav.) that have been historically consumed to heal respiratory, musculoskeletal and skin ailments, as well as recommended for weakness/tiredness, hypertension, diabetes and cancer treatment. It was previously reported that some biological properties could be improved when these plants are used jointly. Infusions of a defined mixture, composed by three Jarilla species, L. cuneifolia: L. divaricata: Z. punctata (0.5:0.25:0.25) (HM2) showed synergistic and additive effect on antioxidant activity even after passing through the gastro-duodenal tract. Aim of the study: The main purpose of this work was to evaluate antigenotoxic, antitumor, and anti-metastatic properties of the Jarilla species that grow in the Northwest of Argentina and a herbal combination of them. Material and methods: Infusions of Jarilla mixture (HM2), and of each single plant species were prepared. Phenolic profiles of infusions were analyzed by HPLC-ESI-MS/MS and two relevant chemical markers were quantified. The antigenotoxic activity was evaluated by using the Ames test and the Cytokinesis-Block Micronucleus (CBMN) assay against direct mutagens. Evaluations of both cytotoxicity and antiproliferative effects were conducted on tumor and non-tumor cell lines. Both in vivo tumoral growth and metastasis inhibition were evaluated by using a carcinoma model on Balb/c mice. Results: HM2 mix could suppress genetic and chromosome mutations induced by 4-nitro-o-phenylendiamine (4NPD) and doxorubicin. Herbal mixture and single plant infusions showed cytotoxic effect against mammary, uterus, and brain tumoral cells without a selective action vs normal human cell line. HM2 mix was able to reduce mammary tumor mass on the Balb/c mice model and showed a significant reduction in the number of metastatic nodules in the lungs. Conclusions: Our results suggest that the combinations of three Jarilla species from northwest Argentina would be a promising alternative to treat or slow down the development of chronic diseases, such as cancer.
英文关键词	Larrea cuneifolia Larrea divaricata Zuccagnia punctata Micronuclei Clonogenic Antimutagenic Antitumoral Antimetastatic effect
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000606371200007
WOS关键词	NORDIHYDROGUAIARETIC ACID NDGA ; ZUCCAGNIA-PUNCTATA ; IN-VITRO ; LARREA-DIVARICATA ; FLAVONOIDS ; EXTRACTS ; CANCER ; MUTAGENICITY ; CHALCONES ; CYTOTOXICITY
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/348006
作者单位	[Carabajal, Monica Patricia Antonella; Isla, Maria Ines; Zampini, Iris Catiana] Univ Nacl Tucuman, Fac Ciencias Nat, CONICET, UNT,Inst Bioprospecc & Fisiol Vegetal INBIOFIV, San Lorenzo 1469, RA-4000 San Miguel De Tucuman, Tucuman, Argentina; [Carabajal, Monica Patricia Antonella; Isla, Maria Ines; Zampini, Iris Catiana] Univ Nacl Tucuman, Inst Miguel Lillo, San Lorenzo 1469, RA-4000 San Miguel De Tucuman, Tucuman, Argentina; [Piloto-Ferrer, Janet] Ctr Invest & Desarrollo Medicamentos CIDEM, Dept Toxicol Genet & Antitumorales, Ave 26,1605 E Puentes Grandes & Boyeros, Havana, Cuba; [Nicollela, Heloiza Diniz; Squarisi, Iara Silva; Guissone, Ana Paula Prado; Esperandim, Tabata Rodrigues; Tavares, Denise Crispim] Univ Franca, Ave Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP, Brazil
推荐引用方式 GB/T 7714	Carabajal, Monica Patricia Antonella,Piloto-Ferrer, Janet,Nicollela, Heloiza Diniz,et al. Antigenotoxic, antiproliferative and antimetastatic properties of a combination of native medicinal plants from Argentina[J],2021,267.
APA	Carabajal, Monica Patricia Antonella.,Piloto-Ferrer, Janet.,Nicollela, Heloiza Diniz.,Squarisi, Iara Silva.,Guissone, Ana Paula Prado.,...&Zampini, Iris Catiana.(2021).Antigenotoxic, antiproliferative and antimetastatic properties of a combination of native medicinal plants from Argentina.JOURNAL OF ETHNOPHARMACOLOGY,267.
MLA	Carabajal, Monica Patricia Antonella,et al."Antigenotoxic, antiproliferative and antimetastatic properties of a combination of native medicinal plants from Argentina".JOURNAL OF ETHNOPHARMACOLOGY 267(2021).