干旱区生态环境知识资源中心(Arid): Acute-phase protein alpha-1-acid glycoprotein is negatively associated with feed intake in postpartum dairy cows

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DOI	10.3168/jds.2020-19025
	Acute-phase protein alpha-1-acid glycoprotein is negatively associated with feed intake in postpartum dairy cows
	Brown, W. E.; Garcia, M.; Mamedova, L. K.; Christman, K. R.; Zenobi, M. G.; Staples, C. R.; Leno, B. M.; Overton, T. R.; Whitlock, B. K.; Daniel, J. A.; Bradford, B. J.
通讯作者	Bradford, BJ (corresponding author), Kansas State Univ, Dept Anim Sci & Ind, Manhattan, KS 66502 USA. ; Bradford, BJ (corresponding author), Michigan State Univ, Dept Anim Sci, E Lansing, MI 48824 USA.
来源期刊	JOURNAL OF DAIRY SCIENCE
ISSN	0022-0302
EISSN	1525-3198
出版年	2021
卷号	104 期号:1 页码:806-817
英文摘要	alpha-1-Acid glycoprotein (AGP) is an acute-phase protein that may suppress dry matter intake (DMI), potentially by acting on the leptin receptor in the hypothalamus. Our objectives were to characterize plasma AGP concentration and associations with DMI during the transition period, and to determine the utility of AGP to identify or predict cows with low DMI. Plasma samples (n = 2,086) from 434 Holstein cows in 6 studies were analyzed on d -21, -13 +/- 2, -3, 1, 3, 7 +/- 1, 14 +/- 1, and 21 +/- 1 relative to parturition. A commercially available ELISA kit specific for bovine AGP was validated, and 2 internal controls were analyzed on each plate with interplate variation of 15.0 and 17.3%, respectively. Bivariate analysis was used to assess the relationship between AGP and DMI. For significant associations, treatment(study) was added to the model, and quadratic associations were included in the model if significant. Plasma AGP concentration (+/- SEM) increased from 213 +/- 37.3 mu g/mL on d -3 to 445 +/- 60.0 mu g/mL on d 14. On d 3, AGP was associated negatively with DMI in a quadratic manner for wk 1 and wk 2 and linearly for wk 3. Day 7 AGP was associated negatively with MIT in a quadratic manner for wk 2 and linearly for wk 3. Similarly, d 14 AGP was negatively associated with DMI for wk 3 and wk 4. As d 3 AGP concentration increased over the interquartile range, a calculated 1.4 (8.5%), 0.5 (2.7%), and 0.4 (1.9%) kg/d reduction in predicted DMI was detected during wk 1, 2, and 3, respectively. Using bivariate analysis, d 3 AGP explained 10% of the variation in DMI during wk 1. We explored the clinical utility of d 3 AGP to diagnose low DMI, defined as wk 1 DMI >1 standard deviation below the mean. Receiver operating characteristic analysis identified a threshold of 480.9 mu g/mL, providing 76% specificity and 48% sensitivity (area under the curve = 0.60). Limited associations occurred between AGP and blood biornarkers; however, ACP was associated with plasma haptoglobin concentration postpartum and incidence of displaced abomasum, retained placenta, and metritis. These results demonstrate a negative association between plasma ACP concentration arid DMI in early-postpartum dairy cows, although its diagnostic performance was marginal. Further investigation into whether AGP directly suppresses DMI in dairy cattle is warranted.
英文关键词	biomarker appetite periparturient cow
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000600557600064
WOS关键词	IMMUNE-SYSTEM ACTIVATION ; SERUM AMYLOID-A ; ALPHA(1)-ACID GLYCOPROTEIN ; REPRODUCTIVE-PERFORMANCE ; METABOLIC-CHANGES ; MILK-PRODUCTION ; EARLY LACTATION ; ENERGY-BALANCE ; GROWTH-HORMONE ; LYSINE NEEDS
WOS类目	Agriculture, Dairy & Animal Science ; Food Science & Technology
WOS研究方向	Agriculture ; Food Science & Technology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/347996
作者单位	[Brown, W. E.; Garcia, M.; Mamedova, L. K.; Christman, K. R.; Bradford, B. J.] Kansas State Univ, Dept Anim Sci & Ind, Manhattan, KS 66502 USA; [Mamedova, L. K.; Bradford, B. J.] Michigan State Univ, Dept Anim Sci, E Lansing, MI 48824 USA; [Zenobi, M. G.; Staples, C. R.] Univ Florida, Dept Anim Sci, Gainesville, FL 32608 USA; [Leno, B. M.; Overton, T. R.] Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA; [Whitlock, B. K.] Univ Tennessee, Coll Vet Med, Knoxville, TN 27996 USA; [Daniel, J. A.] Berry Coll, Dept Anim Sci, Mt Berry, GA 30149 USA
推荐引用方式 GB/T 7714	Brown, W. E.,Garcia, M.,Mamedova, L. K.,et al. Acute-phase protein alpha-1-acid glycoprotein is negatively associated with feed intake in postpartum dairy cows[J],2021,104(1):806-817.
APA	Brown, W. E..,Garcia, M..,Mamedova, L. K..,Christman, K. R..,Zenobi, M. G..,...&Bradford, B. J..(2021).Acute-phase protein alpha-1-acid glycoprotein is negatively associated with feed intake in postpartum dairy cows.JOURNAL OF DAIRY SCIENCE,104(1),806-817.
MLA	Brown, W. E.,et al."Acute-phase protein alpha-1-acid glycoprotein is negatively associated with feed intake in postpartum dairy cows".JOURNAL OF DAIRY SCIENCE 104.1(2021):806-817.